Stable isotope synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites

Synthesis of (4-Trifluoromethyl)isoxazoles through a Tandem Trifluoromethyloximation/Cyclization/Elimination Reaction of α,β-Unsaturated Carbonyls

(2023) Paramita Pattanayak et al.   Journal of Organic Chemistry

Development of a Scalable Asymmetric Process for the Synthesis of GLYT1 Inhibitor BI 425809 (Iclepertin)

(2023) Rogelio Frutos et al.   Organic Process Research & Development

Carbon 14 synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites

(2023) Bachir Latli et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles

(2019) Bohdan A. Chalyk et al.   JOURNAL OF ORGANIC CHEMISTRY

Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation

(2018) Joshua D. Sieber et al.   JOURNAL OF ORGANIC CHEMISTRY

Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia

(2010) Emmanuel Pinard et al.   JOURNAL OF MEDICINAL CHEMISTRY