Plasma Proteomics to Identify Drug Targets for Ischemic Heart Disease

Proteomic profiling identifies novel independent relationships between inflammatory proteins and myocardial infarction

(2023) Elsa Valdes-Marquez et al.   European Journal of Preventive Cardiology

Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility

(2023) Fengzhe Xu et al.   Nature Communications

CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T-cells

(2022) Guoshuai Feng et al.   CIRCULATION

Recent Developments in Clinical Plasma Proteomics—Applied to Cardiovascular Research

(2022) Nicolai Bjødstrup Palstrøm et al.   Biomedicines

CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure

(2022) Yang Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications

(2022) Maciej Tomaszewski et al.   KIDNEY INTERNATIONAL

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

(2022) Catherine Tcheandjieu et al.   NATURE MEDICINE

Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods

(2022) Daniel H. Katz et al.   Science Advances

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

(2022) Krishna G. Aragam et al.   NATURE GENETICS

Plasma proteins associated with cardiovascular death in patients with chronic coronary heart disease: A retrospective study

(2021) Lars Wallentin et al.   PLOS MEDICINE

Sortilin as a Biomarker for Cardiovascular Disease Revisited

(2021) Peter Loof Møller et al.   Frontiers in Cardiovascular Medicine

The association between plasma furin and cardiovascular events after acute myocardial infarction

(2021) Zhi-Wei Liu et al.   BMC Cardiovascular Disorders

Large-scale integration of the plasma proteome with genetics and disease

(2021) Egil Ferkingstad et al.   NATURE GENETICS

Pleiotropic Effects of the Protease-Activated Receptor 1 (PAR1) Inhibitor, Vorapaxar, on Atherosclerosis and Vascular Inflammation

(2021) Julian Friebel et al.   Cells

Temporal and spatial trends of ischemic heart disease burden in Chinese and subgroup populations from 1990 to 2016: socio-economical data from the 2016 global burden of disease study

(2020) Chenran Wang et al.   BMC Cardiovascular Disorders

Common gene variants in ASGR1 gene locus associate with reduced cardiovascular risk in absence of pleiotropic effects

(2020) Lubna Ali et al.   ATHEROSCLEROSIS

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

(2020) Kazuyoshi Ishigaki et al.   NATURE GENETICS

PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac Catheterization

(2020) Athan Kuliopulos et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Improved cardiovascular risk prediction using targeted plasma proteomics in primary prevention

(2020) Renate M Hoogeveen et al.   EUROPEAN HEART JOURNAL

Chemokines as Therapeutic Targets in Cardiovascular Disease

(2019) Heidi Noels et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations

(2019) Mihir A Kamat et al.   BIOINFORMATICS

Apolipoprotein B Particles and Cardiovascular Disease

(2019) Allan D. Sniderman et al.   JAMA Cardiology

Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: focus on lipid disorders

(2019) Marco Bruno Morelli et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval

(2019) Emily A. King et al.   PLoS Genetics

Assigning matrix metalloproteinase roles in ischaemic cardiac remodelling

(2018) Merry L. Lindsey   Nature Reviews Cardiology

Unexplored therapeutic opportunities in the human genome

(2018) Tudor I. Oprea et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci

(2018) Boxiang Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases

(2017) Claudia Goettsch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

VariantASGR1Associated with a Reduced Risk of Coronary Artery Disease

(2016) Paul Nioi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum chemokine CCL17/thymus activation and regulated chemokine is correlated with coronary artery diseases

(2015) Yicong Ye et al.   ATHEROSCLEROSIS

Sortilin, Encoded by the Cardiovascular Risk Gene SORT1, and Its Suggested Functions in Cardiovascular Disease

(2015) Mads Kjolby et al.   Current Atherosclerosis Reports

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes

(2015) Brendan M. Everett et al.   NEW ENGLAND JOURNAL OF MEDICINE

Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits

(2014) Joseph K. Pickrell   AMERICAN JOURNAL OF HUMAN GENETICS

Inflammatory markers in coronary heart disease

(2011) M. Madjid et al.   BRITISH MEDICAL BULLETIN

China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up

(2011) Z. Chen et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Multiplexed Homogeneous Proximity Ligation Assays for High-throughput Protein Biomarker Research in Serological Material

(2011) Martin Lundberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases

(2010) Tsuyoshi Kadomatsu et al.   FEBS Journal

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols