Article
Biochemistry & Molecular Biology
Francesca Bonvicini, Alessandra Locatelli, Rita Morigi, Alberto Leoni, Giovanna Angela Gentilomi
Summary: Isatin and its derivatives are important heterocycles with various biological activities and are essential building blocks in organic synthesis. In this study, a small library of 18 isatin hybrids were synthesized and evaluated for antimicrobial potential, with two lead compounds showing inhibitory activity against S. aureus at very low concentrations.
Article
Chemistry, Applied
Nehal Mamdouh A. El-Sayed, Hany Elsawy, Mohamed Shaker S. Adam
Summary: Two iron (II) complexes of different derivatives of isatin hydrazones were synthesized and acted as catalysts for alcohol oxidation. The polar catalyst showed higher catalytic activity than the nonpolar one. Additionally, the compounds exhibited different reactivity in the interaction with DNA.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Vijai Kumar Reddy Tangadanchu, Yan-Fei Sui, Cheng-He Zhou
Summary: The isatin hybridized 1,2,4-triazole 7a developed in this study exhibited excellent inhibitory activity against E. coli, possibly by blocking DNA replication.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Review
Medicine, Research & Experimental
Emadeldin Hassan E. Konozy, Makarim El-fadil M. Osman, Amina I. Dirar, George Ghartey-Kwansah
Summary: Pathogens constantly evolve to resist medical treatments, leading to the need for new antimicrobial agents. Plant lectins, carbohydrate-binding proteins, have shown promise as drug candidates and can enhance the efficacy of obsolete antimicrobial drugs, while also modulating the immune system.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Andrey Smolobochkin, Almir S. Gazizov, Lola J. Yakhshilikova, Dmitrii D. Bekrenev, Alexander R. Burilov, Michail A. Pudovik, Anna P. Lyubina, Syumbelya K. Amerhanova, Alexandra D. Voloshina
Summary: A series of novel taurine-derived compounds with antibacterial and antifungal activity were synthesized using a modular three-stage approach. Some of the synthesized compounds showed higher activity and bactericidal effect, making them promising candidates for further studies.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Medicinal
Yun-Peng Xie, Nagarajan Sangaraiah, Jiang-Ping Meng, Cheng-He Zhou
Summary: Novel carbazole-oxadiazoles were developed as potential antibacterial agents and showed predominant inhibitory effects on both Gram-positive and -negative bacteria, especially in impeding the growth of MRSA and Pseudomonas aeruginosa ATCC 27853. The compounds exhibited low cytotoxicity and low tendency to develop resistance, and could disintegrate bacterial cell membranes to exert excellent antibacterial effects.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Mohd Imran, Abida Ash Mohd, Naira Nayeem, Saleh Ibrahim Alaqel
Summary: This study designed 14 isatin-based compounds and performed in silico studies to identify biologically active isatin derivatives. Three compounds (G, H, and L) showed promising antimicrobial activity and DNA gyrase inhibitory activity, suggesting their potential as broad-spectrum antimicrobial agents.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Sumitra Nain, Garima Mathur, Tulika Anthwal, Swapnil Sharma, Sarvesh Paliwal
Summary: In this work, several Schiff base derivatives containing isatin moiety were synthesized using two methods and their antimicrobial activity was evaluated. The results demonstrated that these newly synthesized compounds exhibited strong antimicrobial activity and showed good inhibition effect.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Alicja Warowicka, Mikolaj Koscinski, Maciej Waszczyk, Anna Gozdzicka-Jozefiak
Summary: The combination of natural plant compounds with collagen confers anti-inflammatory, antimicrobial, and antiviral activities to the material, enabling broad-spectrum applications in biomedicine.
MRS COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Mohamed Shaker S. Adam, Mohamed M. Makhlouf, Mamdouh A. Mohamed, Ahmed Desoky M. Mohamad
Summary: This study investigated the mononucleating complexes of isatin hydrazone sodium sulfonate ligand with palladium (II) and cobalt (II) ions, and proposed their catalytic reactivity in oxidation reactions as well as their bio-reactivity against bacteria, fungi, and cancer cells. The homogenous catalyst formed with cobalt ion exhibited higher efficiency compared to that with palladium ion.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Infectious Diseases
Vanessa Teixeira Marinho, Andrea Candido dos Reis, Mariana Lima da Costa Valente
Summary: The systematic review aimed to assess the effectiveness of different antimicrobial agents in reducing microorganism numbers in dentifrices for disease prevention. Chemical and herbal antimicrobial agents were commonly used in dentifrices, showing varied effectiveness in reducing microorganisms involved in oral diseases.
Article
Public, Environmental & Occupational Health
Noleen Bennett, Katherine Walker, Kirsty Buising, Ron Cheah, Xin Fang, Robyn Ingram, Rodney James, Michael J. Malloy, Karin Thursky, Leon J. Worth
Summary: The study analyzed the patterns of topical antimicrobial prescribing in Australian residential aged care facilities and found that a significant proportion of elderly patients were prescribed topical antimicrobials, with antifungals and antibiotics being the most commonly prescribed. Recommendations for antimicrobial stewardship programs in aged care facilities include appropriate use of mupirocin, prescribing first-line antimicrobial therapy for fungal infections, limiting chloramphenicol use for conjunctivitis, discouraging pro re nata orders, and ensuring review or stop dates are documented to avoid prolonged prescriptions.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Agriculture, Multidisciplinary
Pedro Alves Bezerra Morais, Karolinni B. Britto, Evandro Messias, Peterson de Andrade, Elias Werner, Adilson Vidal Costa, Valdemar Lacerda Jr, Christiano Jorge Gomes Pinheiro, Heberth de Paula, Warley de Souza Borges
Summary: To address the issues of weed infestation and herbicide resistance, the authors synthesized eight isatin derivatives using Click Chemistry. These derivatives were evaluated for their phytotoxic activity against two model plants, Lactuca sativa and Allium cepa. Six derivatives showed similar activity to the positive control trifluralin, with compound 8 being more active than trifluralin in L. sativa. ALS crystallographic structure analysis revealed the inhibitory activity of compounds 11 and 17 against A. cepa.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Polymer Science
Swati Bugalia, Yogpal Dhayal, Harshita Sachdeva, Sushama Kumari, Krishna Atal, Urmila Phageria, Pooja Saini, Om Prakash Gurjar
Summary: The role of synthetic coordination chemistry in pharmaceutical science is becoming increasingly important due to its various applications in this field. This review focuses on the synthesis, characterization, and pharmaceutical applications of macrocyclic complexes of transition metal ions containing isatin and its derivatives as ligand precursors. Isatin is a versatile compound that can be obtained from marine animals, plants, and mammalian tissues. It has a wide range of biological and pharmacological activities, making it a valuable component in drug design and synthesis. The review provides detailed information on the latest methods for the synthesis of isatin-based macrocyclic complexes and their applications in medicinal chemistry.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2023)
Review
Biology
Hafsa Qadri, Abdul Haseeb Shah, Syed Mudasir Ahmad, Bader Alshehri, Abdullah Almilaibary, Manzoor Ahmad Mir
Summary: Human infectious diseases caused by microbial pathogens continue to be a major health issue. Antimicrobial-resistant pathogens have developed resistance to existing drugs, leading to an upsurge in drug-resistant microbial species during the COVID-19 outbreak. Natural antimicrobial compounds extracted from various sources, particularly plants, show promise in combating drug tolerance and resistance. This review provides a detailed analysis of these compounds and their potential mechanisms of action against pathogenic fungi and bacteria, offering insights for improving current antimicrobial treatments and addressing the rising number of bacterial and fungal infections.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
