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Biochemistry & Molecular Biology
Xifeng Xiong, Xudong Lai, Jinli Zhang, Qingqi Meng, Pengzhen Wang, Shengnan Qin, Wei Liu, Yongxuan Wang, Zhuo Yao, Di Wang, Xiaojian Li, Zhihe Liu, Haixiong Miao
Summary: Ovarian cancer is the second leading cause of cancer death in women worldwide. This study identifies FBP1 as a potential target for ovarian cancer treatment, as it is closely associated with the development of ovarian cancer and positively correlated with the expression of EZH2. Knockdown of FBP1 suppresses tumor formation and cisplatin resistance in ovarian cancer cells, suggesting its role in promoting cisplatin resistance. The physical binding between FBP1 and EZH2 is also validated in this study. These findings highlight the importance of FBP1 as a novel target for the development of ovarian cancer treatment.
BIOSCIENCE REPORTS
(2022)
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Orthopedics
Guangdi Li, Mi Zhang, Yuan Huang, Jiafei Yang, Lianghong Dong, Hao Shi, Long Li, Riguang Liu, Jiangwei Li
Summary: Abnormal expression of Core binding factor-beta in osteoarthritis cartilage is associated with decreased chondrocyte proliferation, increased apoptosis, and upregulated inflammatory response. Inhibiting Core binding factor-beta expression may potentially delay cartilage degeneration.
BMC MUSCULOSKELETAL DISORDERS
(2021)
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Multidisciplinary Sciences
Takashi Yoshino, Takahiro Suzuki, Go Nagamatsu, Haruka Yabukami, Mika Ikegaya, Mami Kishima, Haruka Kita, Takuya Imamura, Kinichi Nakashima, Ryuichi Nishinakamura, Makoto Tachibana, Miki Inoue, Yuichi Shima, Ken-ichirou Morohashi, Katsuhiko Hayashi
Summary: Novel methods have been developed to generate functional mouse oocytes from pluripotent stem cell-derived primordial germ cell-like cells (PGCLCs) and fetal ovarian somatic cell-like cells (FOSLCs). When FOSLCs are aggregated with PGCLCs, they enter meiosis and produce oocytes capable of fertilization and development into live offspring, providing a method for in vitro oocyte production and follicle generation for a better understanding of mammalian reproduction.
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Cell Biology
Mustika Rahmawati, Kassie M. Stadler, Blanca Lopez-Biladeau, Tia M. Hoisington, Nathan C. Law
Summary: This study reveals the crucial role of core-binding factor subunit-beta (CBF beta) in prepubertal development and the onset of spermatogenesis. CBF beta regulates the proliferation, survival, and overall maintenance of undifferentiated spermatogonia, as well as the meiotic progression and spermatid formation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
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Biochemistry & Molecular Biology
Roman E. Ushakov, Nikolay D. Aksenov, Natalia A. Pugovkina, Elena B. Burova
Summary: IGFBP3 plays a role in stress-induced senescence in MESCs, with results suggesting a potentially ambiguous role in this process. Variations in IGFBP3 regulation during senescence were observed in MESCs from different donors, highlighting its complexity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
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Biochemistry & Molecular Biology
Shiyun Feng, Jiabao Jia, Guangchao Lv, Yue Wang
Summary: ABCB7 is significantly upregulated in esophageal cancer tissues, and its knockdown inhibits the proliferation, migration, and invasion of cancer cells. ABCB7 silencing also induces apoptosis and non-apoptotic cell death, reverses the epithelial-mesenchymal transition, and inhibits the TGF-beta signaling pathway in esophageal cancer cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
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Medicine, Research & Experimental
Yuanzhi Chen, Zhicheng He, Shuting Yang, Cheng Chen, Wenyong Xiong, Yingying He, Shubai Liu
Summary: In this study, it was found that RUNX1 plays a crucial role in the development of high-grade serous ovarian cancer (HGSOC). It regulates apoptosis and EMT function, impacting the physiological function of ovarian cancer cells. Down-regulation of RUNX1 increases sensitivity to drug therapy for ovarian cancer. This research has significant implications for the diagnosis and treatment of HGSOC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
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Oncology
Ching-Hu Wu, Chien-Wei Feng, Chiu-Lin Wang, Zhi-Hong Wen, Cheng-Yu Long, Feng-Hsiang Tang
Summary: Our data showed that cisplatin treatment induces production of reactive oxygen species (ROS) that regulate apoptotic protein expression and stimulate anti-oxidative signal, inhibiting cell migration. The intervention of Zfp90 enhanced apoptosis pathway and inhibited migrative pathway, thus regulating the sensitivity of ovarian cancer cells to cisplatin. This study suggests that loss of Zfp90 function promotes cisplatin sensitization in ovarian cancer cells through the regulation of Nrf2/HO-1 pathway, enhancing cell apoptosis and inhibiting migration.
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Cell Biology
Bin Yuan, Jing Yang, Louis Dubeau, Yanfen Hu, Rong Li
Summary: The study identified the crucial role of an ER beta-specific phosphotyrosine residue in mouse ovarian development and function, with mutant mice showing reduced fertility and decreased ovarian cell proliferation. These findings provide strong genetic and molecular evidence for the impact of isotype-specific ER beta phosphorylation in ovarian tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Robert G. Mealer, Sarah E. Williams, Maxence Noel, Bo Yang, Alexandria K. D'Souza, Toru Nakata, Daniel B. Graham, Elizabeth A. Creasey, Murat Cetinbas, Ruslan I. Sadreyev, Edward M. Scolnick, Christina M. Woo, Jordan W. Smoller, Ramnik J. Xavier, Richard D. Cummings
Summary: The missense mutation A391T in SLC39A8 is strongly associated with schizophrenia, and this study reveals its impact on protein glycosylation in the brain. This finding provides a mechanistic link between the risk allele and reversible biochemical changes, offering a new understanding of the molecular pathophysiology of schizophrenia and a potential avenue for therapeutic development.
MOLECULAR PSYCHIATRY
(2022)
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Cell Biology
Junkai Hu, Stanley Li Lin, Melitta Schachner
Summary: The expression of L1 and L1-70 is reduced in the hippocampus of AD mice. Upregulation of L1-70 can reduce amyloid plaque deposition and activate microglia. L1-70 forms a complex with Top1, regulating MIF expression, thus contributing to the clearance of A beta in AD.
CELL DEATH & DISEASE
(2022)
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Multidisciplinary Sciences
Matthew R. Evrard, Michael Li, Hui Shen, Sheryl S. Smith
Summary: Preventing pruning in the prelimbic cortex increases anxiety responses in adolescent and adult female mice, suggesting that pruning in this region is crucial for limiting anxiety in adulthood.
SCIENTIFIC REPORTS
(2021)
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Biochemistry & Molecular Biology
Xiao-Xiao Shi, He Zhang, Md Khairul Quais, Ming Chen, Ni Wang, Chao Zhang, Cungui Mao, Zeng-Rong Zhu
Summary: In this study, the cloning and functional characterization of four sphingomyelinase homologue genes from brown planthopper (BPH) were reported. Knocking down one of the genes resulted in ovarian malformation in BPH and disrupted diacylglycerol metabolism and vitellogenin accumulation, revealing the vital role of NlSMases in BPH reproductive development.
INSECT MOLECULAR BIOLOGY
(2022)
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Anatomy & Morphology
Shima Ferdos, Johannes Brockhaus, Markus Missler, Astrid Rohlmann
Summary: Communication between neurons through synapses involves the release of synaptic vesicles and dense-core vesicles. This study found that beta-Nrxns are involved in the distribution of presynaptic DCVs, providing evidence from conditional and constitutive KO mouse models.
FRONTIERS IN NEUROANATOMY
(2022)
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Medicine, Research & Experimental
Christopher H. Emfinger, Eleonora de Klerk, Kathryn L. Schueler, Mary E. Rabaglia, Donnie S. Stapleton, Shane P. Simonett, Kelly A. Mitok, Ziyue Wang, Xinyue Liu, Joao A. Paulo, Qinq Yu, Rebecca L. Cardone, Hannah R. Foster, Sophie L. Lewandowski, Jose C. Perales, Christina M. Kendziorski, Steven P. Gygi, Richard G. Kibbey, Mark P. Keller, Matthias Hebrok, Matthew J. Merrins, Alan D. Attie
Summary: The deletion of the Zfp148 gene improves glucose and amino acid sensitivity as well as insulin secretion in pancreatic beta cells. Understanding the pathways controlled by ZFP148 may offer promising strategies for enhancing beta cell function.
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Cell Biology
Birendra Mishra, Ji Yeon Park, Kahn Wilson, Misung Jo
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Endocrinology & Metabolism
Yohan Choi, Kalin Wilson, Patrick R. Hannon, Katherine L. Rosewell, Mats Brannstrom, James W. Akin, Thomas E. Curry, Misung Jo
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2017)
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Reproductive Biology
Yohan Choi, Ji Yeon Park, Kalin Wilson, Katherine L. Rosewell, Mats Brannstrom, James W. Akin, Thomas E. Curry, Misung Jo
BIOLOGY OF REPRODUCTION
(2017)