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Gastroenterology & Hepatology
Chin Wong, Ajit Dash, Jill Fredrickson, Nicholas Lewin-Koh, Shan Chen, Kenta Yoshida, Yanqiu Liu, Johnny Gutierrez, Rebecca Kunder
Summary: BFKB8488A is well tolerated in patients with T2DM or NAFLD and has beneficial effects on triglyceride, HDL, and markers of liver health for both populations, with marked reduction in liver fat for patients with NAFLD.
Article
Biochemistry & Molecular Biology
Lea Sani, Nicolas Cardinault, Julien Astier, Patrice Darmon, Jean Francois Landrier
Summary: This study aimed to evaluate the effect of supplementation with standardized poplar propolis extract powder (PPEP) on insulin homeostasis in non-diabetic insulin-resistant volunteers with obesity. The results showed that PPEP supplementation improved insulin sensitivity by reducing the number of insulin-resistant subjects and decreasing the insulin sensitivity Matsuda index (ISI-M).
Article
Multidisciplinary Sciences
Franklyn Nonso Iheagwam, Olawumi Toyin Iheagwam, Michael Kemjika Onuoha, Olubanke Olujoke Ogunlana, Shalom Nwodo Chinedu
Summary: This study assessed the antidiabetic mechanism of Terminalia catappa aqueous leaf extract (TCA) in high fat/low dose streptozotocin-induced type 2 diabetic rats. The results showed that TCA exerts its antidiabetic action by reversing insulin resistance, improving glucose transport and activating PI3K/AKT signalling.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Takaaki Inaba, Mayumi Ohnishi-Kameyama, Ying Liu, Yasuhisa Tanaka, Masuko Kobori, Shusaku Tamaki, Tomotaka Ito, Kazunari Higa, Jun Shimazaki, Kazuo Tsubota
Summary: This study demonstrates that quercetin improves tear function through its effects on the lacrimal gland in mice and humans, and shows antioxidant activity that may serve as a preventive factor against aging and lifestyle diseases.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Dimeng Yang, Huey Lee Lew, Ying Yuan Mak, Sean Jun Leong Ou, Jie Ai Lim, Yuyun Lu, Cassandra Li Yi Seah, Magdalene Qiao Hui Tan, Dejian Huang, E. Shyong Tai, Mei Hui Liu
Summary: This study investigated the use of freeze-dried okra seed flour (OSF) as a functional ingredient to lower the glycemic index (GI) of rice noodles and attenuate postprandial blood glucose rise. The results showed that 20% okra seed fortified noodles significantly reduced postprandial glucose and insulin peaks compared to the control noodles. The addition of OSF also increased satiety and did not affect gut hormone responses.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Oncology
Adnan Deronic, Anneli Nilsson, Mia Thagesson, Doreen Werchau, Karin Enell Smith, Peter Ellmark
Summary: Mitazalimab, a human anti-CD40 agonist antibody, was found to activate antigen-presenting cells, leading to expansion and activation of antigen-specific T cells, ultimately enhancing the anti-tumor efficacy of a model cancer vaccine.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)