Article
Plant Sciences
Rui-Ting Sun, Xiang-Cao Feng, Ze-Zhi Zhang, Nong Zhou, Hai-Dong Feng, Yi-Mei Liu, Abeer Hashem, Al-Bandari Fahad Al-Arjani, Elsayed Fathi Abd-Allah, Qiang-Sheng Wu
Summary: This study investigated the effects of Funneliformis mosseae (Fm) and Piriformospora indica (Pi) on the growth, root morphology, sugar concentrations, and secondary metabolite concentrations of Polygonum cuspidatum. The results showed that Fm and Pi promoted plant growth and increased the production of certain secondary metabolites. The combination of Fm and Pi had a better effect on secondary metabolite production compared to single inoculation.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Ru-Jie Shi, Ming-Yan Ye, Yue Liu, Qiang-Sheng Wu, Elsayed Fathi Abd Allah, Nong Zhou
Summary: The study aimed to analyze the effects of exogenous 100 mM melatonin on biomass production, water potential, gas exchange, antioxidant enzyme activities, active components levels, and resveratrol synthase gene expression of Polygonum cuspidatum seedlings under well-watered and drought stress conditions. The results showed that the application of exogenous melatonin significantly increased plant growth, leaf gas exchange, antioxidant enzyme activities, and active components levels, providing a reference for drought-resistant cultivation of P. cuspidatum.
Article
Agricultural Engineering
Jian-Dong Wang, Li-Na Fu, Li-Tao Wang, Zi-Hui Cai, Yan-Qiu Wang, Qing Yang, Yu-Jie Fu
Summary: Resveratrol was extracted from Polygonum cuspidatum using NADES, achieving high yield and content of resveratrol with excellent antioxidant activity. Optimization of experimental conditions using RSM and BBD indicated this method can be used as an environmentally friendly and pollution-free approach for extracting and recovering resveratrol from plants.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Agronomy
Ci Deng, Rui-Ting Sun, Qiang Ma, Qing-He Yang, Nong Zhou, Abeer Hashem, Al-Bandari Fahad Al-Arjani, Elsayed Fathi Abd-Allah, Qiang-Sheng Wu
Summary: This study demonstrates that an adequate P fertilizer and arbuscular mycorrhizal fungi (AMF) can promote the production of active medicinal components in Polygonum cuspidatum, with the involvement of associated gene expressions.
Article
Chemistry, Applied
Bo Sun, Yun-Long Zheng, Sheng-Kuan Yang, Jia-Ru Zhang, Xin-Yue Cheng, Reza Ghiladi, Zhuo Ma, Jun Wang, Wen-Wen Deng
Summary: A novel one-pot method based on deep eutectic solvent (DES) was developed to efficiently extract and convert polydatin to resveratrol from Polygonum cuspidatum. The extraction yield of resveratrol using DES was significantly higher than traditional solvents. The DES disrupted plant cell walls to enhance resveratrol yield.
Article
Pharmacology & Pharmacy
Jing-Xin Li, Yu Wang, Ying Hao, Xiao-Kui Huo, Cheng-Peng Sun, Xiao-Xia Zhao, Jin-Cheng Wang, Jian-Bin Zhang, Jing Ning, Xiang-Ge Tian, Chao Wang, Wen-Yu Zhao, Xia Lv, Ya-Chen Li, Xiao-Chi Ma
Summary: In this study, we evaluated the inhibitory effect of Polygonum cuspidatum and its major constituents against Escherichia coli GUS and characterized the inhibitory mechanism of each component. Trans-resveratrol 4'-O-beta-D-glucopyranoside and (-)-epicatechin gallate were identified as the key components and potent inhibitors. Our findings demonstrate the inhibitory effect of Polygonum cuspidatum and its two active components on Escherichia coli GUS, supporting their potential as novel candidates for alleviating drug-induced damage in the mammalian gut.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Fletes-Vargas, Rogelio Rodriguez-Rodriguez, Neith Pacheco, Alejandro Perez-Larios, Hugo Espinosa-Andrews
Summary: This study optimized the extraction conditions of Polygonum cuspidatum root to increase its antioxidant capacity, extraction yield, resveratrol concentration, and total polyphenolic compounds. The optimized extract showed higher biological activities compared to the infusion and could be used for developing functional beverages, antioxidants for edible oils, functional foods, and cosmetics.
Article
Plant Sciences
Badr Alzahrani, Abozer Y. Y. Elderdery, Nasser A. N. Alzerwi, Abdullah Alsrhani, Afnan Alsultan, Musaed Rayzah, Bandar Idrees, Fares Rayzah, Yaser Baksh, Ahmed M. M. Alzahrani, Suresh K. K. Subbiah, Pooi Ling Mok
Summary: Nanotechnology is a popular research topic with revolutionary applications. Tin oxide (SnO2) has gained considerable attention due to its intriguing features. This study successfully tailored the properties of synthesized SnO2 nanoparticles and provided insights into their synthesis process. Additionally, green Pluronic-coated SnO2 nanoparticles showed significant anticancer effects against HepG2 cells.
Article
Biochemistry & Molecular Biology
Wenling Fan, Jiali Wu, Meiqi Gao, Xiaotong Zhang, Wenjing Zhu
Summary: The aim of this study was to improve the solubility, bioavailability, and stability of resveratrol (RES-SD) Solid Dispersion in Polygonum cuspidatum extract (PCE) by hot melt extrusion (HME). The optimum formula was selected by single factor design and orthogonal test, and it was found that PCE-SD increased the dissolution of RES and its oral bioavailability. The auxiliary substances in Polygonum cuspidatum extract had an influence on its preparation technology, stability, and bioavailability.
Article
Agricultural Engineering
Lanlan Zheng, Chao Zhou, Tonghui Li, Zhu Yuan, Hanlin Zhou, Yosuke Tamada, Yongheng Zhao, Jing Wang, Qian Zheng, Xincai Hao, Ping Huang, Xiangyin Luo, Xiao Xiao, Lei You, Qinhua Chen, Zhubing Hu, Xuanbin Wang, Kun Meng, Guodong Wang, Yonghong Zhang, Chen Li
Summary: The study conducted a comprehensive transcriptome analysis of Polygonum cuspidatum, revealing organ-specific gene expression patterns and metabolic pathways of bioactive compounds; flowers exhibited the highest abundance of unique transcripts, while roots stored preferential amounts of resveratrol and emodin.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemical Research Methods
Mei Dai, Daopeng Yuan, Yangmei Lei, Jiangtao Li, Yangjie Ren, Yitong Zhang, Huaixing Cang, Wei Gao, Yixiong Tang
Summary: This study analyzed the molecular structure and enzyme activity of resveratrol synthase, revealing its important role in resveratrol synthesis.
PROTEIN EXPRESSION AND PURIFICATION
(2022)
Article
Biochemistry & Molecular Biology
Huan Xu, Jing Li, Shidong Song, Zhen Xiao, Xuanqing Chen, Boxuan Huang, Mengsi Sun, Guoqing Su, Demin Zhou, Guanyu Wang, Ran Hao, Na Wang
Summary: During the pandemic, traditional Chinese medicine P. cuspidatum is considered as a potential broad-spectrum inhibitor for the treatment of coronavirus infections, with the ability to suppress virus replication and serve as specific and selective inhibitors for SARS-CoV-2 and viral cysteine proteases like 3CLpro and PLpro.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Pharmacology & Pharmacy
Huarong Xu, Jiameng Qu, Jian Wang, Kefei Han, Qing Li, Wenchuan Bi, Ran Liu
Summary: This study developed a new method using high resolution mass spectrometry and in silico strategy to search for potential chemical ingredients in Polygonum cuspidatum (PC) that target the TGF-I3 RI. Resveratrol, a compound found in PC, was identified to have excellent biological activity on TGF-I3 RI and potential as a treatment for PF.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Biochemical Research Methods
Xuemei Xue, Fei Deng, Zhenkai Ge, Jingwen Meng, Xiya Liu, Yongheng Zhao, Yanggen Hu, Xu Ling
Summary: The study aimed to develop an effective sample pretreatment method for measuring the concentrations of resveratrol and polydatin in plant tissues, showing good linearity and low detection limits. The adopted method demonstrated high extraction efficiency and sensitivity for the analysis of traditional Chinese medicine samples.
PHYTOCHEMICAL ANALYSIS
(2022)
Article
Environmental Sciences
Marcus Vinicius Oliveira Barros de Alencar, Muhammad Torequl Islam, Ana Maria Oliveira Ferreira da Mata, Antonielly Campinho dos Reis, Rosalia Maria Torres de Lima, Jose Roberto de Oliveira Ferreira, Joao Marcelo de Castro e Sousa, Paulo Michel Pinheiro Ferreira, Ana Amelia de Carvalho Melo-Cavalcante, Abdur Rauf, Hassan A. Hemeg, Khalaf F. Alsharif, Haroon Khan
Summary: This study evaluates the anticancer effects of Phytol on sarcoma 180 and human leukemia cell lines. The results show that Phytol significantly reduces cell viability and division rate, induces DNA damage and apoptosis, and exhibits potential anticancer effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Oncology
Wei Guo, Yun-Fan Sun, Min-Na Shen, Xiao-Lu Ma, Jiong Wu, Chun-Yan Zhang, Yan Zhou, Yang Xu, Bo Hu, Min Zhang, Gang Wang, Wei-Qin Chen, Lin Guo, Ren-Quan Lu, Chao-Hui Zhou, Xin Zhang, Ying-Hong Shi, Shuang-Jian Qiu, Bai-shen Pan, Ya Cao, Jian Zhou, Xin-Rong Yang, Jia Fan
CLINICAL CANCER RESEARCH
(2018)
Review
Biochemistry & Molecular Biology
Hor-Yue Tan, Ning Wang, Wing Lam, Wei Guo, Yibin Feng, Yung-Chi Cheng
Article
Biochemistry & Molecular Biology
Yaqi Shen, Zhuqing Shen, Lingyan Guo, Qiuyan Zhang, Zhijun Wang, Lei Miao, Minjun Wang, Jian Wu, Wei Guo, Yizhun Zhu
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2018)
Article
Oncology
Xiao-Lu Ma, Jing Zhu, Jiong Wu, Lu Tian, Yao-Yi Gao, Chun-Yan Zhang, Yan Zhou, Qian Dai, Bei-Li Wang, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo
Article
Chemistry, Medicinal
Mimi Li, Xia Li, Zhonglian Cao, Yuntong Wu, Ji-An Chen, Jie Gao, Zhijun Wang, Wei Guo, Xianfeng Gu
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Editorial Material
Oncology
Xin-Rong Yang, Wei Guo
ANNALS OF SURGICAL ONCOLOGY
(2019)
Review
Oncology
Feiyu Chen, Ning Wang, Hor-Yue Tan, Wei Guo, Cheng Zhang, Yibin Feng
CANCER BIOLOGY & THERAPY
(2019)
Article
Oncology
Beili Wang, Feng Li, Luya Cheng, Yanxia Zhan, Boting Wu, Pu Chen, Junfei Shen, Wenhao Wu, Xiaolu Ma, Jie Zhu, Baishen Pan, Wei Guo, Yunfeng Cheng
Article
Oncology
Xiao-Lu Ma, Min-Na Shen, Bo Hu, Bei-Li Wang, Wen-Jing Yang, Li-Hua Lv, Hao Wang, Yan Zhou, An-Li Jin, Yun-Fan Sun, Chuan-Yan Zhang, Shuang-Jian Qiu, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2019)
Article
Medicine, Research & Experimental
Lin Sun, Chunyan Zhang, Yinghui Ju, Bin Tang, Meixiu Gu, Baishen Pan, Wei Guo, Beili Wang
MEDICAL SCIENCE MONITOR
(2019)
Article
Cell Biology
Lingling Chang, Zhijun Wang, Fenfen Ma, Bahieu Tran, Rui Zhong, Ying Xiong, Tao Dai, Jian Wu, Xiaoming Xin, Wei Guo, Ying Xie, Yicheng Mao, Yi-Zhun Zhu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Medical Laboratory Technology
Beili Wang, Jie Zhu, Xiaolu Ma, Hao Wang, Shuangjian Qiu, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo, Yunfeng Cheng
CLINICA CHIMICA ACTA
(2019)
Article
Cell Biology
Qiu-Yan Zhang, Zhi-Jun Wang, Lei Miao, Ying Wang, Ling-Ling Chang, Wei Guo, Yi-Zhun Zhu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Cardiac & Cardiovascular Systems
Guo Wei, Wang Zhijun, Jue Hao, Dong Chunnan, Yang Cheng
CARDIOVASCULAR THERAPEUTICS
(2020)
Editorial Material
Cell Biology
Hongming Pan, Yuting Jian, Feijie Wang, Shaokun Yu, Jiannan Guo, Juntao Kan, Wei Guo
Summary: This article discusses the crucial role of the NLRP3 inflammasome in maintaining gut microbiota homeostasis, gut health, and immune system stability.