Review
Health Care Sciences & Services
Eleni Laou, Theodoros Mavridis, Nikolaos Papagiannakis, Gwendolyn Pais, Alberto Chighine, Jack Chang, Emanuela Locci, Ernesto D'Aloja, Marc Scheetz, Athanasios Chalkias, Theodoros Xanthos
Summary: This systematic review and meta-analysis investigated the role of blood biomarkers and metabolomic profiling in predicting VIKI. The results showed that blood biomarkers, including serum creatinine and blood urea nitrogen, can reflect the extent of kidney injury, but no novel blood biomarkers were explored.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Yanting Yu, Zhiyun Ren, Anni Xie, Yutao Jia, Ying Xue, Ping Wang, Daxi Ji, Xiaoyan Wang
Summary: The study confirmed that the urinary exosomal NHE3 protein increased in various types of acute kidney injury, serving as a potential diagnostic biomarker for AKI.
Article
Biochemistry & Molecular Biology
Marco Allinovi, Francesco Sessa, Gianluca Villa, Andrea Cocci, Samantha Innocenti, Maria Zanazzi, Lorenzo Tofani, Laura Paparella, Dritan Curi, Calogero Lino Cirami, Riccardo Campi, Andrea Mari, Agostino Ognibene, Maria Lorubbio, Alessandra Fanelli, Stefano Romagnoli, Paola Romagnani, Andrea Minervini
Summary: The study aimed to identify and compare serum and urinary predictors for predicting long-term decline in glomerular filtration rate (GFR) after robotic Nephron-Spearing Surgery (rNSS). The results showed that patients who developed clinical acute kidney injury (AKI) had a more pronounced decline in eGFR at 24 months. KineticGFR at 4 hours and NephroCheck at 10 hours were found to be efficient predictors of post-operative AKI and long-term eGFR decline. Combining these biomarkers could help identify high-risk patients as early as 10 hours after surgery.
Review
Critical Care Medicine
Ruilian You, Hua Zheng, Lubin Xu, Tiantian Ma, Gang Chen, Peng Xia, Xiaohong Fan, Peili Ji, Li Wang, Limeng Chen
Summary: The meta-analysis showed a significant negative association between uUMOD and AKI, especially in children and patients undergoing surgery. Lower uromodulin levels were associated with higher odds of AKI incidence, and age was found to be associated with the SMD of uUMOD in the meta-regression analysis. Sensitivity analysis confirmed the reliability of the study outcome.
JOURNAL OF INTENSIVE CARE
(2021)
Article
Biochemistry & Molecular Biology
Sandra M. Sancho-Martinez, Alfredo G. Casanova, Annette G. Duwel, Karen Rivero-Garcia, Tamara Garcia-Garrido, Ana I. Morales, Carlos Martinez-Salgado, Francisco J. Lopez-Hernandez, Pilar Fraile
Summary: Acute kidney injury (AKI) is a sudden renal dysfunction syndrome with severe consequences, and its etiology plays a role in the prognosis. Differentiating between pre-renal and intrinsic AKI is challenging using international diagnostic criteria, so additional biochemical criteria and patient history are necessary. A composite biochemical criterion, based on the congruency of at least two ratios, is proposed to minimize confounding factors. Urinary injury biomarkers, such as NGAL and KIM-1, better coincide with the biochemical classification and support an etiological diagnosis based on objective parameters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Transplantation
Stephen Duff, Ruairi Irwin, Jean Maxime Cote, Lynn Redahan, Blaithin A. McMahon, Brian Marsh, Alistair Nichol, Sinead Holden, Peter Doran, Patrick T. Murray
Summary: This study evaluated 14 urinary biomarkers and found that cystatin C, IL-18, albumin, and NGAL were the best predictors of AKI progression. These biomarkers may be useful for diagnostic and prognostic assessment of AKI.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Biao Qi, Yanyu Zhang, Bing Xu, Yuhao Zhang, Guoqiang Fei, Ling Lin, Qiuping Li
Summary: Acute ischemic stroke is a condition where one of the brain's main arteries is suddenly blocked, leading to insufficient oxygen and nutrients for brain cells. In this study, the metabolic changes in the biofluids of AIS patients were analyzed, revealing 29 significantly altered metabolites. The results showed a clear distinction between AIS patients and healthy controls, providing a sensitive and feasible diagnostic prospect for AIS patients.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Oncology
Sumit Sahni, Advait R. Pandya, William J. Hadden, Christopher B. Nahm, Sarah Maloney, Victoria Cook, James A. Toft, Lorna Wilkinson-White, Anthony J. Gill, Jaswinder S. Samra, Anthony Dona, Anubhav Mittal
Summary: The study identified a six-metabolite panel from urine samples with high potential for detecting and diagnosing pancreatic ductal adenocarcinoma (PDAC). This panel also showed strong potential for early detection of PDAC, paving the way for the development of a urine-based detection method in the future.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Urology & Nephrology
David S. Gardner, Jennifer C. Allen, Deborah Goodson, Daniel Harvey, Andrew Sharman, Henry Skinner, Adam Szafranek, John S. Young, Elizabeth H. Bailey, Mark A. J. Devonald
Summary: Urinary cadmium, copper, and zinc are novel biomarkers for early detection of acute kidney injury. Urinary trace metals have advantages over proteins as they are stable and can be tested economically using electrochemistry.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Multidisciplinary Sciences
Fantian Zeng, Sureya Nijiati, Yangtengyu Liu, Qinqin Yang, Xiaomin Liu, Qianyu Zhang, Shi Chen, Anqi Su, Hehe Xiong, Changrong Shi, Congbo Cai, Zhongning Lin, Xiaoyuan Chen, Zijian Zhou
Summary: An artemisinin-based probe (Art-Gd) was developed for contrast-enhanced magnetic resonance imaging of ferroptosis (feMRI) in anticancer drug-induced acute cardiac/kidney injuries (ACI/AKI). The probe showed great feasibility in early diagnosis of ACI/AKI, providing imaging evidence for the different mechanisms of action of ferroptosis-targeted agents. This study presents a feMRI strategy with simple chemistry and robust efficacy for early evaluation of anticancer drug-induced ACI/AKI.
Article
Biochemistry & Molecular Biology
Jakub Udzik, Aleksandra Waszczyk, Iwona Wojciechowska-Koszko, Pawel Kwiatkowski, Paulina Roszkowska, Karolina Rogulska, Krzysztof Safranow, Andrzej Biskupski, Sebastian Kwiatkowski, Ewa Kwiatkowska
Summary: This study indicates that plasma IL-8, plasma TNF-alpha, and urine NGAL/Cr show significant differences in postoperative biomarker concentrations between the AKI and no-AKI groups, serving as independent predictors of CSA-AKI. CKD is identified as an independent risk factor for CSA-AKI. Plasma IL-8, TNF-alpha, and urine NGAL/Cr are independent early indicators of CSA-AKI and offer a promising alternative to creatinine measurements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anesthesiology
Martin H. Bernardi, Ludwig Wagner, Sylvia Ryz, Juergen Puchinger, Larissa Nixdorf, Maximilian Edlinger-Stanger, Johannes Geilen, Matthias Kainz, Michael J. Hiesmayr, Andrea Lassnigg
Summary: The study suggests that urinary neprilysin may serve as a biomarker for the early detection of AKI after cardiac surgery, with high discriminatory power.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2021)
Article
Physiology
Eden A. Houske, Matthew G. Glimm, Annika R. Bergstrom, Sally K. Slipher, Hope D. Welhaven, Mark C. Greenwood, Greta M. Linse, Ronald K. June, Alan S. L. Yu, Darren P. Wallace, Alyssa K. Hahn
Summary: This study analyzed the urine metabolites of early-stage ADPKD patients and identified metabolic pathway alterations and candidate diagnostic and prognostic biomarkers. The results provide potential therapeutic targets and biomarkers for early diagnosis and tracking disease progression of ADPKD.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Durval Sampaio de Souza Garms, Karina Zanchetta Cardoso Eid, Emmanuel A. Burdmann, Lia Junqueira Marcal, Leila Antonangelo, Adriano dos Santos, Daniela Ponce
Summary: Acute kidney injury (AKI) related to vancomycin is frequent in hospitalized patients, with age, plasmatic vancomycin concentrations, and urinary NGAL identified as predictors of AKI related to vancomycin use. Plasmatic vancomycin concentrations and urinary NGAL were predictors of AKI diagnosis within the next 5 days, while urinary biomarkers of cell cycle arrest TIMP-2 and IGFBP-7, along with the duration of vancomycin use, were associated with non-recovery of kidney function at hospital discharge.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gustavo Casas-Aparicio, Claudia de la Barrera, David Escamilla-Illescas, Isabel Leon-Rodriguez, Perla Mariana Del Rio-Estrada, Natalia Calderon-Davila, Mauricio Gonzalez-Navarro, Rossana Olmedo-Ocampo, Manuel Castillejos-Lopez, Liliana Figueroa-Hernandez, Amy Peralta-Prado, Yara Luna-Villalobos, Elvira Piten-Isidro, Paola Fernandez-Campos, Santiago avila-Rios
Summary: A significant number of critically ill patients with COVID-19 develop acute kidney injury (AKI) and have high mortality rates. Early detection of subclinical AKI is crucial for AKI prevention. This study aimed to explore the urinary biomarkers NGAL and [TIMP-2] x [IGFBP7] for the early detection of AKI in COVID-19 patients. The results showed that combining [TIMP-2] x [IGFBP7] with clinical information was useful for identifying subclinical AKI in critically ill COVID-19 patients. Male gender and [TIMP-2] x [IGFBP7] >= 0.2 (ng/mL)(2)/1000 were identified as risk factors for AKI.