Review
Biochemistry & Molecular Biology
Stephanie M. Kereliuk, Vernon W. Dolinsky
Summary: Globally, cardiovascular disease remains the leading cause of death, and the increasing cardiovascular risk factors among youth, such as obesity, diabetes, and hypertension, contribute to the development of earlier and more severe cardiovascular disease. Recent evidence suggests that maternal obesity and diabetes during pregnancy have lifelong effects on cardiovascular risk factors and heart disease development in the offspring, although the mechanisms for these observations are unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Long T. Nguyen, Carol A. Pollock, Sonia Saad
Summary: The developmental programming hypothesis suggests that adverse environmental insults during critical developmental periods increase the risk of diseases in later life. Kidneys are susceptible to such insults, particularly due to peri-gestational nutrition, which affects kidney development and metabolism. Recent studies have identified oxidative stress, mitochondrial dysfunction, epigenetic modifications, and metabolic changes as potential novel pathways for therapeutic intervention.
Article
Neurosciences
Megan G. McGill, Irina Pokhvisneva, Andrew S. Clappison, Lisa M. McEwen, Roseriet Beijers, Marieke S. Tollenaar, Hung Pham, Michelle Z. L. Kee, Elika Garg, Euclides J. de Mendonca Filho, Neerja Karnani, Patricia P. Silveira, Michael S. Kobor, Carolina de Weerth, Michael J. Meaney, Kieran J. O'Donnell
Summary: Prenatal maternal anxiety predicts child PedBE epigenetic age acceleration, predominantly in males. PedBE age acceleration predicts increased externalizing symptoms in males in the BIBO cohort.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Obstetrics & Gynecology
Brian J. Koos, Jeffrey A. Gornbein
Summary: This metabolomics study identified a high-accuracy model for predicting gestational diabetes mellitus in early pregnancy. The research showed that certain metabolites were independently associated with gestational diabetes mellitus and could be used as predictive markers. This finding contributes to future studies on early therapeutic interventions for gestational diabetes mellitus.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marina Horvaticek, Maja Peric, Ivona Beceheli, Marija Klasic, Maja Zutic, Maja Kesic, Gernot Desoye, Sandra Nakic Rados, Marina Ivanisevic, Dubravka Hranilovic, Jasminka Stefulj
Summary: This study demonstrates that maternal metabolic status affects the methylation level of HTR2A in the placenta. Maternal obesity and gestational diabetes mellitus are associated with reduced HTR2A promoter methylation in female placentas, while tobacco use during pregnancy is associated with reduced HTR2A promoter methylation in male placentas. These findings contribute to a better understanding of the early developmental origins of neurobehavioral and metabolic disorders associated with altered HTR2A function.
Article
Biology
Suhas Sureshchandra, Brianna M. Doratt, Norma Mendza, Oleg Varlamov, Monica Rincon, Nicole E. Marshall, Ilhem Messaoudi
Summary: Maternal pre-pregnancy obesity is linked to unfavorable outcomes in both mother and offspring, including increased susceptibility and severity of neonatal infections. This study reveals that pregravid obesity disrupts umbilical cord blood monocyte responses to bacterial and viral pathogens. It demonstrates that interferon-stimulated gene expression and inflammatory responses to respiratory syncytial virus and E. coli are significantly dampened. Additionally, it suggests that maternal obesity alters metabolic, signaling, and epigenetic profiles of fetal monocytes, leading to immune paralysis during late gestation and at birth.
Review
Nutrition & Dietetics
Sanjay Basak, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy
Summary: Obesity in pregnancy has various effects on fetal neurodevelopment, such as disturbing the transport of essential long-chain PUFAs for brain development and altering the maternal gut microbiota, which further affects fetal brain development.
Article
Multidisciplinary Sciences
Takao Takiyama, Toshihiro Sera, Masanori Nakamura, Masato Hoshino, Kentaro Uesugi, Shin-ichi Horike, Makiko Meguro-Horike, Ryoichi Bessho, Yuri Takiyama, Hiroya Kitsunai, Yasutaka Takeda, Kazuki Sawamoto, Naoto Yagi, Yuji Nishikawa, Yumi Takiyama
Summary: Maternal overnutrition affects offspring susceptibility to nonalcoholic steatohepatitis (NASH), potentially through inducing fetal liver hypoxia, leading to the development of NASH/hepatocellular carcinoma (HCC) in offspring. HORMAD1 may be a potential therapeutic target for NASH/HCC.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Bruna de Souza Lima, Ana Paula Varela Sanches, Maira Schuchter Ferreira, Josilene Lopes de Oliveira, Jane K. Cleal, Leticia Ignacio-Souza
Summary: Maternal obesity can have an impact on the health of offspring, particularly during critical periods. Studies have shown that diet and nutritional status play a crucial role in fetal outcomes and placental development. Specifically, a high-fat diet can be considered as a nutritional insult that impairs the maternal-placental axis, thus affecting offspring development and outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Pharmacology & Pharmacy
Hana Horackova, Rona Karahoda, Lukas Cerveny, Veronika Vachalova, Ronja Ebner, Cilia Abad, Frantisek Staud
Summary: Depression is common during pregnancy and many women are prescribed antidepressants. These drugs may disrupt serotonin homeostasis in the placenta or fetus, potentially leading to adverse effects of antidepressant use during pregnancy.
Review
Developmental Biology
Avery C. Kramer, Thomas Jansson, Tracy L. Bale, Theresa L. Powell
Summary: Altered placental function may mediate the link between the maternal environment and fetal growth and development, through nutrient sensing, modulation of transporters, and changes in extracellular vesicles. Maternal diet and stress can also influence fetal development and metabolism, and fetal growth restriction may increase the risk of chronic disease later in life.
Article
Medicine, General & Internal
Jerod M. Rasmussen, Jetro J. Tuulari, Saara Nolvi, Paul M. Thompson, Harri Merisaari, Maria Lavonius, Linnea Karlsson, Sonja Entringer, Pathik D. Wadhwa, Hasse Karlsson, Claudia Buss
Summary: Using an international dataset, researchers found a link between maternal overweight/obesity during pregnancy and the development of fetal hypothalamus in newborns. These findings can contribute to future prevention strategies for childhood obesity.
Review
Endocrinology & Metabolism
Hiroaki Itoh, Megumi Ueda, Misako Suzuki, Yukiko Kohmura-Kobayashi
Summary: Metabolic syndrome, associated with obesity, increases the risk of type 2 diabetes, coronary diseases, stroke, and other disabilities. The Developmental Origins of Health and Disease (DOHaD) theory suggests that early developmental environmental imbalance affects health and predisposes individuals to non-communicable diseases, including metabolic syndrome. The 'Thrifty Phenotype' hypothesis proposes that undernourished fetuses develop evolutionary advantageous traits for survival in a hangry environment after birth, but this phenotype increases the risk of metabolic syndrome under an obesogenic diet. Chronic inflammation, referred to as 'Metaflammation', is believed to mediate the connection between obesity and metabolic disorders in metabolic syndrome. However, the contribution of evolutionary maladaptation to the pathophysiology of 'Metaflammation' remains understudied. Investigating 'Metaflammation' from the perspective of selective advantages and mismatches to contemporary lifestyles can provide valuable insights, considering the concept of evolutionarily conserved nutrient sensing and immune signaling systems.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biology
Laura Dearden, Susan E. Ozanne
Summary: The number of pregnancies complicated by obesity is increasing, with over 50% of pregnancies in developed countries occurring in overweight or obese women. Maternal obesity is linked to adverse outcomes for both mother and baby during pregnancy, as well as an increased risk of cardio-metabolic disease in offspring later in life. Research suggests that the impact of maternal obesity on fetal development goes beyond genetic and lifestyle factors, highlighting the importance of the intrauterine environment. This article discusses the long-term consequences of maternal obesity on offspring health, potential molecular mechanisms, and interventions during pregnancy.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Maria de la Calle, Jose L. Bartha, Clara Marin, Juan Carlos Rus, Guillermo Corcoles, Santiago Ruvira, David Ramiro-Cortijo
Summary: There is an increasing number of obese mothers having twin pregnancies, and proper gestational weight control is crucial for mothers with high pre-gestational BMI.
Article
Public, Environmental & Occupational Health
A. Bansal, C. Li, F. Xin, A. Duemler, W. Li, C. Rashid, M. S. Bartolomei, R. A. Simmons
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2019)
Correction
Public, Environmental & Occupational Health
A. Bansal, C. Li, F. Xin, A. Duemler, W. Li, C. Rashid, M. S. Bartolomei, R. A. Simmons
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2019)
Article
Endocrinology & Metabolism
Jeffrey D. Roizen, Caela Long, Alex Casella, Lauren O'Lear, Ilana Caplan, Meizan Lai, Issac Sasson, Ravinder Singh, Andrew J. Makowski, Rebecca Simmons, Michael A. Levine
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Nutrition & Dietetics
Yu-Chin Lien, David E. Condon, Michael K. Georgie, Rebecca A. Simmons, Phu V. Tran
Article
Pediatrics
Mark W. Russell, Julie S. Moldenhauer, Jack Rychik, Nancy B. Burnham, Erin Zullo, Samuel Parry, Rebecca A. Simmons, Michal A. Elovitz, Susan C. Nicolson, Rebecca L. Linn, Mark P. Johnson, Sunkyung Yu, Matthew G. Sampson, Hakon Hakonarson, J. William Gaynor
JOURNAL OF PEDIATRICS
(2019)
Editorial Material
Public, Environmental & Occupational Health
Rebecca Simmons
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Summer Elshenawy, Sara E. Pinney, Tami Stuart, Paschalis-Thomas Doulias, Gabriella Zura, Samuel Parry, Michal A. Elovitz, Michael J. Bennett, Amita Bansal, Jerome F. Strauss, Harry Ischiropoulos, Rebecca A. Simmons
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Clinical Neurology
Allison E. Zanno, Micah A. Romer, Lauren Fox, Thea Golden, Lane Jaeckle-Santos, Rebecca A. Simmons, Judith B. Grinspan
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2019)
Article
Endocrinology & Metabolism
Yu-Chin Lien, Kyoung-Jae Won, Rebecca A. Simmons
Editorial Material
Public, Environmental & Occupational Health
Tessa J. Roseboom, Susan E. Ozanne, Keith M. Godfrey, Carmen R. Isasi, Hiroaki Itoh, Rebecca Simmons, Amita Bansal, Mary Barker, Torsten Plosch, Deb M. Sloboda, Stephen G. Matthews, Caroline H. D. Fall, Lucilla Poston, Mark A. Hanson
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Article
Neurosciences
Shazia F. Bhat, Sara E. Pinney, Katherine M. Kennedy, Cole R. McCourt, Miles A. Mundy, Michael G. Surette, Deborah M. Sloboda, Rebecca A. Simmons
Summary: The study revealed that high fructose corn syrup (HFCS) consumption during adolescence can lead to obesity, hepatic fat accumulation, impaired glucose tolerance, and other metabolic abnormalities, which can persist into adulthood and affect the gut microbiome in a sex-specific manner.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Endocrinology & Metabolism
Tammy Ying, Thea Golden, Lan Cheng, Jeff Ishibashi, Patrick Seale, Rebecca A. Simmons
Summary: The study revealed that exposure to IL-4 during the neonatal period induces acute beige adipogenesis while reducing adipogenic differentiation capacity long term. Adult adipocyte precursors also show persistently decreased adipogenesis without increased browning after neonatal IL-4 treatment, indicating long-lasting effects of IL-4.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Yu-Chin Lien, Sara E. Pinney, Xueqing Maggie Lu, Rebecca A. Simmons
Summary: Intrauterine growth restriction (IUGR) leads to the development of type 2 diabetes in adulthood through permanent alterations in gene expression, which involve an epigenetic mechanism. Using a rat model of IUGR, this study investigated the association between DNA methylation changes and gene dysregulation in islets. The findings revealed critical pathways for islet function and identified potential transcription factors and genes that are involved in the development of IUGR. Additionally, the integration of methylome and transcriptome data sets provided further insights into the regulatory regions of the genome altered by IUGR. Overall, these findings suggest that epigenetic changes at key transcription factor binding motifs and other gene regulatory regions may contribute to gene dysregulation and abnormal islet phenotype in IUGR rats.
Editorial Material
Neurosciences
Rebecca Simmons
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Multidisciplinary Sciences
Mark W. Russell, Julie S. Moldenhauer, Jack Rychik, Nancy B. Burnham, Erin Zullo, Samuel I. Parry, Rebecca A. Simmons, Michal A. Elovitz, Susan C. Nicolson, Rebecca L. Linn, Mark P. Johnson, Sunkyung Yu, Matthew G. Sampson, Hakon Hakonarson, J. William Gaynor
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
