Orexin-A promotes Glu uptake by OX1R/PKCα/ERK1/2/GLT-1 pathway in astrocytes and protects co-cultured astrocytes and neurons against apoptosis in anoxia/hypoglycemic injury in vitro

OS 02-07 WNT5A/ROR2 SUPPRESSES THE PROLIFERATION OF SMOOTH MUSCLE CELL VIA PKC SIGNALING PATHWAY

(2016) Li Qin et al.   JOURNAL OF HYPERTENSION

Excitatory amino acid transporters tonically restrain nTS synaptic and neuronal activity to modulate cardiorespiratory function

(2016) Michael P. Matott et al.   JOURNAL OF NEUROPHYSIOLOGY

Allium cepaExtract and Quercetin Protect Neuronal Cells from Oxidative Stress via PKC-εInactivation/ERK1/2 Activation

(2016) Bo Kyung Lee et al.   Oxidative Medicine and Cellular Longevity

THC (Δ9-Tetrahydrocannabinol) Exerts Neuroprotective Effect in Glutamate-affected Murine Primary Mesencephalic Cultures Through Restoring Mitochondrial Membrane Potential and Anti-apoptosis Involving CB1Receptor-dependent Mechanism

(2016) Chi Huu Nguyen et al.   PHYTOTHERAPY RESEARCH

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

(2015) Marian Valko et al.   ARCHIVES OF TOXICOLOGY

Astrocytic glutamate uptake is slow and does not limit neuronal NMDA receptor activation in the neonatal neocortex

(2015) Elizabeth Hanson et al.   GLIA

Orexin Signaling in the VTA Gates Morphine-Induced Synaptic Plasticity

(2015) C. Baimel et al.   JOURNAL OF NEUROSCIENCE

Evaluation of sperm DNA damage in bulls by TUNEL assay as a parameter of semen quality

(2015) Kumiko TAKEDA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Changes in orexin (hypocretin) neuronal expression with normal aging in the human hypothalamus

(2015) Nicholas J. Hunt et al.   NEUROBIOLOGY OF AGING

Orexin-A differentially modulates AMPA-preferring responses of ganglion cells and amacrine cells in rat retina

(2015) Chao Zheng et al.   NEUROPHARMACOLOGY

Effects of activation and blockade of orexin A receptors in the medial preoptic area on food intake in male rats

(2015) Abdolrahman Sarihi et al.   NEUROSCIENCE LETTERS

Orexin-A modulates excitatory synaptic transmission and neuronal excitability in the spinal cord substantia gelatinosa

(2015) Younghoon Jeon et al.   NEUROSCIENCE LETTERS

Circulating Levels of Orexin-A, Nesfatin-1, Agouti-Related Peptide, and Neuropeptide Y in Patients with Hyperthyroidism

(2015) Yusuf Tohma et al.   THYROID

Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons

(2014) Mazher Mohammed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Gastrodin Inhibits Glutamate-Induced Apoptosis of PC12 Cells via Inhibition of CaMKII/ASK-1/p38 MAPK/p53 Signaling Cascade

(2014) Genling Jiang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cerebrospinal-fluid orexin levels and daytime somnolence in frontotemporal dementia

(2014) C. Liguori et al.   JOURNAL OF NEUROLOGY

Motivational activation: a unifying hypothesis of orexin/hypocretin function

(2014) Stephen V Mahler et al.   NATURE NEUROSCIENCE

Effects of catalpol on ATPase and amino acids in gerbils with cerebral ischemia/reperfusion injury

(2014) Yan-ru Liu et al.   NEUROLOGICAL SCIENCES

Pre-ischemic treadmill training alleviates brain damage via GLT-1-mediated signal pathway after ischemic stroke in rats

(2014) X. Wang et al.   NEUROSCIENCE

Neuroprotection by Orexin-A via HIF-1α induction in a cellular model of Parkinson's disease

(2014) Ya Feng et al.   NEUROSCIENCE LETTERS

Orexin-A Promotes Cell Migration in Cultured Rat Astrocytes via Ca2+-Dependent PKCα and ERK1/2 Signals

(2014) Qing Shu et al.   PLoS One

Role of Orexin-A-mediated Communication System between Brain and Peripheral Tissues on the Development of Post-ischemic Glucose Intolerance-induced Neuronal Damage

(2014) Shinichi Harada   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

δ-Opioid Receptors and Inflammatory Cytokines in Hypoxia: Differential Regulation Between Glial and Neuron-Like Cells

(2014) Qinyu Wang et al.   Translational Stroke Research

Orexin receptors: Multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders

(2013) Tian-Rui Xu et al.   CELLULAR SIGNALLING

Orexin (Hypocretin) Receptor Agonists and Antagonists for Treatment of Sleep Disorders

(2013) Michihiro Mieda et al.   CNS DRUGS

Proteome Analysis and Conditional Deletion of the EAAT2 Glutamate Transporter Provide Evidence against a Role of EAAT2 in Pancreatic Insulin Secretion in Mice

(2013) Yun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orexins Protect Neuronal Cell Cultures Against Hypoxic Stress: an Involvement of Akt Signaling

(2013) Paulina Sokołowska et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The octadecaneuropeptide ODN prevents 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons through a PKC-MAPK-dependent pathway

(2013) Hadhemi Kaddour et al.   JOURNAL OF NEUROCHEMISTRY

Orexin-A-induced ERK1/2 activation reverses impaired spatial learning and memory in pentylenetetrazol-kindled rats via OX1R-mediated hippocampal neurogenesis

(2013) Xuan Zhao et al.   PEPTIDES

Plasmalogens Rescue Neuronal Cell Death through an Activation of AKT and ERK Survival Signaling

(2013) Md. Shamim Hossain et al.   PLoS One

Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus

(2013) R. M. Sears et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitigation of Murine Focal Cerebral Ischemia by the Hypocretin/Orexin System is Associated With Reduced Inflammation

(2013) Xiaoxing Xiong et al.   STROKE

PKC signaling prevents irradiation-induced apoptosis of primary human fibroblasts

(2013) A Bluwstein et al.   Cell Death & Disease

Ginsenoside Rd promotes glutamate clearance by up-regulating glial glutamate transporter GLT-1 via PI3K/AKT and ERK1/2 pathways

(2013) Xiao Zhang   Frontiers in Pharmacology

The effect of levetiracetam on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury

(2012) Hasan Kilicdag et al.   EARLY HUMAN DEVELOPMENT

Apolipoprotein E protects astrocytes from hypoxia and glutamate-induced apoptosis

(2012) Shuai Zhou et al.   FEBS LETTERS

Hexane extract from Polygonum multiflorum attenuates glutamate-induced apoptosis in primary cultured cortical neurons

(2012) Ji Yeon Jang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Phenolic Alkaloids from Menispermum dauricum Rhizome Protect against Brain Ischemia Injury via Regulation of GLT-1, EAAC1 and ROS Generation

(2012) Bo Zhao et al.   MOLECULES

Examining the role of endogenous orexins in hypothalamus–pituitary–adrenal axis endocrine function using transient dual orexin receptor antagonism in the rat

(2012) Michel A. Steiner et al.   PSYCHONEUROENDOCRINOLOGY

Human Dental Pulp-Derived Stem Cells Protect Against Hypoxic-Ischemic Brain Injury in Neonatal Mice

(2012) Mari Yamagata et al.   STROKE

Targeted Over-Expression of Glutamate Transporter 1 (GLT-1) Reduces Ischemic Brain Injury in a Rat Model of Stroke

(2011) Brandon K. Harvey et al.   PLoS One

Dynamic Regulation of the Kv2.1 Voltage-Gated Potassium Channel during Brain Ischemia through Neuroglial Interaction

(2008) H. Misonou et al.   JOURNAL OF NEUROSCIENCE

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

(2003) J. David Sweatt   JOURNAL OF NEUROCHEMISTRY