Histone methyltransferase SETD2 inhibits M1 macrophage polarization and glycolysis by suppressing HIF-1α in sepsis-induced acute lung injury

Tumor Cell‐Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis

(2022) Ningning Niu et al.   Advanced Science

The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9

(2021) Yao Tong et al.   Cell Death & Disease

The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis

(2021) Min Liu et al.   Redox Biology

Norisoboldine Attenuates Sepsis-Induced Acute Lung Injury by Modulating Macrophage Polarization via PKM2/HIF-1α/PGC-1α Pathway

(2021) Qi Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Pravastatin attenuates sepsis-induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of Cav-1/eNOS pathway

(2021) Yi Ren et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

LncRNA TUG1 alleviates sepsis-induced acute lung injury by targeting miR-34b-5p/GAB1

(2020) Nan Qiu et al.   BMC Pulmonary Medicine

Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3

(2020) Zehua Wang et al.   JOURNAL OF IMMUNOLOGY

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Attenuate LPS-Induced ARDS by Modulating Macrophage Polarization Through Inhibiting Glycolysis in Macrophages

(2020) Huimin Deng et al.   SHOCK

Sodium–glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice

(2020) Ting Cai et al.   Cell Death & Disease

SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

(2020) Huairui Yuan et al.   CANCER CELL

Protective effects of P2X 7 R antagonist in sepsis‐induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression

(2020) Zijun Zou et al.   JOURNAL OF GENE MEDICINE

PRKAR2B‐HIF‐1α loop promotes aerobic glycolysis and tumour growth in prostate cancer

(2020) Lei Xia et al.   CELL PROLIFERATION

The Degree of Helicobacter pylori Infection Affects the State of Macrophage Polarization through Crosstalk between ROS and HIF-1α

(2020) Ying Lu et al.   Oxidative Medicine and Cellular Longevity

Neutrophils Disturb Pulmonary Microcirculation in Sepsis-induced Acute Lung Injury

(2019) Inwon Park et al.   EUROPEAN RESPIRATORY JOURNAL

SETD2 indicates favourable prognosis in gastric cancer and suppresses cancer cell proliferation, migration, and invasion

(2018) Ziyi Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ecto-5′-nucleotidase (CD73) attenuates inflammation after spinal cord injury by promoting macrophages/microglia M2 polarization in mice

(2018) Shun Xu et al.   Journal of Neuroinflammation

Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages

(2018) Marcella E. O'Reilly et al.   MOLECULAR NUTRITION & FOOD RESEARCH

H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells

(2018) Lijun Wang et al.   PLOS BIOLOGY

Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis

(2017) Huairui Yuan et al.   JOURNAL OF CLINICAL INVESTIGATION

LSD1 demethylates HIF1α to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis

(2017) J-Y Lee et al.   ONCOGENE

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Effects of HIF prolyl-hydroxylase-2 gene silencing on HCG-induced vascular endothelial growth factor expression in luteal cells

(2015) Z.H. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

HIF-2 Inhibition Supresses Inflammatory Responses and Osteoclastic Differentiation in Human Periodontal Ligament Cells

(2015) Won-Jung Bae et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor

(2012) Xin-Jiang Lu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunomodulatory therapy for sepsis: an update

(2011) Eirini Christaki et al.   Expert Review of Anti-Infective Therapy

An Intact Canonical NF- B Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia

(2010) S. F. Fitzpatrick et al.   JOURNAL OF IMMUNOLOGY

The sepsis seesaw: tilting toward immunosuppression

(2009) Richard S Hotchkiss et al.   NATURE MEDICINE