Article
Biochemistry & Molecular Biology
Paweena Dana, Ryusho Kariya, Worachart Lert-itthiporn, Wunchana Seubwai, Saowaluk Saisomboon, Chaisiri Wongkham, Seiji Okada, Sopit Wongkham, Kulthida Vaeteewoottacharn
Summary: This study focused on the role of CD147 in promoting proinflammatory cytokine production in cholangiocarcinoma (CCA), revealing that CD147-regulated cytokines, such as IL-6, IL-8, and GM-CSF, play a critical role in CCA invasion. The findings suggest that modulation of CD147-related inflammation could be a promising therapeutic strategy for advanced CCA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Tomonori Masuda, Akihisa Fukuda, Go Yamakawa, Mayuki Omatsu, Mio Namikawa, Makoto Sono, Yuichi Fukunaga, Munemasa Nagao, Osamu Araki, Takaaki Yoshikawa, Satoshi Ogawa, Kenji Masuo, Norihiro Goto, Yukiko Hiramatsu, Yu Muta, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Toshihiko Masui, Etsuro Hatano, Tomoko Matsuzaki, Makoto Noda, Hiroshi Seno
Summary: RECK downregulation promotes the development and metastasis of pancreatic ductal adenocarcinoma (PDAC) by inducing epithelial-mesenchymal transition (EMT) and inflammatory cancer-associated fibroblast-like cells. Reexpression of RECK reduces metastasis and changes the tumor phenotype from mesenchymal to epithelial, suggesting that RECK could be an important therapeutic target for human PDAC.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Yumi Kwon, Seong-Jun Park, Binh Thanh Nguyen, Mi Jeong Kim, Sejin Oh, Hwanho Lee, Narae Park, Hyun Seok Kim, Min-Jung Kang, Byung Soh Min, Jin-Won Lee, Eun Gyeong Yang, Cheolju Lee
Summary: The research analyzed plasma proteome of CRC patients, cancer secretome upon MMP-2 knockdown, and publicly available CRC tissue proteome data to unveil the perturbed proteomic signal during MMP-2 induced cancer progression. The integrative analysis revealed that EMT-associated proteins were regulated by MMP-2 perturbation and exhibited significantly increased expressions as disease progressed from TNM stage I to II. The study also identified a possible association between MMP-2 up-regulation and activation of focal adhesion kinase signaling in CRC patient tissues.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Reihaneh Alsadat Mahmoudian, Maryam Lotfi Gharaie, Mohammad Reza Abbaszadegan, Ali Alasti, Mohammad Mahdi Forghanifard, Atena Mansouri, Mehran Gholamin
Summary: This study investigated the expression of MMP-13, TWIST1, and CD44 in ESCC and found significant correlations with clinical features, such as tumor progression and invasion. The results suggest that the TWIST1-CD44-MMP-13 axis may be involved in tumor aggressiveness and could serve as diagnostic markers and therapeutic targets in ESCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Fateme Eidizade, Mohammad Soukhtanloo, Rahele Zhiani, Jamshid Mehrzad, Farshad Mirzavi
Summary: This research investigates the effects of urolithin-B on glioblastoma multiforme (GBM) U87 cells. The results suggest that urolithin-B can decrease cell viability, induce necrosis and cell cycle arrest, increase reactive oxygen species production, and reduce cell migration in U87 cells. These findings indicate that urolithin-B may be a promising compound for GBM treatment.
Article
Oncology
Han-Soo Kim, Ha Jeong Kim, Mi Ra Lee, Ilkyu Han
Summary: The study found that the expression level of EMMPRIN in osteosarcoma is associated with metastasis-free survival, and EMMPRIN plays an important role in osteosarcoma metastasis by regulating the production of MMP and VEGF.
Article
Biochemistry & Molecular Biology
Katarzyna Ratajczak-Wielgomas, Alicja Kmiecik, Piotr Dziegiel
Summary: The expression of POSTN is significantly increased in NSCLC and may serve as an independent prognostic factor. POSTN knockdown inhibits the migration and invasion of lung cancer cells, potentially through modulating the expression of MMP-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medical Laboratory Technology
Xiaoqing Xu, Xiaomin Lu, Liping Chen, Ke Peng, Fuhai Ji
Summary: Matrix metalloproteinase-1 (MMP1) plays a role in perineural invasion (PNI) of pancreatic cancer (PC). This study found that MMP1 is highly expressed in PC tissues and is positively associated with PNI. Silencing MMP1 inhibits the migration and invasion of PC cells and prevents EMT and Schwann-like cell differentiation by blocking the activation of the NT-3/TrkC signaling pathway, thereby alleviating PNI.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Ya-Tang Chiang, Yu-Bai Xiao, Shan-hui Hsu, Shu-Wei Chang, Chia-Ching Chou
Summary: Tannic acid (TA) has antibacterial, antioxidant, and anti-inflammatory properties and acts as an adhesive, hemostatic, and crosslinking agent in hydrogels. TA has been reported to inhibit MMP-2/- 9 activities, thereby improving tissue remodeling and wound healing. In this study, atomistic modeling was used to explore the mechanisms and structures of TA binding with MMP-2 and MMP-9, revealing the specific binding regions and molecular interactions involved. Understanding the binding mechanism and dynamics of TA with these MMPs provides crucial knowledge on the effects of TA on MMPs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Oncology
Shuo Cai, Zhiwei Sun, Ping-Hui Sun, Xiangyu Gao, Ke Ji, Xiuyun Tian, Jiafu Ji, Chunyi Hao, Faris Soliman, Chang Liu, Bilal Al-Sarireh, Paul Griffiths, Stephen Hiscox, Wen G. Jiang, Lin Ye
Summary: The study revealed that reduced expression of Kidins220 was associated with tumorigenesis, metastasis, and overall survival in pancreatic cancer. Knockdown of Kidins220 promoted proliferation, colony formation, and tumorigenic capacity of pancreatic cancer cells, and regulated cell migration through the EGFR/AKT/ERK signaling pathway. Kidins220 also influenced cell invasion via MMP1 in pancreatic cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiao Wu, Liang Chen, Chuan Qin, Fei Huo, Xue Liang, Xu Yang, Kui Zhang, Peng Lin, Jiangning Liu, Zhuan Feng, Jiansheng Zhou, Zhuo Pei, Yatao Wang, Xiu-Xuan Sun, Ke Wang, Jiejie Geng, Zhaohui Zheng, Xianghui Fu, Man Liu, Qingyi Wang, Zheng Zhang, Huijie Bian, Ping Zhu, Zhi-Nan Chen
Summary: This study systematically analyzed lung pathogenesis in SARS-CoV-2-infected humanized CD147 transgenic mice and identified CD147 as a crucial regulator for fibroblast activation induced by SARS-CoV-2. The study demonstrated that CD147 plays a significant role in SARS-CoV-2-triggered progressive pulmonary fibrosis and identified it as a potential therapeutic target for treating post-COVID-19 pulmonary fibrosis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Cell Biology
Liangjun Jiang, Kunkun Sheng, Cong Wang, Deting Xue, Zhijun Pan
Summary: Recent studies have shown that MMP2-I1 plays a positive role in the osteogenesis of human bone marrow mesenchymal stem cells and angiogenesis of human vascular endothelial cells. It activates signaling pathways to promote osteogenesis and angiogenesis, and has been found to enhance bone formation and prevent bone loss in animal models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Medicinal
Sanjib Das, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Xin-sheng Deng, Xianzhong Meng, David Fullerton, Matthew Stone, James Jaggers
Summary: This study demonstrates that complement induces profibrogenic activities in aortic valve interstitial cells through the activation of ERK1/2-mediated Runx-2 signaling pathways, suggesting a potential therapeutic target to limit the progression of calcific aortic valve disease.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, Research & Experimental
Iolanda Scognamiglio, Lorenza Cocca, Ilaria Puoti, Francesco Palma, Francesco Ingenito, Cristina Quintavalle, Alessandra Affinito, Giuseppina Roscigno, Silvia Nuzzo, Rosario Vincenzo Chianese, Stefania Belli, Guglielmo Thomas, Timo Schomann, Alan Chan, Maria Patrizia Stoppelli, Gerolama Condorelli
Summary: Research has shown that exosomes derived from triple-negative breast cancer cells can activate normal fibroblasts and transform them into cancer-associated fibroblasts, thereby promoting tumor invasion. These findings highlight the significant role of breast cancer cells in remodeling the tumor microenvironment and contributing to tumor evolution.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)