Long-term dynamics of multisite phosphorylation

Functional redundancy of the kinases MEK1 and MEK2: Rescue of theMek1mutant phenotype byMek2knock-in reveals a protein threshold effect

(2016) Rifdat Aoidi et al.   Science Signaling

Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling

(2016) Yuki Shindo et al.   Nature Communications

Functional redundancy of the kinases MEK1 and MEK2: Rescue of theMek1mutant phenotype byMek2knock-in reveals a protein threshold effect

(2016) Rifdat Aoidi et al.   Science Signaling

A Transport Model for Estimating the Time Course of ERK Activation in the C. elegans Germline

(2015) Henry H. Mattingly et al.   BIOPHYSICAL JOURNAL

Dynamics of Inductive ERK Signaling in the Drosophila Embryo

(2015) Bomyi Lim et al.   CURRENT BIOLOGY

RASopathies: unraveling mechanisms with animal models

(2015) G. A. Jindal et al.   Disease Models & Mechanisms

Mixed mechanisms of multi-site phosphorylation

(2015) T. Suwanmajo et al.   Journal of the Royal Society Interface

A proof of bistability for the dual futile cycle

(2015) Juliette Hell et al.   NONLINEAR ANALYSIS-REAL WORLD APPLICATIONS

Influence of diffusion on the kinetics of multisite phosphorylation

(2015) Irina V. Gopich et al.   PROTEIN SCIENCE

Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development

(2015) Christophe Frémin et al.   Cell Reports

MAP Kinase Modules: The Excursion Model and the Steps that Count

(2014) Alexander T. Piala et al.   BIOPHYSICAL JOURNAL

Paradoxical Results in Perturbation-Based Signaling Network Reconstruction

(2014) Sudhakaran Prabakaran et al.   BIOPHYSICAL JOURNAL

A Global Convergence Result for Processive Multisite Phosphorylation Systems

(2014) Carsten Conradi et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells

(2014) I. Michailovici et al.   DEVELOPMENT

Catalytic constants enable the emergence of bistability in dual phosphorylation

(2014) C. Conradi et al.   Journal of the Royal Society Interface

Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback

(2014) James E. Ferrell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cellular Compartments Cause Multistability and Allow Cells to Process More Information

(2013) Heather A. Harrington et al.   BIOPHYSICAL JOURNAL

ERK as a Model for Systems Biology of Enzyme Kinetics in Cells

(2013) Alan S. Futran et al.   CURRENT BIOLOGY

Precisely Ordered Phosphorylation Reactions in the p38 Mitogen-activated Protein (MAP) Kinase Cascade

(2013) John M. Humphreys et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diffusion modifies the connectivity of kinetic schemes for multisite binding and catalysis

(2013) I. V. Gopich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Quantitative Model of ERK MAP Kinase Phosphorylation in Crowded Media

(2013) Kazuhiro Aoki et al.   Scientific Reports

Molecular mechanisms creating bistable switches at cell cycle transitions

(2013) A. Verdugo et al.   Open Biology

Cellular ERK Phospho-Form Profiles with Conserved Preference for a Switch-Like Pattern

(2012) Bettina Hahn et al.   JOURNAL OF PROTEOME RESEARCH

Parameter-free model discrimination criterion based on steady-state coplanarity

(2012) H. A. Harrington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Design Principle for a Posttranslational Biochemical Oscillator

(2012) Craig C. Jolley et al.   Cell Reports

Substrate-Dependent Control of ERK Phosphorylation Can Lead to Oscillations

(2011) Ping Liu et al.   BIOPHYSICAL JOURNAL

Substrate-dependent control of MAPK phosphorylation in vivo

(2011) Y. Kim et al.   Molecular Systems Biology

Processive phosphorylation of ERK MAP kinase in mammalian cells

(2011) K. Aoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatio-temporal correlations can drastically change the response of a MAPK pathway

(2010) K. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Timing control in regulatory networks by multisite protein modifications

(2010) Carlos Salazar et al.   TRENDS IN CELL BIOLOGY

Multisite protein phosphorylation - from molecular mechanisms to kinetic models

(2009) Carlos Salazar et al.   FEBS Journal

Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors

(2009) C. Anastasaki et al.   HUMAN MOLECULAR GENETICS

Unlimited multistability in multisite phosphorylation systems

(2009) Matthew Thomson et al.   NATURE

Bistability by multiple phosphorylation of regulatory proteins

(2009) Orsolya Kapuy et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The Geometry of Multisite Phosphorylation

(2008) Arjun Kumar Manrai et al.   BIOPHYSICAL JOURNAL

Spatiotemporal Regulation of ERK2 by Dual Specificity Phosphatases

(2008) Christopher J. Caunt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY