Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 422, Issue C, Pages 192-202Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2015.12.004
Keywords
alpha 7nAChR; Cholinergic anti-inflammatory pathway; LPS; Maternal imprinting; Obese mice; High-fat diet
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Funding
- Sao Paulo Research Foundation (FAPESP) [14/18165-9, 13/10706-8]
- CNPq [476643/2012-0]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [13/10706-8] Funding Source: FAPESP
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Cholinergic anti-inflammatory pathway (CAP) prevents inflammatory cytokines production. The main was to evaluate the effect of maternal obesity on cholinergic pathway in the offspring. Female mice were subjected to either standard chow (SC) or high-fat diet (HFD) during pregnancy and the lactation period. After weaning, only male offspring from HFD dams (HFD-O) and from SC dams (SC-O) were fed the SC diet. Key proteins of the CAP were downregulated and serum TNF-alpha was elevated in the HFD-O mice. STAT3 and NF-kappa B activation in HFD-O mice ICV injected with nicotine (agonist) were lower than SC-O mice. Basal cholinesterase activity was upregulated in HFD-O mice in both investigated tissues. Lipopolysaccharide increased TNF-alpha and IL-1 beta expression in the liver and WAT of SC-O mice, but this effect was greater in HFD-O mice. In conclusion these changes exacerbated cytokine production in response to LPS and contributed to the reduced sensitivity of the CAP. (C) 2015 Published by Elsevier Ireland Ltd.
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