Article
Oncology
Yunzhi Dang, Jiao Yu, Shuhong Zhao, Ximing Cao, Qing Wang
Summary: This study reveals that elevated expression of HOXA7 is associated with metastasis and poor prognosis in KRAS mutant colorectal cancer (CRC) patients. HOXA7 overexpression enhances the metastatic ability of KRAS mutant cells and promotes the infiltration of myeloid-derived suppressor cells (MDSCs). Furthermore, blocking MDSC infiltration can effectively suppress the metastasis of KRAS mutant CRC. Therefore, interrupting the HOXA7-mediated loop may provide a promising strategy for the treatment of this disease.
CANCER CELL INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Ying Huang, Yun Guo, Yi Xu, Fei Liu, Suli Dai
Summary: In this study, the upregulation of Flotillin-1 in gastric cancer was observed and correlated with a worse prognosis. Overexpression of Flotillin-1 enhanced the migration and invasion ability of gastric cancer cells, while knockdown of Flotillin-1 inhibited metastasis. Flotillin-1 promoted gastric cancer cell metastasis through inducing EMT process.
Article
Biochemistry & Molecular Biology
Yan Luo, Qingyun Zhu, Shasha Xiang, Qi Wang, Jun Li, Xiguang Chen, Wen Yan, Jianbo Feng, Xuyu Zu
Summary: A novel metastasis suppressive circular RNA, circPOKE, has been identified in breast cancer. circPOKE binds to USP10 and reduces its binding to Snail, thereby affecting Snail stability and inhibiting the metastatic potential of breast cancer cells through the protein-ubiquitination degradation pathway. Additionally, circPOKE can be secreted into the extracellular space via exosomes and significantly inhibits the invasive capabilities of breast cancer cells. These findings suggest that circPOKE may serve as a potential therapeutic target for breast cancer metastasis.
Article
Biochemistry & Molecular Biology
Xirui Fan, Jinyi Zhou, Xiaowen Bi, Juanjuan Liang, Shuai Lu, Xintong Yan, Lan Luo, Zhimin Yin
Summary: L-theanine has been shown to inhibit invasion and migration of prostate cancer cells, as well as increase cell-cell adhesion. It also suppresses the epithelial-mesenchymal transition process in PCa. Through downregulating certain proteins and inhibiting specific signaling pathways, L-theanine shows therapeutic potential for metastatic prostate cancer.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Medicine, General & Internal
Katarzyna Wieczorek-Szukala, Andrzej Lewinski
Summary: Despite the usually indolent behavior and relatively good overall prognosis of thyroid carcinomas, they can exhibit high invasiveness and metastatic tendencies in some cases. The zinc-finger transcription factor Snail-1 is a well-known regulator of cancer invasiveness, playing a key role in inducing EMT and regulating chemoresistance and CSC formation in thyroid cancer cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Cell Biology
Jiao Wu, Yunpeng Wang, Yichun Yang, Fuqiang Liu, Jun Chen, Zhongxiang Jiang, Zheng Jiang
Summary: The study revealed that TNFSF9 promotes metastasis in pancreatic cancer, potentially through the Wnt/Snail signaling pathway and polarization of macrophages into the M2 phenotype.
Article
Oncology
Yuanyuan Jiang, Hanxiang Zhan, Yuqing Zhang, Jingxuan Yang, Mingyang Liu, Chao Xu, Xiao Fan, Junxia Zhang, Zhijun Zhou, Xiuhui Shi, Rajagopal Ramesh, Min Li
Summary: The study revealed that ZIP4 is overexpressed in NSCLC tissues, correlating with poor survival rates. Overexpressed ZIP4 promotes cell migration, invasion, and metastasis, associated with the Snail-N-cadherin signaling axis.
Article
Chemistry, Multidisciplinary
Yang Li, Bo-xue Ren, Hong-mei Li, Tao Lu, Rong Fu, Zhao-qiu Wu
Summary: Omeprazole directly binds to Snail protein and inhibits its acetylation and promotes degradation, leading to suppression of cancer cell invasion, metastasis, and tumor growth. This study suggests Omeprazole may serve as an excellent auxiliary drug for treating patients with malignant tumors.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Medicine, Research & Experimental
Ambre Giguelay, Evgenia Turtoi, Lakhdar Khelaf, Guillaume Tosato, Ikrame Dadi, Tommy Chastel, Marie-Alix Poul, Marine Pratlong, Stefan Nicolescu, Dany Severac, Antoine Adenis, Olivia Sgarbura-Popescu, Sebastien Carrere, Philippe Rouanet, Marc Ychou, Francois Quenet, Didier Pourqier, Pierre-Emmanuel Colombo, Andrei Turtoi, Jacques Colinge
Summary: This study confirms the heterogeneity of CRC-LM CAFs through single-cell transcriptomic analysis and proposes a model for recruiting different origins of CAFs to the liver in different liver malignancies. Additionally, the study finds that targeting LTBP2 with antibodies may help deplete ECM-remodeling CAFs in CRC-LMs.
Article
Cell Biology
Mengya Guo, Hao Zhuang, Jianing Huang, Xiaowen Shao, Nan Bai, Minghe Li, Minmin Niu, Wen Wei, Li Sun, Yongmei Li, Zhaoyan Qiang
Summary: This study explored the role of lncRNA LINC02870 in tumorigenesis and metastasis and found that LINC02870 may be a potential oncogene in hepatocellular carcinoma (HCC). LINC02870 was upregulated in HCC tissues and overexpression of LINC02870 promoted the growth, migration, and invasion of HCC cells. Further analysis identified EIF4G1 as the binding protein of LINC02870, and LINC02870 increased the translation of SNAIL to induce malignant phenotypes in HCC cells. Higher expression levels of LINC02870 and EIF4G1 correlated with poor prognosis and tumor progression in HCC patients.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Jugang Wu, Hongjuan Chai, Haiyan Shan, Chunpeng Pan, Xin Xu, Wenpei Dong, Jiwei Yu, Yan Gu
Summary: SETD1A promotes migration and invasion of gastric cancer cells, while also inhibiting metastasis in vivo. Through epigenetic reprogramming of snail, SETD1A induces epithelial-mesenchymal transition and metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Rui Wu, Wenbo Guo, Xinyao Qiu, Shicheng Wang, Chengjun Sui, Qiuyu Lian, Jianmin Wu, Yiran Shan, Zhao Yang, Shuai Yang, Tong Wu, Kaiting Wang, Yanjing Zhu, Shan Wang, Changyi Liu, Yangqianwen Zhang, Bo Zheng, Zhixuan Li, Yani Zhang, Siyun Shen, Yan Zhao, Wenwen Wang, Jinxia Bao, Ji Hu, Xuan Wu, Xiaoqing Jiang, Hongyang Wang, Jin Gu, Lei Chen
Summary: The study constructed a high-resolution spatial transcriptome map of primary liver cancers and revealed the evolution of tumor microenvironment characteristics from nontumor to tumor regions. It proposed a signature for accurately locating tertiary lymphoid structures spatially and identified interactions related to TME remodeling and tumor metastasis.
Review
Oncology
Ming Yang, Chunye Zhang
Summary: Liver sinusoidal endothelial cells (LSECs) play critical roles in liver physiology and pathology, with their altered state affecting the progression of liver diseases, including hepatocellular carcinoma. Targeting LSECs as a treatment strategy holds potential for preventing cancer liver metastasis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Shenyi Wang, Jinming Cai, Si Zhang, Mingwei Dong, Li Zhang, Yingying Xu, Bing Shen, She Chen
Summary: The study identified that decreased expression of Par3 is associated with aggressive phenotypes and poor prognosis in BLCA patients. Inhibition of GSK-3 beta promotes Snail expression and nuclear localization, leading to reduced Par3 expression and metastasis of BLCA cells. Additionally, an interaction between Par3 and ZO-1 was detected, which is involved in maintaining tight junctions in BLCA cells.
