Article
Clinical Neurology
Terry E. Goldberg, Seonjoo Lee, Davangere P. Devanand, Lon S. Schneider
Summary: Using per cent slowing of decline as a metric of outcome in Alzheimer's disease clinical trials may be misleading, while Cohen's d is a more valid and informative measure of efficacy. Standardised effect size determines group overlap, influences NNT computations, and provides information on the likelihood of minimum clinically important differences.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Jochum J. Van 't Hooft, Wiesje Pelkmans, Jori Tomassen, Cas Smits, Nienke Legdeur, Anouk Den Braber, Frederik Barkhof, Bart Van Berckel, Maqsood Yaqub, Philip Scheltens, Yolande A. L. Pijnenburg, Pieter Jelle Visser, Betty M. Tijms
Summary: Hearing loss in older adults is associated with increased dementia risk, and the underlying mechanisms connecting the two remain unclear. This study found an association between hearing loss and biomarkers for dementia risk, and the association varied between different age groups. In older adults, hearing loss was associated with a decline in memory, global cognition, and language.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Sarah-Naomi James, Yu-Jie Chiou, Nasri Fatih, Louisa P. Needham, Jonathan M. Schott, Marcus Richards
Summary: This study found that being physically active at any time and to any extent in adulthood is associated with higher cognitive function in later life. Long-term maintenance of physical activity is particularly beneficial for cognitive state in old age. These associations are partly explained by childhood cognition and education, but are independent of cardiovascular and mental health and APOE-E4.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Zoe B. Mills, Richard L. M. Faull, Andrea Kwakowsky
Summary: Alzheimer's disease disproportionately affects women, with two thirds of all cases being female. The decline in estrogen levels during menopause is believed to be a contributing factor to the higher risk of developing AD in women. This review evaluates the impact of estrogen and hormone replacement therapy on cognition in women, and discusses the conflicting findings regarding the use of HRT as a preventive or therapeutic option for AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Min Young Chun, Hyemin Jang, Soo-Jong Kim, Yu Hyun Park, Jihwan Yun, Samuel N. Lockhart, Michael Weiner, Charles De Carli, Seung Hwan Moon, Jae Yong Choi, Kyung Rok Nam, Byung-Hyun Byun, Sang-Moo Lim, Jun Pyo Kim, Yeong Sim Choe, Young Ju Kim, Duk L. Na, Hee Jin Kim, Sang Won Seo
Summary: Alzheimer's disease (AD) is characterized by amyloid-beta accumulation, tau aggregation, and neurodegeneration. Vascular burden has synergistic effects on cognitive decline with AD biomarkers. The distribution and longitudinal outcomes of AT(N) categories differ according to vascular burden, emphasizing the importance of incorporating a vascular biomarker into the AT(N) system.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Clinical Neurology
Michael C. B. David, Martina Del Giovane, Kathy Y. Liu, Benjamin Gostick, James Benedict Rowe, Imafidon Oboh, Robert Howard, Paresh A. Malhotra
Summary: This study assessed the efficacy of drugs with noradrenergic action in improving cognitive and neuropsychiatric symptoms in Alzheimer's disease. The findings showed a small positive effect on global cognition and a large positive effect on apathy. This suggests that repurposing established noradrenergic drugs may offer effective treatment for certain symptoms in Alzheimer's disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Review
Genetics & Heredity
Desyrre Tedeschi, Anderson F. da Cunha, Marcia R. Cominetti, Renata Valle Pedroso
Summary: Research indicates that gene therapy has a positive impact on improving cognition in AD, but clinical studies have shown inconclusive results, with viral vector delivery methods being a key factor. Interpretation of the potential of gene therapy in treating AD should be approached with caution.
CURRENT GENE THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Khaled Hameed Husain, Saud Faisal Sarhan, Haya Khaled Ali Abdulla AlKhalifa, Asal Buhasan, Abu Saleh Md Moin, Alexandra E. Butler
Summary: Hypoglycemia, a common consequence of diabetes treatment, is associated with severe morbidity and mortality and has become a major barrier to intensifying antidiabetic therapy. Dementia generally refers to the loss of memory, language, problem-solving, and other cognitive functions, which can interfere with daily life, and there is growing evidence that diabetes is associated with an increased risk of both vascular and non-vascular dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Y. Mukish Yelanchezian, Henry J. Waldvogel, Richard L. M. Faull, Andrea Kwakowsky
Summary: This review summarizes the research on the effects of caffeine on Alzheimer's disease (AD) and cognition. Clinical studies suggest a neuroprotective effect of caffeine against dementia and possibly AD, but further research is needed for confirmation. Caffeine is considered a cognitive normalizer rather than an enhancer, and its neuroprotective effect may be influenced by gender. In vivo and in vitro studies provide robust evidence of caffeine's neuroprotective properties in AD animal models.
Article
Psychiatry
Stephen Z. Levine, Yair Goldberg, Kazufumi Yoshida, Myrto Samara, Andrea Cipriani, Takeshi Iwatsubo, Stefan Leucht, Toshiaki A. Furukawa
Summary: This study examined the association between early improvement and subsequent change in cognition in antidementia clinical trials. The results showed that early responders to antidementia medication had more significant improvement in cognition compared to non-early responders, which was supported by sensitivity analysis.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
S. Charisis, E. Ntanasi, M. Yannakoulia, C. A. Anastasiou, M. H. Kosmidis, E. Dardiotis, G. Hadjigeorgiou, P. Sakka, A. S. Veskoukis, D. Kouretas, N. Scarmeas
Summary: The study found that higher baseline plasma GSH levels were associated with a decreased risk of developing AD and with a better preservation of executive functioning longitudinally in non-demented older adults living in the community.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Ellen H. Singleton, Jay L. P. Fieldhouse, Jochum J. van 't Hooft, Marta Scarioni, Marie-Paule E. van Engelen, Sietske A. M. Sikkes, Casper de Boer, Diana Bocancea, Esther van den Berg, Philip Scheltens, Wiesje M. van der Flier, Janne M. Papma, Yolande A. L. Pijnenburg, Rik Ossenkoppele
Summary: The study examines the social cognition impairments in patients with behavioural variant of Alzheimer's disease (bvAD) and compares them with patients with behavioural variant frontotemporal dementia (bvFTD) and typical Alzheimer's disease. The findings suggest that patients with bvAD exhibit similar but milder social cognition impairments compared to bvFTD, and greater impairments compared to typical Alzheimer's disease.
Article
Clinical Neurology
Ping-Tao Tseng, Yen-Wen Chen, Bing-Yan Zeng, Bing-Syuan Zeng, Chao-Ming Hung, Cheuk-Kwan Sun, Yu-Shian Cheng, Brendon Stubbs, Andre F. F. Carvalho, Andre R. R. Brunoni, Kuan-Pin Su, Yu-Kang Tu, Yi-Cheng Wu, Tien-Yu Chen, Pao-Yen Lin, Chih-Sung Liang, Chih-Wei Hsu, Che-Sheng Chu, Mein-Woei Suen, Cheng-Ta Li
Summary: This network meta-analysis evaluated the efficacy and safety of noninvasive brain stimulation (NIBS) interventions in patients with Alzheimer's disease (AD). The combination of cathodal tDCS of the left dorsolateral prefrontal cortex and anodal tDCS over the right supraorbital region (c-tDCS-F3 + a-tDCS-Fp2) showed the most beneficial effect on cognition among all the investigated NIBS approaches. These findings provide evidence for the benefits of NIBS, particularly tDCS, in improving cognition in AD patients.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Maria Patricia A. Oliveira Monteiro, Danielle S. M. Salheb Oliveira, Patricia R. Manzine, Carla M. Crispim Nascimento, Ariene A. dos Santos Orlandi, Grace A. de Oliveira Gomes, Fabiana dos Santos Orlandi, Marisa S. Zazzetta, Henrique Pott-Junior, Marcia R. Cominetti
Summary: Blood-based biomarkers are urgently needed for Alzheimer's disease diagnosis in clinical practice. This study found that plasma ADAM10 levels were significantly associated with cognitive decline in older adults during a 3-year follow-up period. The results suggest that ADAM10 may serve as a potential predictor for cognitive worsening, contributing to the advancement of blood biomarkers for AD research.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Neurosciences
Jasmine Carcamo, Anton J. Kociolek, Kayri K. Fernandez, Yian Gu, Carolyn W. Zhu, Yaakov Stern, Stephanie Cosentino
Summary: This study assessed the predictive value of neuropsychological tests for severe dependency in Alzheimer's disease. Findings indicated that higher semantic processing and memory test scores at baseline were associated with lower risk of severe dependency. This suggests that the integrity of semantic processing and memory abilities in dementia can predict time to severe functional dependency.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Martha Sajatovic, Annemiek Dols, Soham Rej, Osvaldo P. Almeida, Alexandra J. M. Beunders, Hilary P. Blumberg, Farren B. S. Briggs, Brent P. Forester, Regan E. Patrick, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Eduard Vieta, Benoit Mulsant, Sigfried Schouws, Nadine Paans, Sergio Strejilevich, Ashley Sutherland, Shangying Tsai, Betsy Wilson, Lisa T. Eyler
Summary: Literature on older-age bipolar disorder (OABD) is limited. This study analyzed data from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) and found that mood symptom severity was low among older individuals, but functioning was mildly impaired and associated with age and education level. Depressive symptoms were strongly linked to worse functioning in older individuals, highlighting the importance of effective treatments for BD depression in this population.
Article
Psychology, Clinical
David H. Rosmarin, Steven Pirutinsky, Soohyun Park, Mia Drury, David Harper, Brent P. Forester
Summary: This study suggests that among older adults with mood disorders, religious factors, particularly faith in God, are associated with lower levels of suicidality over time. This finding is relevant regardless of religious affiliation, indicating that participation in religious activities and belief in God can reduce the likelihood of experiencing significant suicidality.
PSYCHOLOGICAL MEDICINE
(2023)
Editorial Material
Psychology, Clinical
Regan E. Patrick, Soohyun Park
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Clinical Neurology
Alexandra J. M. Beunders, Federica Klaus, Almar A. L. Kok, Sigfried N. T. M. Schouws, Ralph W. Kupka, Hilary P. Blumberg, Farren Briggs, Lisa T. Eyler, Brent P. Forester, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Benoit H. Mulsant, Regan E. Patrick, Soham Rej, Martha Sajatovic, Kaylee Sarna, Ashley Sutherland, Joy Yala, Eduard Vieta, Luca M. Villa, Nicole C. M. Korten, Annemieke Dols
Summary: This study compared bipolar I disorder (BD-I) and bipolar II disorder (BD-II) in a large, global sample and found no significant differences between the two in terms of general functioning, cognition, and somatic burden. These findings suggest that the distinction between BD-I and BD-II may not be applicable to geriatric bipolar disorder patients.
Article
Clinical Neurology
Amulya Mallu, Carol K. Chan, Lisa T. Eyler, Annemiek Dols, Soham Rej, Hilary P. Blumberg, Kaylee Sarna, Brent P. Forester, Regan E. Patrick, Orestes V. Forlenza, Esther Jimenez, Eduard Vieta, Sigfried Schouws, Ashley Sutherland, Joy Yala, Farren B. S. Briggs, Martha Sajatovic
Summary: This study investigates the relationship between occupational status and other characteristics in older adults with bipolar disorder (OABD). The findings suggest that educational level, age, psychiatric severity, and comorbidity are associated with unemployment in this population.
Meeting Abstract
Clinical Neurology
Lisa Eyler, Martha Sajatovic, Annemiek Dols, Soham Rej, Osvaldo Almeida, Alexandra Beunders, Hilary Blumberg, Farren Briggs, Brent Forester, Regan Patrick, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Eduard Vieta
Meeting Abstract
Geriatrics & Gerontology
Isabella Santangelo, Kathryn Turner, Morgan Green, Regan Patrick, David Harper, Tao Song, Chenyanwen Zhu, Boyu Ren, Brent Forester, Fei Du
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Meeting Abstract
Geriatrics & Gerontology
Jessenia Arias, Regan Patrick, Brent P. Forester
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Meeting Abstract
Geriatrics & Gerontology
Maria DelPico, Keegan Lant, Hannah Heintz, Regan Patrick, Brent Forester
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Meeting Abstract
Geriatrics & Gerontology
Hannah Heintz, Soohyun Park, Regan Patrick, Keegan Lant, Maria DelPico, Boyu Ren, David Harper, Brent Forester
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Meeting Abstract
Geriatrics & Gerontology
Kaitlin McManus, Hailey Cray, Courtney Hsu, Emma Longsjo, Regan Patrick, Ipsit Vahia
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Meeting Abstract
Geriatrics & Gerontology
Kaitlin McManus, Boyu Ren, David Harper, David Olson, Brent Forester, Regan Patrick
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Meeting Abstract
Geriatrics & Gerontology
Soohyun Park, Regan Patrick, Stephen Seiner, Shawn McClintock, Georgios Petrides, Louis Nykamp, Adriana Hermida, Maria Lapid, David Harper, Brent Forester
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)