Identification of potential ACAT-2 selective inhibitors using pharmacophore, SVM and SVR from Chinese herbs

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

A method to predict different mechanisms for blood–brain barrier permeability of CNS activity compounds in Chinese herbs using support vector machine

(2016) Ludi Jiang et al.   Journal of Bioinformatics and Computational Biology

A Combined Pharmacophore Modeling, 3D QSAR and Virtual Screening Studies on Imidazopyridines as B-Raf Inhibitors

(2015) Huiding Xie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators

(2015) Maximillian A. Rogers et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Virtual Screening and Molecular Dynamics Study of Potential Negative Allosteric Modulators of mGluR1 from Chinese Herbs

(2015) Ludi Jiang et al.   MOLECULES

Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 1

(2013) Masaki Ohtawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 2

(2013) Masaki Ohtawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prediction of bioactivity of ACAT2 inhibitors by multilinear regression analysis and support vector machine

(2013) Min Zhong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 3

(2013) Masaki Ohtawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The holistic integration of virtual screening in drug discovery

(2013) Yusuf Tanrikulu et al.   DRUG DISCOVERY TODAY

Discovery of Novel Acyl Coenzyme A: Cholesterol Acyltransferase Inhibitors: Pharmacophore-Based Virtual Screening, Synthesis and Pharmacology

(2012) Mahesh T. Chhabria et al.   Chemical Biology & Drug Design

New verticilides, inhibitors of acyl-CoA:cholesterol acyltransferase, produced by Verticillium sp. FKI-2679

(2012) Taichi Ohshiro et al.   JOURNAL OF ANTIBIOTICS

Using self-organizing map (SOM) and support vector machine (SVM) for classification of selectivity of ACAT inhibitors

(2012) Ling Wang et al.   MOLECULAR DIVERSITY

Buddleja officinalis Maximowicz Extract Inhibits Lipid Accumulation on Adipocyte Differentiation in 3T3-L1 Cells and High-Fat Mice

(2012) Changhyun Roh et al.   MOLECULES

The Selectivity of Beauveriolide Derivatives in Inhibition toward the Two Isozymes of Acyl-CoA : cholesterol Acyltransferase

(2009) Taichi Ohshiro et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Carotid Atherosclerosis Progression and ACAT Inhibition

(2009) Simon Dimmitt   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia

(2009) Marijn C. Meuwese et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of Mulberry (Morus albaL.) Extracts on Lipid Homeostasis in Vitro and in Vivo

(2009) Li-Kaung Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Selective Inhibition of Acyl-CoA:cholesterol Acyltransferase 2 Isozyme by Flavasperone and Sterigmatocystin from Aspergillus Species

(2009) Kent Sakai et al.   JOURNAL OF ANTIBIOTICS

Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice

(2007) Jinmi Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY