Review
Rheumatology
Manil Subesinghe, Shaheel Bhuva, Nikita Arumalla, Andrew Cope, David D'Cruz, Sujith Subesinghe
Summary: 2-deoxy-2[F-18]fluoro-D-glucose (FDG) PET-CT has revolutionized oncological imaging, and it is also widely used in the diagnosis and treatment of infectious and inflammatory diseases. Rheumatological diseases, which can affect multiple sites within the musculoskeletal system, can be accurately diagnosed and treated using FDG PET-CT.
Article
Biochemical Research Methods
Filipa Mota, Patricia De Jesus, Sanjay K. Jain
Summary: Researchers developed a method to synthesize F-18-FDS for positron emission tomography imaging to visualize infections. Clinical study in 26 patients showed that F-18-FDS PET was safe and could differentiate infections caused by Enterobacterales from other pathologies such as sterile inflammation or cancer.
Article
Veterinary Sciences
Su-Hyeon Kim, Sungin Lee
Summary: This case report describes the characteristics of 18F-FDG PET-CT imaging in a dog with an abdominal gossypiboma, which has not been reported in the veterinary literature before. A 13-year-old, spayed, female mixed breed dog underwent mastectomy and ovariohysterectomy and was referred for evaluation of metastasis after surgery. F-18-deoxy-2-D-glucose positron emission tomography/computed tomography (18F-FDG PET-CT) was performed and a soft-tissue mass was observed in the abdominal cavity.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Infectious Diseases
Patricia Sola Penna, Sergio Augusto Lopes De Souza, Paulo Gustavo Limeira Nobre De Lacerda, Izabela Jardim Rodrigues Pitta, Clarissa Neves Spitz, Ana Maria Sales, Flavio Alves Lara, Ana Caroline Siquara De Souza, Euzenir Nunes Sarno, Roberta Olmo Pinheiro, Marcia Rodrigues Jardim
Summary: This study used 18F-FDG PET/CT to evaluate the peripheral nerves of nine leprosy patients and found that the uptake of 18F-FDG correlates with clinical neuritis. The results suggest that 18F-FDG PET-CT could be a useful tool to confirm neuritis, especially in difficult-to-diagnose cases.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonio Canosa, Alessio Martino, Umberto Manera, Rosario Vasta, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Francesca Di Pede, Vincenzo Arena, Cristina Moglia, Alessandro Giuliani, Andrea Calvo, Adriano Chio, Marco Pagani
Summary: This study aimed to evaluate the accuracy of brain 2-[F-18]fluoro-2-deoxy-D-glucose-positron-emission tomography (2-[F-18]FDG-PET) as a predictor of survival in patients with amyotrophic lateral sclerosis (ALS). The results showed that brain 2-[F-18]FDG-PET, combined with artificial intelligence, could accurately predict the survival time range in ALS patients. This prognostic tool has potential applications in patient management and individual stratification in clinical trials.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonio Canosa, Andrea Calvo, Cristina Moglia, Umberto Manera, Rosario Vasta, Francesca Di Pede, Sara Cabras, Davide Nardo, Vincenzo Arena, Maurizio Grassano, Fabrizio D'Ovidio, Koen Van Laere, Philip Van Damme, Marco Pagani, Adriano Chio
Summary: This study used brain(18)F-FDG-PET to assess the brain metabolic correlates of ALS with different King's stages. The results indicated an inverse correlation between brain metabolism and King's stages in ALS patients, with significant differences among different stages.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Chemistry, Physical
Paul M. DeMent, Chenlu Liu, Joseph Wakpal, Richard N. Schaugaard, H. Bernhard Schlegel, Hien M. Nguyen
Summary: Phenanthroline is a commonly used bidentate ligand in coordination chemistry, which can be tuned to develop efficient and stereoselective catalysts. By activating 2-deoxy-2-fluoro glycosyl halides with phenanthroline-based catalysts, glycosylations with high levels of alpha-selectivities and moderate to high yields can be achieved. The proposed mechanism for this catalytic glycosylation system involves double S(N)2 displacement pathways with phenanthroline catalysts, ensuring stereoselective formation of alpha-1,2-cis-2-fluoro glycosides.
Article
Chemistry, Organic
Yuliya Dantsu, Ying Zhang, Wen Zhang
Summary: In this study, a chemically derivatized 2'-deoxy-2'-fluoro-L-uridine building block was synthesized and incorporated into oligonucleotides. Thermo-denaturization and enzymatic digestion experiments showed superior stability of the modified molecules. The crystal structure of L-type fluoro-DNA was determined, revealing increased L-helix stability through fluoro-modification and laying the foundation for potential functional applications.
Article
Multidisciplinary Sciences
Pauline Bourigault, Michael Skwarski, Ruth E. Macpherson, Geoff S. Higgins, Daniel R. McGowan
Summary: This study investigated the correlation between 2-hour and 4-hour post-injection FMISO-PET imaging in NSCLC patients and found that imaging at 4 hours after injection provided better results. There was a strong correlation between the results of the 2-hour and 4-hour scans in overall tumors, but the correlation decreased from the center to the edge in tumor subregions.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Darren Cowzer, Fergus Keane, Geoffrey Y. Ku
Summary: Esophageal adenocarcinoma, especially adenocarcinoma of the gastroesophageal junction, is rare but its incidence is rising in young adults, and the prognosis is generally poor. Despite advances in multimodality treatments for locally advanced disease, most patients still develop metastatic disease with suboptimal long-term outcomes. PET-CT has emerged as a key tool for managing this disease, and its role has been evaluated in various studies. This review focuses on the use of PET-CT for staging, prognostication, PET-CT guided neoadjuvant therapy, and surveillance of locally advanced esophageal and GEJ adenocarcinoma.
Article
Medicine, General & Internal
Jianhua Qin, Yu Tang, Bao Wang
Summary: This study explores the feasibility of generating regional F-18-fluoromisonidazole (F-18-FMISO) positron emission tomography (PET) images using advanced magnetic resonance (MR) images and their predictive value for survival in glioblastoma patients. It demonstrates that multiple advanced MR images can be used to generate qualified regional F-18-FMISO PET images using neural networks. The generated images have predictive value in the prognostic evaluation of glioblastoma.
Article
Cardiac & Cardiovascular Systems
Hope A. Feldman, Jeremy J. Erasmus, Nicolas Zhou, Mara B. Antonoff, Reza J. Mehran, Ravi Rajaram, David C. Rice, Boris Sepesi, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh, Wayne L. Hofstetter, Sonia L. Betancourt Cuellar
Summary: This study aimed to determine the significance of increased FDG uptake in hilar nodes in patients with potentially curable, locally advanced esophageal cancer. The findings showed that increased FDG uptake in hilar nodes did not indicate nonregional nodal metastasis, and these patients should be treated with curative intent. The need for biopsy of FDG-avid hilar nodes in this cohort should be carefully considered.
ANNALS OF THORACIC SURGERY
(2022)
Article
Chemistry, Inorganic & Nuclear
Maja Chochevska, Marija Atanasova Lazareva, Katerina Kolevska, Maja Velichkovska, Jacek Koziorowski, Emilija Janevik Ivanovska, Bistra Angelovska, Ana Ugrinska
Summary: This study aimed to develop a synthesis method for [F-18]FMISO using the Synthera module and solid phase extraction (SPE) Sep-Pak purification cartridges. [F-18]FMISO was synthesized under different reaction conditions and purified using various reversed-phase purification cartridges. The synthesized [F-18]FMISO was retained on the cartridge, while impurities passed through and were collected as waste. The retained [F-18]FMISO was eluted with ethanol and water, and the eluates were collected as the final product. Quality control tests were performed on the product sample, while chemical and radiochemical tests were conducted on the waste sample.
Article
Chemistry, Medicinal
Mieke Guinan, Ningwu Huang, Mark Smith, Gavin J. Miller
Summary: The study developed a new class of nucleoside analogues with good activity against Hepatitis C replicon, which is significant in the field of antiviral drug research.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Leilei Jiang, Ting Pan, Qin Lv, Wenmin Yuan, Xiaochun Liu, Xianjun Qu, Dongdong Luo, Shengbiao Wan, Shuxiang Cui
Summary: ProTide prodrug technology shows promising potential for the development of anti-cancer drugs for liver cancer. The synthesized 3'ester ProTide prodrugs of FdUR demonstrated high activity against liver cancer cells with improved selectivity and stability. Specifically, prodrug 11b showed significant suppression of tumor growth in vivo without toxicity, making it a safe and effective prodrug for liver cancer therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Hannah Zaryouh, Ines De Pauw, Hasan Baysal, Marc Peeters, Jan Baptist Vermorken, Filip Lardon, An Wouters
Summary: Resistance to therapies targeting EGFR in HNSCC is a major challenge, with redundant activation of the PI3K/Akt pathway proposed as a key driver of resistance. Understanding the role of key proteins in this pathway is crucial for developing effective combination strategies. Studies on PI3K/Akt pathway inhibitors show promise in overcoming this resistance and improving clinical efficacy by co-targeting EGFR and PI3K/Akt pathways.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniele Bertoglio, Jeroen Verhaeghe, Leonie Wyffels, Alan Miranda, Sigrid Stroobants, Ladislav Mrzljak, Celia Dominguez, Mette Skinbjerg, Jonathan Bard, Longbin Liu, Ignacio Munoz-Sanjuan, Steven Staelens
Summary: This study used C-11-UCB-J PET imaging to detect SV2A deficits in the brains and spinal cords of symptomatic HD mice, suggesting it could be a novel marker of synaptic integrity.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Orthopedics
Sharjeel Usmani, Najeeb Ahmed, Gopinath Gnanasegaran, Fahad Marafi, Tim van den Wyngaert
Summary: Mineral metabolism and bone diseases are common in CKD patients, with F-18-NaF PET/CT being a superior method for assessing skeletal metabolism. This bone-specific tracer is likely to be used more regularly for clinical assessment and quantitation of bone kinetics in CKD patients, offering a non-invasive and specific approach.
SKELETAL RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniele Bertoglio, Jeroen Verhaeghe, Alan Miranda, Leonie Wyffels, Sigrid Stroobants, Ladislav Mrzljak, Vinod Khetarpal, Mette Skinbjerg, Longbin Liu, Celia Dominguez, Ignacio Munoz-Sanjuan, Jonathan Bard, Steven Staelens
Summary: The study demonstrated that the novel radioligand [C-11]CHDI-626 is suitable for mHTT PET imaging. Longitudinal quantification revealed genotype differences, with an increase in signal in HET mice associated with mHTT aggregate load progression.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
W. U. Kampen, B. Boddenberg-Paetzold, M. Fischer, M. Gabriel, R. Klett, M. Konijnenberg, E. Kresnik, H. Lellouche, F. Paycha, L. Terslev, C. Turkmen, F. van der Zant, L. Antunovic, E. Panagiotidis, G. Gnanasegaran, T. Kuwert, T. Van den Wyngaert
Summary: Radiosynoviorthesis is a treatment method using intraarticular application of beta-particle emitting radiocolloids for inflammatory joint diseases. These guidelines aim to assist nuclear medicine physicians in performing radiosynoviorthesis, addressing legislative issues, dosimetric considerations, complications, and side effects. However, differences in approved radiopharmaceuticals and indications between European countries mean the guidelines must be individualized.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Obstetrics & Gynecology
Wiebren A. A. Tjalma, Jaques van Heerden, Tim Van den Wyngaert
Summary: Since the introduction of HPV vaccination, countries with high vaccination coverage have seen a decrease in precancerous cervical lesions. However, women with these lesions are often not vaccinated or not given the latest vaccine. Vaccination can reduce the risk of recurrence and understanding its importance in these cases is beneficial. The ideal timing for vaccination, either before or after surgery, is yet to be determined.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Critical Care Medicine
Niels Van Regenmortel, Thomas Langer, Tim De Weerdt, Ella Roelant, Manu Malbrain, Tim Van den Wyngaert, Philippe Jorens
Summary: This study analyzed the physiological handling of sodium burden induced by maintenance fluids and found that compared to a regimen resembling a healthy dietary sodium intake, especially in a clinical setting, sodium-rich maintenance fluids lead to prolonged fluid retention. The kidneys adapt to sodium-rich fluids by altering sodium excretion and concentrating urine to retain additional free water.
JOURNAL OF CRITICAL CARE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniele Bertoglio, Nicolas Halloin, Stef De Lombaerde, Aleksandar Jankovski, Jeroen Verhaeghe, Charles Nicaise, Steven Staelens
Summary: This study explored the use of synaptic vesicle glycoprotein 2A (SV2A) PET imaging for noninvasively detecting spinal cord lesions after spinal cord injury (SCI). The results showed that C-11-UCB-J PET/CT imaging is a valuable tool for evaluating SCI, and SV2A PET may provide an objective measure of SCI. The use of SV2A PET imaging in clinical assessment of SCI is highly recommended.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Tim van den Wyngaert, Stijn de Schepper, Filipe Elvas, Seyedeh S. Seyedinia, Mohsen Beheshti
Summary: Compared to PET/CT, the uptake of PET-MRI has been slow in clinical practice. However, in musculoskeletal research, PET-MRI offers attractive advantages such as exquisite soft-tissue detail, superior bone marrow visualization, and a wide range of assessment methods. PET inserts for small-animal MRI machines have been successful in the preclinical setting. Multimodality probes have been developed to simultaneously query different metabolic pathways. Encouraging results with novel radiotracers suggest high potential for PET/MRI in MSK conditions.
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Pharmacology & Pharmacy
Jonatan Dewulf, Ivanna Hrynchak, Sarah Geudens, Isabel Pintelon, Christel Vangestel, Jose Sereno, Peter A. van Dam, Antero J. Abrunhosa, Filipe Elvas, Tim Van den Wyngaert
Summary: This study developed a novel radiolabeled RANKL PET imaging agent that allows fast tumor accumulation and improved imaging contrast compared to its antibody counterpart. This imaging agent shows promise as a potential PET RANKL imaging tool for future clinical applications.
Article
Oncology
Yanina Dockx, Christel Vangestel, Sven De Bruycker, Tim Van den Wyngaert, Manon Huizing, Steven Staelens, Sigrid Stroobants
Summary: This study evaluated F-18-FDG and F-18-FLT as early-response biomarkers for PI3K/Akt/mTOR inhibition in breast cancer models. The results showed that F-18-FLT PET detects responses to PI3K-targeting therapy earlier than F-18-FDG PET. However, therapy response may be underestimated after treatment with trastuzumab and everolimus due to negative feedback loop and crosstalk between pathways.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
John C. Dickson, Ian S. Armstrong, Pablo Minguez Gabina, Ana M. Denis-Bacelar, Aron K. Krizsan, Jonathan M. Gear, Tim Van den Wyngaert, Lioe-Fee De Geus-Oei, Ken Herrmann
Summary: This document provides guidelines for nuclear medicine departments to establish and develop their quantitative SPECT-CT service, including protocols, harmonization, and clinical use cases. These guidelines were written by members of the European Association of Nuclear Medicine and have been approved and endorsed by the association.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Catalina Moreno-Rabie, Laurence Lapauw, Hugo Gaeta-Araujo, Andre Ferreira-Leite, Wim Coucke, Tim van den Wyngaert, Reinhilde Jacobs
Summary: This study aimed to identify radiographic predictors of MRONJ in panoramic images of oncologic patients undergoing tooth extraction. The results showed that longer ARD treatment, teeth with absent or incomplete endodontic fillings, presence of caries, widened periodontal ligament space and/or periapical lesions, as well as sclerotic and heterogenous bone patterns were associated with a higher risk of MRONJ development.
SCIENTIFIC REPORTS
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Jonatan Dewulf, Ivanna Hrynchak, Alexandra Fonseca, Magda Silva, Christel Vangestel, Sergio do Carmo, Jose Sereno, Tim Van den Wyngaert, Antero Abrunhosa, Filipe Elvas
NUCLEAR MEDICINE AND BIOLOGY
(2022)