Journal
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Volume 210, Issue 1-2, Pages 50-54Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbiopara.2016.08.005
Keywords
Leishmania braziliensis; Totiviridae; American cutaneous leishmaniasis
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Programa Pesquisador Mineiro VIII [FAPEMIG 00163-14]
- Universal/CNPq [480760/2013-6]
- NIH [AID R56 AI099364]
- [NIHR01-AI29646]
Ask authors/readers for more resources
The double stranded RNA (dsRNA) virus Leishmaniavirus (Totiviridae) was first described in Leishmania guyanensis and L braziliensis (LRV1), and more recently from L major and L aethiopica (LRV2). Parasites bearing LRV1 elicit a higher pro-inflammatory profile, arising through activation of Toll like receptor 3(TLR3) interacting with the viral dsRNA. LRV1 is most common in Leishmania from the Amazon region; however data for other regions of Brazil are more limited. Here we applied PCR tests with validated 'universal' LRV1 primers to search for LRV1 in 40 strains of cultured L. braziliensis from several locales within Minas Gerais State, including patients presenting with atypical lesion pathology. All strains were negative however. These data are in agreement with results from other areas of Southeastern Brazil that LRV1 is relatively uncommon. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available