Article
Pharmacology & Pharmacy
Shengxia Yin, Jian Wang, Lin Chen, Minxin Mao, Rahma Issa, Yu Geng, Rui Huang, Xin Tong, Yong Liu, Chao Wu, Yuxin Chen, Jie Li
Summary: Failure to cure chronic hepatitis B virus (HBV) infection can impair B cell function. This study found that CTLA4 regulates B cell and T follicular helper (Tfh) cell differentiation, and that upregulation of CTLA4 in cTfh cells is associated with decreased HBsAg-specific resting memory B cells. Inhibition of CTLA4 restored HBsAb secretion and promoted plasma cell differentiation. These findings suggest that optimizing Tfh cell responses may lead to a functional cure for chronic HBV infection.
ANTIVIRAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Yong Liu, Xintong Hu, Xiaoli Hu, Lei Yu, Huifan Ji, Wanyu Li, Yanjun Cai, Genhong Cheng, Yanfang Jiang
Summary: This study demonstrates that pegylated interferon alpha (PEG-IFN-alpha) improves the seroconversion rate of hepatitis B surface antigen (HBsAg) in patients with chronic hepatitis B (CHB) by stimulating CD40L-expressing T follicular helper (TFH) cells.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiang-An Zhao, Jian Wang, Jiacheng Liu, Guangmei Chen, Xiaomin Yan, Bei Jia, Yue Yang, Yong Liu, Da Gu, Zhaoping Zhang, Xiaoxing Xiang, Rui Huang, Chao Wu
Summary: The study found that the baseline serum anti-HBc level in HBeAg-positive CHB patients was a promising indicator for predicting HBeAg seroconversion after antiviral treatment.
ANTIVIRAL RESEARCH
(2021)
Article
Immunology
Bingying Du, Jiaming Teng, Rongkun Yin, Yuanyuan Tian, Tingwang Jiang, Yanan Du, Wei Cai
Summary: The study found that the frequency of T follicular helper (Tfh) cells significantly increased in HBV-ACLF patients, correlating with MELD score. Additionally, HBV-ACLF patients had higher serum levels of IL-12 and IL-21. Naive CD4(+) T cells from healthy controls differentiated into Tfh cells when exposed to serum from HBV-ACLF patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xindi Wei, Xiaoyin Niu
Summary: Tfh cells, a new subset of CD4+ T cells, mainly express CXCR5 and ICOS surface molecules, secrete IL-21, and require BCL-6 transcription factor. They exist in germinal centers (GCs) of lymphoid organs and peripheral blood, playing critical roles in B cell development, GC formation, and antibody production. Aberrant proliferation and function of Tfh cells contribute to autoimmune diseases, and they can potentially be used as therapeutic targets.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Gastroenterology & Hepatology
Florian van Boemmel, Kerstin Stein, Renate Heyne, Joerg Petersen, Peter Buggisch, Christoph Berg, Stefan Zeuzem, Andreas Stallmach, Martin Sprinzl, Eckart Schott, Anita Pathil-Warth, Ulrike von Arnim, Verena Keitel, Juergen Lohmeyer, Karl-Georg Simon, Christian Trautwein, Andreas Trein, Dietrich Hueppe, Markus Cornberg, Frank Lammert, Patrick Ingiliz, Reinhart Zachoval, Holger Hinrichsen, Alexander Zipprich, Hartmuth Klinker, Julian Schulze zur Wiesch, Anett Schmiedeknecht, Oana Brosteanu, Thomas Berg
Summary: Stopping NUC treatment can achieve a higher rate of HBsAg loss compared to continued treatment, especially for patients with end of treatment HBsAg levels <1,000 IU/ml.
JOURNAL OF HEPATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fabienne Burger, Kapka Miteva, Daniela Baptista, Aline Roth, Rodrigo A. Fraga-Silva, Catherine Martel, Nikolaos Stergiopulos, Francois Mach, Karim J. Brandt
Summary: The study shows that follicular regulatory helper T cells (T-FR) can control regulatory B cell (B-REG) populations in mice models on a high-cholesterol diet, leading to the suppression of proatherogenic processes. This suggests that T-FR cells may have atheroprotective effects by modulating immune processes related to atherosclerosis.
CARDIOVASCULAR RESEARCH
(2021)
Article
Immunology
Matthew T. T. Ollerton, Joy M. M. Folkvord, Andriana La Mantia, David A. A. Parry, Amie L. L. Meditz, Martin D. D. McCarter, Richard T. D'Aquila, Elizabeth Connick
Summary: Follicular helper CD4(+) T cells (TFH) are major sites of HIV replication, but follicular regulatory CD4(+) T cells (TFR) limit HIV replication by suppressing TFH through IL-2 restriction. TFR reduce TFH viability and HIV infected TFH, and IL-2 enhances TFH viability but decreases HIV replication in the presence of TFR.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chun-Shu Wong, Clarisa M. Buckner, Silvia Lucena Lage, Luxin Pei, Felipe L. Assis, Eric W. Dahlstrom, Sarah L. Anzick, Kimmo Virtaneva, Adam Rupert, Jeremy L. Davis, Ting Zhou, Elizabeth Laidlaw, Maura Manion, Frances Galindo, Megan Anderson, Catherine A. Seamon, Michael C. Sneller, Andrea Lisco, Claire Deleage, Stefania Pittaluga, Susan Moir, Irini Sereti
Summary: Low nadir CD4 T-cell counts in HIV+ patients are associated with high morbidity and mortality, and lasting immune dysfunction. In severely lymphopenic HIV+ patients, early events of immune recovery have not been fully characterized. Post-ART, there were signs of immune reconstitution with an increase in LN germinal center cells, although limited in functionality.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhen Xun, Jinpiao Lin, Qingqing Yu, Can Liu, Jinlan Huang, Hongyan Shang, Jianhui Guo, Yuchen Ye, Wennan Wu, Yongbin Zeng, Songhang Wu, Siyi Xu, Tianbin Chen, Jing Chen, Qishui Ou
Summary: Bile acids (BAs), especially taurocholic acid (TCA), are significantly elevated in HBeAg-positive chronic hepatitis B (CHB) patients and inhibit the response to pegylated interferon-alpha (PegIFN alpha) therapy. These BAs reduce the number, proportion, and effector functions of CD3(+)CD8(+) T cells and natural killer (NK) cells in CHB patients.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Virology
Yandi Xie, Hui Ma, Bo Feng, Guangjun Song
Summary: By analyzing the follow-up data of chronic hepatitis B patients, this study found that changes in serum HBsAg and HBcrAg levels, as well as specific gene mutations, were associated with spontaneous HBeAg seroconversion.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Mingjuan Yin, Yongzhen Xiong, Lingfeng Huang, Gang Liu, Zuwei Yu, Yi Zhao, Jie Zhao, Yan Zhang, Tingyu Lian, Jingxiao Huang, DongMei Liang, JinMei Zeng, Jindong Ni
Summary: This study investigates the immune response to hepatitis B vaccination and finds similar kinetics between circulating Tfh cells and splenic Tfh cells; cTfh cells are positively correlated with anti-HBs at one week after vaccination; in vitro experiments show preferential activation of CXCR3(-)Tfh cell subsets in peripheral blood mononuclear cells stimulated by HBsAg.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Virology
Maria Mercedes Elizalde, Cecilia Graciela Giadans, Rodolfo Hector Campos, Diego Martin Flichman
Summary: This study found that HBeAg-negative patients have a higher frequency of HBc mutations, which can impact various stages of viral replication and modulate the replication of hepatitis B virus during the HBeAg-negative stage of infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Critical Care Medicine
Laura Bauer, Lisa Jasmin Mueller, Sarah M. Volkers, Frederik Heinrich, Mir-Farzin Mashreghi, Clemens Ruppert, Leif E. Sander, Andreas Hutloff
Summary: Pulmonary sarcoidosis is driven not only by T-helper type 1 cells and macrophages, but also by T follicular helper-like cells and germinal center-like reactions in the inflamed lung tissue. This new pathomechanism of active T-cell/B-cell cooperation and local production of potentially pathogenic antibodies should be taken into consideration for diagnosis and treatment.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Immunology
Yisi Lu, Joe Craft
Summary: T follicular regulatory cells are a unique subset of regulatory T cells that migrate to B cell follicles and germinal centers to maintain immune homeostasis. They use specific transcription factors to regulate immune responses, promoting humoral immunity and memory following viral infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Taiyu He, Yingzhi Zhou, Pan Xu, Ning Ling, Min Chen, Tianquan Huang, Biqiong Zhang, Ziqiao Yang, Ling Ao, Hu Li, Zhiwei Chen, Dazhi Zhang, Xiaofeng Shi, Yu Lei, Zhiyi Wang, Weiqun Zeng, Peng Hu, Yinghua Lan, Zhi Zhou, Juan Kang, Ying Huang, Tongdong Shi, Qingbo Pan, Qian Zhu, Xiping Ran, Yingzhi Zhang, Rui Song, Dejuan Xiang, Shuang Xiao, Gaoli Zhang, Wei Shen, Mingli Peng, Dachuan Cai, Hong Ren
Summary: This study investigated the safety and antibody responses of COVID-19 vaccination in patients with chronic hepatitis B (CHB) virus infection. The results showed that the vaccine was well tolerated and induced effective antibody responses in CHB patients.
LIVER INTERNATIONAL
(2022)
Letter
Virology
Hu Li, Zhiwei Chen, Xiaoqing Liu, Peng Hu
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Hu Li, Yuting Wang, Ling Ao, Mingxia Ke, Zhiwei Chen, Min Chen, Mingli Peng, Ning Ling, Peng Hu, Dachuan Cai, Dazhi Zhang, Hong Ren
Summary: This study investigated the antibody and B cell responses to inactivated SARS-CoV-2 vaccination in patients with autoimmune liver disease (AILD). The results showed that AILD patients had significantly lower titers of antibodies and lower seropositivity rates of neutralizing antibodies compared to healthy controls. Immunosuppressive therapy was identified as an independent risk factor for poor antibody responses in AILD patients. However, there was no significant difference in SARS-CoV-2-specific memory B cell responses between the AILD and healthy control groups.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Hu Li, Dachuan Cai, Depeng Jiang, Xingsheng Li, Xiaohui Liao, Dongfang Liu, Zuojin Liu, Peng Zhu, Guobing Yin, Jia Ming, Mingli Peng, Min Chen, Ning Ling, Yinghua Lan, Dazhi Zhang, Peng Hu, Hong Ren
Summary: Heterogeneity of antibody responses has been observed in SARS-CoV-2 vaccination recipients with underlying diseases. The presence of comorbidities significantly affects the humoral response to SARS-CoV-2 vaccination in patients with chronic disease. Patients with certain chronic diseases show impaired humoral responses following SARS-CoV-2 vaccination.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Hu Li, Shiyin Li, Pan Xu, Xiaohao Wang, Huan Deng, Yu Lei, Shan Zhong
Summary: This study evaluated the neutralizing antibody response after COVID-19 vaccination in hospitalized patients with liver dysfunction. It was found that patients with liver dysfunction had significantly lower levels of neutralizing antibodies compared to healthy controls, and factors such as male sex, severe liver injury, and chronic liver diseases were associated with poor antibody responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qian Zhu, Yingzhi Zhang, Juan Kang, Zhiwei Chen, Mingli Peng, Min Chen, Gaoli Zhang, Dejuan Xiang, Shuang Xiao, Hu Li, Ying Mei, Jie Yang, Xiaoya Qi, Dachuan Cai, Hong Ren
Summary: This study investigated the effect of obesity on the immune response to COVID-19 vaccines. The results showed that individuals with obesity had a weaker immune response, with lower antibody levels and reduced B and T cell responses.
Article
Virology
Zhiwei Chen, Tianquan Huang, Taiyu He, Guanhua Zha, Qian Zhu, Gaoli Zhang, Dejuan Xiang, Min Chen, Hu Li, Ning Ling, Yinghua Lan, Xiaofeng Shi, Dazhi Zhang, Pan Xu, Qingbo Pan, Rui Song, Junxiong Cao, Yingzhi Zhang, Hongyan Xiang, Yali Feng, Ziqiao Yang, Biqiong Zhang, Wei Shen, Dachuan Cai, Mingli Peng, Peng Hu, Hong Ren
Summary: Given the pandemic of Omicron variants, booster vaccination with inactivated virus vaccines has been implemented in China. This study aimed to explore immune responses after booster vaccination in patients with chronic hepatitis B virus infection. Results showed that booster vaccination significantly enhanced antibody responses against the wild type virus, but resulted in compromised responses against the Omicron variant. These findings highlight the need for further research on all-in-one vaccines and optimal vaccination strategies.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Feng Xiang, Boyu Long, Jiaoxia He, Feifei Cheng, Sijing Zhang, Qing Liu, Zhiwei Chen, Hu Li, Min Chen, Mingli Peng, Wenwei Yin, Dongfang Liu, Hong Ren
Summary: This study investigates the safety, antibody responses, and B-cell immunity in patients with type 2 diabetes mellitus (T2DM) after receiving inactivated COVID-19 vaccines. The results show that the vaccines are safe in T2DM patients, but the antibody responses and memory B-cell responses are significantly decreased compared to healthy individuals.
Article
Gastroenterology & Hepatology
Xiao-hao Wang, Bin-bin Peng, Lu Zhang, Jing Zhao, Li Zhang, Hong Ren, Peng Hu, Hu Li, Shan Zhong
Summary: This study compared the effects of mixed using different modes of ALS (MALS) and single using one mode of ALS (SALS) on the 28- and 90-day survival rates of ACLF patients. The results showed that the MALS group had significantly lower 28- and 90-day mortalities compared to the SALS group, especially in advanced stages of the disease.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Infectious Diseases
Qiao Tang, Zhiwei Chen, Hu Li, Li Zhang, Mingli Peng, Yi Zeng, Xiaoqing Liu, Zubi Liu, Peng Hu
Summary: This study investigated the distribution of HCV genotypes in Chinese mainland and performed phylogenetic analysis to provide an up-to-date understanding of the molecular epidemiology of genotypes.
INFECTIOUS DISEASES OF POVERTY
(2023)
Article
Infectious Diseases
Shiying Li, Jin Tong, Hu Li, Chenxue Mao, Wei Shen, Yu Lei, Peng Hu
Summary: We present a case of a 34-year-old woman with multiple joint pain. Initial consideration of autoimmune diseases was supported by positive anti-Ro antibody and knee joint effusion. Subsequent chest CT scan revealed bilateral lung interstitial changes and mediastinal lymphadenopathy. Despite negative pathological findings in blood, sputum, and bronchoalveolar lavage fluid, empirical quinolone therapy was initiated. Ultimately, Legionella pneumophila was identified using target next-generation sequencing (tNGS), emphasizing the timely use of this new tool for early therapy in atypical infections.
INFECTION AND DRUG RESISTANCE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Jing Zhang, Xiaoqing Liu, Hu Li, Peng Hu
Meeting Abstract
Gastroenterology & Hepatology
Hu Li, Yuting Wang, Ling Ao, Mingxia Ke, Zhi-wei Chen, Min Chen, Ming-Li Peng, Ning Ling, Peng Hu, Dachuan Cai, Dazhi Zhang, Hong Ren
JOURNAL OF HEPATOLOGY
(2022)
Letter
Biochemistry & Molecular Biology
Zhiwei Chen, Yingzhi Zhang, Rui Song, Lu Wang, Xiaoxiao Hu, Hu Li, Dachuan Cai, Peng Hu, Xiaofeng Shi, Hong Ren
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Gastroenterology & Hepatology
Xiaoqing Liu, Hu Li, Li Wei, Qiao Tang, Peng Hu
Summary: This study compared the performance of GPR, APRI, and FIB-4 in evaluating liver fibrosis stages and identified optimized cutoffs to exclude cirrhosis. The study found that GPR outperformed APRI in predicting cirrhosis. The new GPR score could rule out more patients without cirrhosis compared to APRI and FIB-4.
HEPATOLOGY COMMUNICATIONS
(2022)