Validated extended multiplexed LC-MS/MS assay for the quantification of adagrasib and sotorasib in human plasma, together with four additional SMIs

Long-Term Outcomes and Molecular Correlates of Sotorasib Efficacy in Patients With Pretreated KRAS G12C-Mutated Non–Small-Cell Lung Cancer: 2-Year Analysis of CodeBreaK 100

(2023) Grace K. Dy et al.   JOURNAL OF CLINICAL ONCOLOGY

Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG12C mutation: a randomised, open-label, phase 3 trial

(2023) Adrianus Johannes de Langen et al.   LANCET

Validated LC-MS/MS method for simultaneous quantification of KRASG12C inhibitor sotorasib and its major circulating metabolite (M24) in mouse matrices and its application in a mouse pharmacokinetic study

(2023) Irene A. Retmana et al.   Journal of Pharmaceutical and Biomedical Analysis

Simultaneous quantitative detection of afatinib, erlotinib, gefitinib, icotinib, osimertinib and their metabolites in plasma samples of patients with non-small cell lung cancer using liquid chromatography-tandem mass spectrometry

(2022) Xin Xiong et al.   CLINICA CHIMICA ACTA

First-in-Human Phase I/IB Dose-Finding Study of Adagrasib (MRTX849) in Patients With Advanced KRASG12C Solid Tumors (KRYSTAL-1)

(2022) Sai-Hong Ignatius Ou et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapeutic drug monitoring-based precision dosing of oral targeted therapies in oncology: a prospective multicenter study

(2022) S.L. Groenland et al.   ANNALS OF ONCOLOGY

Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRASG12C Mutation

(2022) Pasi A. Jänne et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development and validation of an HPLC–MS/MS method to simultaneously quantify alectinib, crizotinib, erlotinib, gefitinib and osimertinib in human plasma samples, using one assay run

(2021) Ard Veelen et al.   BIOMEDICAL CHROMATOGRAPHY

Quantification of KRAS inhibitor sotorasib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry

(2021) Irene A. Retmana et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors

(2020) David S. Hong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Validated HPLC‐MS/MS method for quantitation of AMG 510, a KRAS G12C inhibitor, in mouse plasma and its application to a pharmacokinetic study in mice

(2020) Naveena Madhyastha et al.   BIOMEDICAL CHROMATOGRAPHY

Validation of an analytical method using HPLC–MS/MS to quantify osimertinib in human plasma and supplementary stability results

(2019) Ard Veelen et al.   BIOMEDICAL CHROMATOGRAPHY