Article
Immunology
Ruijing Zhang, Keman Xu, Ying Shao, Yu Sun, Jason Saredy, Elizabeth Cutler, Tian Yao, Ming Liu, Lu Liu, Charles Drummer, Yifan Lu, Fatma Saaoud, Dong Ni, Jirong Wang, Yafeng Li, Rongshan Li, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Summary: Through studying the transcriptomic heterogeneity of Treg in different tissues, we found shared genes, signaling pathways, and immune functions, providing novel therapeutic targets for immune system diseases and cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Paola Villanueva, Nigel W. Crawford, Mariana Garcia Croda, Simone Collopy, Bruno Araujo Jardim, Tyane de Almeida Pinto Jardim, Laurens Manning, Michaela Lucas, Helen Marshall, Cristina Prat-Aymerich, Alice Sawka, Ketaki Sharma, Darren Troeman, Ushma Wadia, Adilia Warris, Nicholas Wood, Nicole L. Messina, Nigel Curtis, Laure F. Pittet
Summary: This study investigated the prevalence and influencing factors of scar formation following BCG vaccination, as well as participants' perception of the scars. The results showed that 76% of the recipients developed a scar, with the lowest prevalence in Spain and the highest in the UK. Factors such as absence of post-injection wheal, BCG revaccination, female sex, older age, and study country influenced scar prevalence. The majority of participants did not mind having the scar and did not regret getting vaccinated.
Correction
Multidisciplinary Sciences
Paola Villanueva, Nigel W. Crawford, Mariana Garcia Croda, Simone Collopy, Bruno Araujo Jardim, Tyane de Almeida Pinto Jardim, Laurens Manningi, Michaela Lucas, Helen Marshallo, Cristina Prat-Aymerich, Alice Sawka, Ketaki Sharma, Darren Troeman, Ushma Wadia, Adilia Warris, Nicholas Wood, Nicole L. Messina, Nigel Curtis, Laure F. Pittet
Summary: This study found that the prevalence of scar formation following BCG vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger among children who develop a BCG scar. Individual-related factors, study country, and vaccination-related factors influenced BCG scar prevalence 12 months following BCG vaccination of adults.
Article
Multidisciplinary Sciences
Maria Jesus Rios-Blancas, Hector Lamadrid-Figueroa, Miguel Betancourt-Cravioto, Rafael Lozano
Summary: A study estimated vaccination coverage and factors associated with completing schemes in children under 5 years old between 2000 and 2018 in Mexico, finding that the coverage did not exceed 95% and caregivers not showing the vaccination card increased significantly during this period. The study highlighted the need for innovative strategies to improve vaccination rates in Mexico.
Article
Medicine, General & Internal
Anele Gela, Melissa Murphy, Miguel Rodo, Kate Hadley, Willem A. Hanekom, W. Henry Boom, John L. Johnson, Daniel F. Hoft, Simone A. Joosten, Tom H. M. Ottenhoff, Sara Suliman, D. Branch Moody, David M. Lewinsohn, Mark Hatherill, Chetan Seshadri, Elisa Nemes, Thomas J. Scriba, Libby Briel, Hellen Veldtsman, Nondumiso Khomba, Bernadette Pienaar, Hadn Africa, Marcia Steyn
Summary: DURT cells, which have nearly unrestricted antigen recognition, play an important role in tuberculosis vaccine development. This study investigated the roles of DURT cells in BCG vaccination and found that BCG did not modulate most DURT cell populations.
Article
Chemistry, Analytical
Xin Liu, Baiying Li, Qian Liu, Li Zhang, Rong Zhao, Di Wu, Luojia Wang, Zhongzhong Wang, Guoming Xie, Wenli Feng
Summary: This study constructed various logic gates based on multifunctional dumbbell probes for analyzing multiple cancer-associated miRNAs. The results demonstrated the excellent cell identification capabilities of these logic gates, and their ability to be easily transformed through simple adjustments.
ANALYTICA CHIMICA ACTA
(2023)
Article
Multidisciplinary Sciences
Esther J. M. Taks, Simone J. C. F. M. Moorlag, Konstantin Fohse, Elles Simonetti, Christa E. van der Gaast-de Jongh, Cornelis H. van Werkhoven, Marc J. M. Bonten, Jaap ten Oever, Marien I. de Jonge, Janneke H. H. M. van de Wijgert, Mihai G. Netea
Summary: BCG vaccination before first COVID-19 vaccine did not significantly impact the IgG RBD concentration after COVID-19 vaccination in older European adults.
Article
Immunology
Julia Bitencourt, Marco Polo Peralta-Alvarez, Morven Wilkie, Ashley Jacobs, Daniel Wright, Salem Salman Almujri, Shuailin Li, Stephanie A. Harris, Steven G. Smith, Sean C. Elias, Andrew D. White, Iman Satti, Sally S. Sharpe, Matthew K. O'Shea, Helen McShane, Rachel Tanner
Summary: Tuberculosis is a major health problem worldwide, and the currently-licensed BCG vaccine is not effective enough. Research has shown that the BCG vaccine can induce specific antibodies, which play a crucial role in cellular defense. These findings suggest that the humoral immune response should be further investigated in TB vaccine development.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Mengjin Qu, Xiangmei Zhou, Hao Li
Summary: BCG is the only licensed vaccine against tuberculosis, but its efficacy is variable, calling for the urgent development of a more effective TB vaccine. Strategies like intravenous administration and revaccination have shown promising results, emphasizing the need to revisit BCG vaccination strategies for improving TB prevention.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Daniel Garzon-Chavez, Jackson Rivas-Condo, Adriana Echeverria, Jhoanna Mozo, Emmanuelle Quentin, Jorge Reyes, Enrique Teran
Summary: Research indicates that areas with low BCG vaccine coverage are more likely to have a high prevalence of COVID-19 cases, particularly impacting individuals aged 50-64 years old.
Article
Engineering, Environmental
Zhengyu Yang, Zhen Yang, Lin Ding, Cong Liu, Fujian Zhao, Xiaofeng Chen, Chang Du
Summary: The balance between Treg and Th17 cells is crucial for bone loss in osteoporosis. An immunomodulatory bioactive glass nanoparticle-engineered bone marrow-derived macrophages (BMDMs) can generate extracellular vesicles (SrBGN + M9-EVs), which regulate the Treg/Th17 balance and inhibit bone loss in osteoporosis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Immunology
Nicole L. Messina, Mariana G. Sperotto, Marco A. M. Puga, Patricia V. da Silva, Roberto D. de Oliveira, Cecilia L. Moore, Laure F. Pittet, Tenaya Jamieson, Margareth Dalcolmo, Glauce dos Santos, Bruno Jardim, Marcus V. G. Lacerda, Nigel Curtis, Julio Croda, BRACE Trial Consortium Grp
Summary: This study compared antibody responses to CoronaVac (Sinovac) and ChAdOx1-S (AstraZeneca-Oxford) vaccines in 874 healthcare workers in Brazil. The results showed that ChAdOx1-S induced a stronger anti-spike IgG response than CoronaVac. Recent BCG vaccination did not affect the antibody responses to either vaccine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sayori Kobayashi, Takashi Yoshiyama, Kazuhiro Uchimura, Yuko Hamaguchi, Seiya Kato
Summary: In countries that ceased universal BCG vaccination, an increase in childhood TB notification rate was observed in one out of seven countries, mainly attributed to an increase in pulmonary TB and TB lymphadenitis cases. Challenges in maintaining high vaccine coverage for the target group were common after shifting to selective vaccination. Lessons learned from these countries may help in developing more effective BCG vaccination strategies.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Alexandra L. Morrison, Charlotte Sarfas, Laura Sibley, Jessica Williams, Adam Mabbutt, Mike J. Dennis, Steve Lawrence, Andrew D. White, Mark Bodman-Smith, Sally A. Sharpe
Summary: Intravenously delivered BCG provides superior tuberculosis protection compared with the intradermal route in non-human primates. Gamma delta T cell responses play a crucial role in this protection. IV BCG vaccination expands V delta 2 T cell populations, which are associated with TB protection. Phenotypic and functional changes occur in V delta 2 cells after ID BCG, but do not result in expansion. An aerosol BCG boost induces significant changes in V delta 2 phenotype and function, localizing activated V delta 2 populations to lung mucosal surfaces.
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Analytical
Oswaldo Hernandez-Gonzalez, Sergio Zarazua, Jose Ignacio Veytia-Bucheli, Marco Martin Gonzalez-Chavez, Cristian Jazmin Rodriguez-Pinal, Susanna Edith Medellin-Garibay, Edith Elena Uresti-Rivera, Francisco Javier Perez-Vazquez, Diana Patricia Portales-Perez, Silvia Romano-Moreno, Rosa del Carmen Milan-Segovia
Summary: This study developed and validated an alternative high-performance liquid chromatography method for simultaneous quantification of four antituberculosis drugs in plasma of patients. The method showed linearity, precision, and accuracy, and could be applied for therapeutic drug monitoring and pharmacokinetics studies throughout tuberculosis treatment.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Ana P. Huerta-Garcia, Ana S. Rodriguez-Baez, Susanna E. Medellin-Garibay, Diana P. Portales-Perez, Marco U. Martinez-Martinez, Carlos Abud-Mendoza, David Herrera-Van Oostdam, Silvia Romano-Moreno, Rosa del C. Milan-Segovia
Summary: The study identified the relationship between methotrexate triglutamate concentrations and clinical evolution in rheumatoid arthritis patients, proposing strategies for low-dose methotrexate optimization.
JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Yamelie A. Martinez, Xianwu Guo, Diana P. Portales-Perez, Gildardo Rivera, Julio E. Castaneda-Delgado, Carlos A. Garcia-Perez, Jose A. Enciso-Moreno, Edgar E. Lara-Ramirez
Summary: The study reveals that coronaviruses utilize domain-motif interactions (DMIs) to mimic and hijack host cell biological processes for infection. Shared motifs on viral proteins interacting with human proteins across coronavirus species suggest molecular mimicry as a common strategy for coronavirus infection. Enrichment ontology analysis indicates shared biological process and molecular function terms related to carbon source utilization and potassium channel regulation.
Article
Dermatology
Mitzzy F. Medellin-Luna, Julio E. Castaneda-Delgado, Julio C. Fernandez-Ruiz, Fatima L. Ochoa-Gonzalez, Lorena Troncoso-Vazquez, Salvador Garcia-Cruz, Martin Zapata-Zuniga, Carmen J. Serrano, Diana Portales-Perez, Jose A. Enciso-Moreno, Alberto R. Cervantes-Villagrana
Summary: The study evaluated the effects of MTX on cell proliferation, cell cycle, and wound healing. Results showed that MTX treatment led to reduced cell proliferation, changes in cell cycle, and induction of apoptosis.
JOURNAL OF TISSUE VIABILITY
(2021)
Article
Oncology
Eneida Turijan-Espinoza, Victor Manuel Ruiz-Rodriguez, Edith Elena Uresti-Rivera, Ernesto Martinez-Leija, Jose De Jesus Zermeno-Nava, Arturo Guel-Panola, Silvia Romano-Moreno, Juan Manuel Vargas-Morales, Diana Patricia Portales-Perez
Summary: The study showed a significant association between ABCB1 gene SNP (C3435T) and clinical response to FAC neoadjuvant chemotherapy in breast cancer patients, while polymorphisms in ABCG2 gene were not correlated with chemoresistance.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Obstetrics & Gynecology
Noemi Gaytan-Pacheco, Victoria Lima-Rogel, Alejandro Mendez-Mancilla, Francisco Escalante-Padron, Juan Carlos Toro-Ortiz, Maria Esther Jimenez-Capdeville, Veronica Zaga-Clavellina, Diana P. Portales-Perez, Daniel E. Noyola, Mariana Salgado-Bustamante
Summary: The study demonstrates that maternal overweight and obesity have an impact on the microRNA profile and cytokine expression in newborn infants, suggesting the establishment of epigenetic marks during fetal development.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2021)
Article
Health Care Sciences & Services
Marco Ulises Martinez-Martinez, Deshire Alpizar-Rodriguez, Rogelio Flores-Ramirez, Diana Patricia Portales-Perez, Ruth Elena Soria-Guerra, Francisco Perez-Vazquez, Fidel Martinez-Gutierrez
Summary: A new model was developed to predict the severity of COVID-19 in Mexican patients, with the potential to be useful in epidemiological and medical decision-making. This logistic regression model included 14 main variables, splines, and interactions, with an area under the curve of 82.4% for the validation cohort.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
E. Lares-Villasenor, S. Salazar-Garcia, P. E. Cossio-Torres, C. Aradillas-Garcia, D. P. Portales-Perez, J. M. Vargas-Morales
Summary: This study aimed to evaluate the association of sociodemographic, lifestyle, and cardiometabolic determinants with uric acid (UA) levels in children and adolescents in San Luis Potosi. The results showed that UA was associated with several independent variables, including body mass index (BMI), gender, socioeconomic status, total screen time, exercise, sleep duration, systolic blood pressure, total cholesterol, and high-density lipoprotein cholesterol. Early detection of these determinants can help prevent future diseases and improve the health of this population.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Ana Sofia Herrera-Van Oostdam, Mariana Salgado-Bustamante, Victoria Lima-Rogel, Juan Jose Oropeza-Valdez, Jesus Adrian Lopez, Ivan Daniel Roman Rodriguez, Juan Carlos Toro-Ortiz, David Alejandro Herrera-Van Oostdam, Yamile Lopez-Hernandez, Joel Monarrez-Espino
Summary: This study found distinctive metabolic characteristics in newborns born to GDM mothers, including dysregulation of acylcarnitines, amino acids, and polyamine metabolism. Significant metabolic differences were also observed in the maternal urinary metabolome, indicating the impact of GDM on the neonatal period.
Article
Food Science & Technology
Marco U. Martinez-Martinez, Daniel Vazquez-Maldonado, Stefan Ratering, Cesar Godinez-Hernandez, Rosa Isela Ortiz-Basurto, Ruth E. Soria-Guerra, Bellinda Schneider, Bertha Juarez-Flores, Diana P. Portales-Perez, Sylvia Schnell, Fidel Martinez-Gutierrez
Summary: The consumption of prebiotics has been shown to improve weight status in children with overweight and obesity by promoting gut microbiota diversity and abundance. Synbiotic intervention stimulates beneficial bacteria, leading to a healthier gut microbiota and improved anthropometric indicators.
Article
Social Sciences, Interdisciplinary
Mariana Odemaris Gonzalez-Mares, Celia Aradillas-Garcia, Leonardo Ernesto Marquez-Mireles, Claudia Davinia Monsivais-Nava, Jesus Eduardo Bernal-Medina, Juan Manuel Vargas-Morales, Diana Patricia Portales-Perez, Ana Cristina Cubillas-Tejeda
Summary: The objective of this study was to design, implement and evaluate an educational intervention strategy to prevent and control risk factors for NCD. The study found that the educational intervention was effective in improving knowledge about NCD and promoting healthy habits.
EVALUATION AND PROGRAM PLANNING
(2022)
Article
Biochemistry & Molecular Biology
Oswaldo Hernandez-Gonzalez, Diana Judith Herrera-Vargas, Miguel Ernesto Martinez-Leija, Daniel Zavala-Reyes, Diana Patricia Portales-Perez
Summary: Arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2) play important roles in xenobiotic metabolism and may be involved in carcinogenesis. The enzymatic activity of NATs is crucial in certain types of cancer, but their role in insulin resistance level and the immune system remains to be explored.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Environmental Sciences
Jose Antonio Varela-Silva, Miguel Ernesto Martinez-Leija, Sandra Teresa Orta-Garcia, Ivan Nelinho Perez-Maldonado, Jesus Adrian Lopez, Hiram Hernandez-Lopez, Roberto Gonzalez-Amaro, Emma S. Calderon-Aranda, Diana Patricia Portales-Perez, Mariana Salgado-Bustamante
Summary: Exposure to air pollutants, such as fine particles, carbon monoxide, and PAHs, damages health. PAHs exposure is associated with neoplastic processes, asthma, genotoxicity, altered neurodevelopment, and inflammation. AhR activation is responsible for the induction of proinflammatory cytokines, but the molecular mechanisms remain unknown. This study investigated the expression levels of TNF-alpha, AhR, CYP1B1, miR-125b, and miR-155 in Mexican women exposed to high levels of PAHs. The results showed that high PAHs levels promoted increased AhR expression, suggesting its involvement in various pathogenesis processes.
Article
Nutrition & Dietetics
Carlos Adrian Gonzalez Cortes, Patricia Elizabeth Cossio-Torres, Juan Manuel Vargas-Morales, Marisol Vidal-Batres, Gicela de Jesus Galvan Almazan, Diana Patricia Portales Perez, Aldanely Padron Salas, Celia Aradillas-Garcia
Summary: The study revealed that 8.6% of the pediatric population in Mexico had prediabetes. Boys had higher rates of prediabetes, altered blood pressure, and hyperuricemia compared to girls. Children with prediabetes were at a greater risk of having elevated waist circumference, blood pressure, and uric acid levels.
NUTRICION HOSPITALARIA
(2021)