Development of an efficient yeast platform for cannabigerolic acid biosynthesis

Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast

(2023) Ning Qin et al.   CELL

Catalytic asymmetric synthesis of cannabinoids and menthol from neral

(2023) Joyce A. A. Grimm et al.   NATURE

Programmable protein delivery with a bacterial contractile injection system

(2023) Joseph Kreitz et al.   NATURE

Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

(2022) Richard B. van Breemen et al.   JOURNAL OF NATURAL PRODUCTS

Engineering the amoeba Dictyostelium discoideum for biosynthesis of a cannabinoid precursor and other polyketides

(2022) Christin Reimer et al.   NATURE BIOTECHNOLOGY

SignalP 6.0 predicts all five types of signal peptides using protein language models

(2022) Felix Teufel et al.   NATURE BIOTECHNOLOGY

Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals

(2022) Christopher A. Legare et al.   PHARMACOLOGY

Machine learning modeling of family wide enzyme-substrate specificity screens

(2022) Samuel Goldman et al.   PLoS Computational Biology

Engineering eukaryote-like regulatory circuits to expand artificial control mechanisms for metabolic engineering in Saccharomyces cerevisiae

(2022) Bingyin Peng et al.   Communications Biology

Oxidative stress response pathways in fungi

(2022) Hajar Yaakoub et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure-Guided Engineering of Prenyltransferase NphB for High-Yield and Regioselective Cannabinoid Production

(2022) Kevin Jie Han Lim et al.   ACS Catalysis

A polarized supercell produces specialized metabolites in cannabis trichomes

(2022) Samuel J. Livingston et al.   CURRENT BIOLOGY

A microbial supply chain for production of the anti-cancer drug vinblastine

(2022) Jie Zhang et al.   NATURE

Engineering Pheromone-Mediated Quorum Sensing with Enhanced Response Output Increases Fucosyllactose Production in Saccharomyces cerevisiae

(2022) Mingyuan Xu et al.   ACS Synthetic Biology

Coupling Cell Communication and Optogenetics: Implementation of a Light-Inducible Intercellular System in Yeast

(2022) Vicente Rojas et al.   ACS Synthetic Biology

Auxin-mediated protein depletion for metabolic engineering in terpene-producing yeast

(2021) Zeyu Lu et al.   Nature Communications

Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome

(2021) Claudia Montllor-Albalate et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories

(2021) Quanli Liu et al.   Nature Communications

Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase

(2020) Kashish Singh et al.   CELL

Phytocannabinoids: Origins and Biosynthesis

(2020) Thies Gülck et al.   TRENDS IN PLANT SCIENCE

Bioengineering studies and pathway modeling of the heterologous biosynthesis of tetrahydrocannabinolic acid in yeast

(2020) Fabian Thomas et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Synthetic Biology of Cannabinoids and Cannabinoid Glucosides in Nicotiana benthamiana and Saccharomyces cerevisiae

(2020) Thies Gülck et al.   JOURNAL OF NATURAL PRODUCTS

A bio-inspired cell-free system for cannabinoid production from inexpensive inputs

(2020) Meaghan A. Valliere et al.   Nature Chemical Biology

Complete biosynthesis of cannabinoids and their unnatural analogues in yeast

(2019) Xiaozhou Luo et al.   NATURE

Cannabis glandular trichomes alter morphology and metabolite content during flower maturation

(2019) S. J. Livingston et al.   PLANT JOURNAL

Structure of the Cannabis sativa olivetol‐producing enzyme reveals cyclization plasticity in type III polyketide synthases

(2019) Lewis J. Kearsey et al.   FEBS Journal

Tailoring the Saccharomyces cerevisiae endoplasmic reticulum for functional assembly of terpene synthesis pathway

(2019) Jae-Eung Kim et al.   METABOLIC ENGINEERING

Synthetic Pathway for the Production of Olivetolic Acid in Escherichia coli

(2018) Zaigao Tan et al.   ACS Synthetic Biology

N-terminal SKIK peptide tag markedly improves expression of difficult-to-express proteins in Escherichia coli and Saccharomyces cerevisiae

(2017) Teruyo Ojima-Kato et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Engineering fungal de novo fatty acid synthesis for short chain fatty acid production

(2017) Jan Gajewski et al.   Nature Communications

Rewriting yeast central carbon metabolism for industrial isoprenoid production

(2016) Adam L. Meadows et al.   NATURE

A Cas9-based toolkit to program gene expression inSaccharomyces cerevisiae

(2016) Amanda Reider Apel et al.   NUCLEIC ACIDS RESEARCH

Disrupted short chain specific β-oxidation and improved synthase expression increase synthesis of short chain fatty acids in Saccharomyces cerevisiae

(2015) Christopher Leber et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cannabinoids for Medical Use

(2015) Penny F. Whiting et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution

(2014) Robin van der Lee et al.   Cell Reports

Promoters maintain their relative activity levels under different growth conditions

(2013) L. Keren et al.   Molecular Systems Biology

Peroxisomal Fatty Acid Uptake Mechanism inSaccharomyces cerevisiae

(2012) Carlo W. T. van Roermund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hexanoyl-CoA precursor for cannabinoid biosynthesis is formed by an acyl-activating enzyme in Cannabis sativa trichomes

(2012) Jake M. Stout et al.   PLANT JOURNAL

Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides

(2012) S. J. Gagne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway

(2009) Futoshi Taura et al.   FEBS LETTERS

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response

(2009) Sebastian Schuck et al.   JOURNAL OF CELL BIOLOGY