Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 432, Issue C, Pages 47-53Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2015.07.019
Keywords
Mesenchymal cells; Estrogen-Related Receptors; Bone cells; Bone loss
Categories
Funding
- Ligue contre le Cancer (comites Drome et Puy de Dome)
- Association pour la Recherche sur le Cancer (ARC)
- Agence Nationale pour la Recherche [ANR-14-CE12-0003-03]
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Bone loss is naturally occurring in aging males and females and exacerbated in the latter after menopause, altogether leading to cumulative skeleton fragility and increased fracture risk. Two types of therapeutic strategies can be envisioned to counteract age- or menopause-associated bone loss, aiming at either reducing bone resorption exerted by osteoclasts or, alternatively, promoting bone formation by osteoblasts. We here summarize data suggesting that inhibition of the Estrogen-Related Receptors alpha and/or gamma could promote bone formation and compensate for bone loss induced by ageing or estrogen deficiency. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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