Article
Multidisciplinary Sciences
Gabela Nelson, Alexis Strain, Atsuko Isu, Alireza Rahnama, Ken-ichi Wakabayashi, Adam T. T. Melvin, Naohiro Kato
Summary: The mechanisms governing chemotaxis in Chlamydomonas reinhardtii are still poorly understood. In this study, a modified Petri dish assay revealed a novel mechanism for ammonium chemotaxis in Chlamydomonas. Light exposure enhanced the chemotactic response, but phototaxis-incompetent mutant strains still exhibited normal chemotaxis. Collective migration was observed during chemotaxis but not phototaxis. The AGG1 protein was found to suppress collective migration during chemotaxis.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Guzel Burganova, Claire Bridges, Peter Thorn, Limor Landsman
Summary: Insulin-producing beta-cells are the majority in pancreatic islets and their dysfunction is a key factor in the loss of glucose regulation in type 2 diabetes. The close interaction between beta-cells and the intra-islet microvasculature, which includes endothelial cells and pericytes, plays a crucial role in regulating beta-cell functions. The vascular cells directly regulate beta-cell activity through the secretion of growth factors and other molecules, promoting insulin gene expression, insulin secretion, and beta-cell proliferation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Jan K. Hennigs, Christiane Matuszcak, Martin Trepel, Jakob Koerbelin
Summary: Endothelial cells play crucial roles in facilitating physiological processes throughout the body, demonstrating tremendous cellular diversity. Different endothelial cell populations adapt to the specific needs of various organs and tissues, influencing vascular tone, blood coagulation, and cellular adhesion.
Review
Biochemistry & Molecular Biology
Lan-Lan Bu, Huan-Huan Yuan, Ling-Li Xie, Min-Hua Guo, Duan-Fang Liao, Xi-Long Zheng
Summary: This review examines the molecular mechanisms and functional alterations associated with endothelial cell senescence and death in different stages of atherosclerosis, highlighting the various factors and forms of cell death involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Meng-Ting Li, Jia Ke, Shu-Fen Guo, Li-Li Shan, Jia-Hao Gong, Tian-Ci Qiao, Hao-Yu Tian, Yang Wu, Zheng-Yu Peng, Xue-Qian Zeng, Yan Han
Summary: HZQMY could promote cell proliferation, cell migration, angiogenesis, reduce mitochondrial membrane potential damage and inhibit apoptosis, possibly by regulating key targets such as IL-1β, ICAM-1, VCAM-1, and VEGF to treat CSVD.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Nutrition & Dietetics
Hanxu Zhang, Shuang Zhou, Minxue Sun, Manqi Hua, Zhiyan Liu, Guangyan Mu, Zhe Wang, Qian Xiang, Yimin Cui
Summary: The review discusses the role of ferroptosis in endothelial cells in vascular diseases and explores potential therapeutic strategies for treating ferroptosis.
Review
Oncology
Antonio Filippini, Luca Tamagnone, Alessio D'Alessio
Summary: Recent findings suggest that targeting endothelial cell metabolism may be an alternative strategy for antiangiogenic therapy and a novel approach for treating cardiovascular diseases. Understanding how endothelial cells adapt their metabolic status in response to changes in the tissue microenvironment could help develop innovative treatments to counteract abnormal blood vessel growth.
Article
Oncology
LaDeidra Monet Roberts, Matthew J. Perez, Kristen N. Balogh, Garnett Mingledorff, Janet Cross, Jennifer M. Munson
Summary: This article describes the development of a breast tumor microenvironment model that includes primary-derived mouse MDSCs. The authors explore the interactions driving MDSC migration through both biophysical and cellular signaling events within the tumor microenvironment. The results indicate that interstitial fluid flow plays a key role in MDSC migration.
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Immunology
Xiaohong Fei, Xuejiang Cen, Ruochi Zhao, Jian Wang, Hanbin Cui
Summary: Atherosclerosis is the pathological basis of cardiovascular disease, which begins with endothelial dysfunction caused by vascular endothelial cell injury. PRMT5, a protein arginine methyltransferase, is highly related to cardiovascular events. This study aimed to explore the biological roles of PRMT5/PDCD4 in vascular endothelial cell injury during atherosclerosis. Results showed that PRMT5 was highly expressed in ox-LDL-stimulated HUVECs. Knockdown of PRMT5 enhanced cell viability and inhibited apoptosis, oxidative stress, inflammation, and endothelial dysfunction in HUVECs. PRMT5 was found to interact and bind with PDCD4. In conclusion, down-regulation of PRMT5 exerts protective effects against vascular endothelial cell injury during atherosclerosis by suppressing PDCD4 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Taku Wakabayashi, Hisamichi Naito
Summary: Vascular endothelial cells (ECs) are crucial for new vessel formation and organ homeostasis. Advances in single cell RNA sequencing (scRNA-seq) have revealed the heterogeneity of ECs in mice and humans, identifying molecular signatures and specialized subtypes. scRNA-seq has also documented the gene expression profiles of tissue-resident ECs involved in angiogenesis, as well as the responses of ECs in various diseases. These findings have significant implications for potential therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Feng Luo, Ruyi Li, Huaping Zheng, Yichen Xu, Linxin Yang, Changxing Qu, Guang Hong, Qianbing Wan
Summary: Carbon nanotubes (CNTs) are a promising bioactive scaffold for bone regeneration, but their effect on vascularization is minimal. In this study, SWNTs/EDC composite was found to promote the differentiation of bone mesenchymal stem cells (BMSCs) into vascular endothelial cell-like cells (VEC-like cells) and positively affect angiogenesis and bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Yanfen Cui, Hui Liu, Zhaosong Wang, He Zhang, Jianfei Tian, Zhiyong Wang, Weijie Song, Hui Guo, Liming Liu, Ruinan Tian, Xiaoyan Zuo, Sixin Ren, Fei Zhang, Ruifang Niu
Summary: High fructose intake is associated with increased risk of multiple cancers. Fructose can enhance the biological function of vascular endothelial cells (VECs) and promote angiogenesis by activating the Akt and Src signaling pathways. It can also upregulate production of reactive oxygen species (ROS) in colorectal cancer cells, indirectly enhancing the function of VECs. These findings have been validated in clinical colorectal cancer tissues and mouse models.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ningning Sun, Beyongsam Chu, Dong-Hyun Choi, Leejin Lim, Heesang Song
Summary: Abnormal communication between endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) promotes vascular diseases. ETS variant transcription factor 2 (ETV2) plays a role in pathological angiogenesis, but its role in the communication between ECs and VSMCs is unknown. CXCL5 induced by ETV2 in ECs promotes VSMC migration through MMP upregulation and the activation of Akt and p38/c-Jun.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Tianying Hong, Xianmei Pan, Han Xu, Zhijuan Zheng, Lizhen Wen, Jing Li, Mingfeng Xia
Summary: Vascular inflammation is a common pathological basis for many cardiovascular diseases. Jatrorrhizine, a component of Rhizoma Coptidis, has been found to reduce carotid intimal hyperplasia and vascular inflammation in mice, and inhibit endothelial cell inflammation induced by H2O2.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Rie Utoh, Junji Komori, Hiroyuki Kuge, Kohei Tatsumi, Masumi Yamada, Shinji Hirohashi, Masahiro Tsutsumi, Toshihiro Amanuma, Akira Yoshioka, Yoshiyuki Nakajima, Kenjiro Wake, Teruo Okano, Eric Lagasse, Kazuo Ohashi
JOURNAL OF HEPATOLOGY
(2018)
Article
Polymer Science
Jun Akimoto, Yoshihiro Ito, Teruo Okano, Masamichi Nakayama
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
(2018)
Article
Polymer Science
Yoshikatsu Akiyama, Teruo Okano
KOBUNSHI RONBUNSHU
(2018)
Review
Pharmacology & Pharmacy
Hironobu Takahashi, Teruo Okano
ADVANCED DRUG DELIVERY REVIEWS
(2019)
Article
Cell & Tissue Engineering
Jong-Min Lee, Hyun-Yi Kim, Jin-Sung Park, Dong-Joon Lee, Sushan Zhang, David William Green, Teruo Okano, Jeong-Ho Hong, Han-Sung Jung
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Robotics
Kaoru Uesugi, Yui Sakuma, Yoshitake Akiyama, Yoshikatsu Akiyama, Kikuo Iwabuchi, Teruo Okano, Keisuke Morishima
Article
Engineering, Biomedical
Jun Akimoto, Masamichi Nakayama, Soichi Takagi, Teruo Okano
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Review
Engineering, Biomedical
Jun Kobayashi, Akihiko Kikuchi, Takao Aoyagi, Teruo Okano
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Review
Chemistry, Multidisciplinary
Jun Kobayashi, Teruo Okano
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2019)
Article
Cell & Tissue Engineering
Nobuyuki Kaibuchi, Takanori Iwata, Satoru Onizuka, Kosei Yano, Yuka Tsumanuma, Masayuki Yamato, Teruo Okano, Tomohiro Ando
REGENERATIVE THERAPY
(2019)
Editorial Material
Cell & Tissue Engineering
Kyungsook Kim, David W. Grainger, Teruo Okano
REGENERATIVE THERAPY
(2019)
Article
Computer Science, Artificial Intelligence
Hyeonwoo Cho, Kazuya Nishimura, Kazuhide Watanabe, Ryoma Bise
Summary: Cell detection is an important task in biomedical research, and deep learning methods have been used to improve its performance. However, the domain shift problem arises when a detection network trained with specific conditions fails to perform well on data from different conditions. This study proposes an unsupervised domain adaptation method for cell detection using a pseudo-cell-position heatmap and selective pseudo-labeling, which showed improved performance compared to existing methods under various conditions.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Computer Science, Artificial Intelligence
Hiroki Okawa, Mihoko Shimano, Yuta Asano, Ryoma Bise, Ko Nishino, Imari Sato
Summary: Recognizing wet surfaces and their degrees of wetness is important for computer vision applications. This paper introduces a method based on spectral characteristics to recover the original color and degree of wetness of wet surfaces from a single multispectral image.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2022)
Article
Dermatology
Yuki Ogura, Mihoko Shimano, Ryoma Bise, Toyonobu Yamashita, Chika Katagiri, Imari Sato
Summary: The skin is made up of different layers with specific optical properties due to differences in biological components. Chronic exposure to UV light can cause changes in the skin's biological components, affecting its appearance. Previous methods for analyzing cutaneous optical properties were insufficient, so we developed a new technique to study the yellowing of facial skin caused by UV exposure. We found that aged skin has increased absorption at 450 nm, where yellowish colors are complemented, and elastic fibers with histological disorder are a prominent source of high optical absorption.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Computer Science, Information Systems
Takeaki Kadota, Kentaro Abe, Ryoma Bise, Takuji Kawamura, Naokuni Sakiyama, Kiyohito Tanaka, Seiichi Uchida
Summary: In this study, a multi-task learning method for automatically estimating disease-severity levels is proposed. By combining learning to rank with regression, the method enables the use of relative-level and a small number of absolute-level annotations for training, leading to accurate disease-severity classification and estimation.
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)