The Role of Long-Acting Antimuscarinic Agents in the Treatment of Asthma

The Impact of Tobacco Smoking on Adult Asthma Outcomes

(2021) Angelica Tiotiu et al.   International Journal of Environmental Research and Public Health

Inhaled long-acting muscarinic antagonists in asthma – A narrative review

(2021) Alberto Papi et al.   European Journal of Internal Medicine

Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma

(2021) Lisa H. Y. Kim et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tiotropium bromide as adjunct therapy in children with asthma: a clinical experience

(2021) Zainab Ridha et al.   Allergy Asthma and Clinical Immunology

A review of the pharmacokinetics of M3 muscarinic receptor antagonists used for the treatment of asthma

(2020) Maria Gabriella Matera et al.   Expert Opinion on Drug Metabolism & Toxicology

The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS)

(2020) Timothy E. Albertson et al.   EXPERT OPINION ON PHARMACOTHERAPY

Extrafine triple therapy in patients with asthma and persistent airflow limitation

(2020) Dave Singh et al.   EUROPEAN RESPIRATORY JOURNAL

Fixed-dose combination of indacaterol/glycopyrronium/mometasone furoate once-daily versus salmeterol/fluticasone twice-daily plus tiotropium once-daily in patients with uncontrolled asthma: A randomised, Phase IIIb, non-inferiority study (ARGON)

(2020) Christian Gessner et al.   RESPIRATORY MEDICINE

Randomized controlled trial of triple versus dual inhaler therapy on small airways in smoking asthmatics

(2020) Sunny Jabbal et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Once-daily, single-inhaler mometasone–indacaterol–glycopyrronium versus mometasone–indacaterol or twice-daily fluticasone–salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study

(2020) Huib A M Kerstjens et al.   Lancet Respiratory Medicine

Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial

(2020) Laurie A Lee et al.   Lancet Respiratory Medicine

Managing Asthma in Adolescents and Adults

(2020) Michelle M. Cloutier et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tiotropium is efficacious in 6–17-year-olds with asthma, independent of T2 phenotype

(2019) Stanley J. Szefler et al.   Journal of Allergy and Clinical Immunology-In Practice

Inhaled Glucocorticoid with or without Tiotropium Bromide for Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome

(2019) Hailing Xu et al.   JCPSP-Journal of the College of Physicians and Surgeons Pakistan

Dynamic hyperinflation impairs daily life activity in asthma

(2019) A. N. van der Meer et al.   EUROPEAN RESPIRATORY JOURNAL

Towards clinically applicable biomarkers for asthma – An EAACI position paper

(2019) Zuzana Diamant et al.   ALLERGY

Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level

(2019) Stephen C. Lazarus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms and therapeutic strategies for Non‐T2 Asthma

(2019) Eric Sze et al.   ALLERGY

Pharmacological characterization of the interaction between tiotropium bromide and olodaterol on human bronchi and small airways

(2019) Luigino Calzetta et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Tiotropium in asthma: From bench to bedside

(2019) Lyndon Mansfield et al.   RESPIRATORY MEDICINE

Burden of Asthma and Role of 2.5 µg Tiotropium Respimat® as an Add-On Therapy: A Systematic Review of Phase 2/3 Trials

(2019) Lyndon Mansfield et al.   ADVANCES IN THERAPY

Effect of Tiotropium Bromide on Airway Inflammation and Programmed Cell Death 5 in a Mouse Model of Ovalbumin-Induced Allergic Asthma

(2019) Juan Wang et al.   Canadian Respiratory Journal

Management of Severe Asthma: a European Respiratory Society/American Thoracic Society Guideline

(2019) Fernando Holguin et al.   EUROPEAN RESPIRATORY JOURNAL

Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two double-blind, parallel-group, randomised, controlled phase 3 trials

(2019) Johann Christian Virchow et al.   LANCET

Clinical predictors of asthmatics in identifying subgroup requiring long-term tiotropium add-on therapy: a real-world study

(2019) Wen-Chien Cheng et al.   Journal of Thoracic Disease

Muscarinic receptor M3 contributes to vascular and neural growth factor up‐regulation in severe asthma

(2019) Anna Folino et al.   ALLERGY

Beclomethasone dipropionate, formoterol fumarate and glycopyrronium bromide: synergy of triple combination therapy on human airway smooth muscle ex vivo

(2019) Paola Rogliani et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy of once-daily tiotropium Respimat in adults with asthma at GINA Steps 2–5

(2019) Roland Buhl et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Efficacy, safety, and dose response of glycopyrronium administered by metered dose inhaler using co-suspension delivery technology in subjects with intermittent or mild-to-moderate persistent asthma: A randomized controlled trial

(2018) Edward Kerwin et al.   RESPIRATORY MEDICINE

Possible involvement of acetylcholine-mediated inflammation in airway diseases

(2018) Akira Koarai et al.   ALLERGOLOGY INTERNATIONAL

Clinical predictors of the effectiveness of tiotropium in adults with symptomatic asthma: a real-life study

(2018) Wen-Chien Cheng et al.   Journal of Thoracic Disease

Safety and efficacy of tiotropium in children aged 1–5 years with persistent asthmatic symptoms: a randomised, double-blind, placebo-controlled trial

(2018) Elianne J L E Vrijlandt et al.   Lancet Respiratory Medicine

Dual LABA/LAMA bronchodilators in chronic obstructive pulmonary disease: why, when, and how

(2018) Luigino Calzetta et al.   Expert Review of Respiratory Medicine

Tiotropium Respimat Add-on Is Efficacious in Symptomatic Asthma, Independent of T2 Phenotype

(2018) Thomas B. Casale et al.   Journal of Allergy and Clinical Immunology-In Practice

Clinical Approach to the Therapy of Asthma-COPD Overlap

(2018) Diego J. Maselli et al.   CHEST

The mode of action of anticholinergics in asthma

(2018) Reinoud Gosens et al.   EUROPEAN RESPIRATORY JOURNAL

Tiotropium add-on to inhaled corticosteroids versus addition of long-acting β2-agonists for adults with asthma

(2018) Roland Buhl et al.   RESPIRATORY MEDICINE

Tiotropium for the treatment of asthma in adolescents

(2017) Eckard Hamelmann et al.   EXPERT OPINION ON PHARMACOTHERAPY

Pharmacokinetics of tiotropium administered by Respimat® in asthma patients: Analysis of pooled data from Phase II and III clinical trials

(2017) Ashish Sharma et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The effect of tiotropium in combination with olodaterol on house dust mite-induced allergic airway disease

(2017) Gerrit John-Schuster et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Effects of tiotropium on lung function in current smokers and never smokers with bronchial asthma

(2017) Makoto Yoshida et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Role of muscarinic antagonists in asthma therapy

(2017) Mario Cazzola et al.   Expert Review of Respiratory Medicine

Effects of the addition of tiotropium on airway dimensions in symptomatic asthma

(2016) Makoto Hoshino et al.   ALLERGY AND ASTHMA PROCEEDINGS

A randomised controlled trial of tiotropium in adolescents with severe symptomatic asthma

(2016) Eckard Hamelmann et al.   EUROPEAN RESPIRATORY JOURNAL

Once-Daily Tiotropium Respimat® Add-on to at Least Ics Maintenance Therapy in Patients with Symptomatic Asthma: Methodology of Modeling Analyses By Serum IgE and Blood Eosinophil Levels

(2016) Hendrik Schmidt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tiotropium add-on therapy in adolescents with moderate asthma: A 1-year randomized controlled trial

(2016) Eckard Hamelmann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interaction between corticosteroids and muscarinic antagonists in human airways

(2016) Mario Cazzola et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Can bronchial asthma with an highly prevalent airway (and systemic) vagal tone be considered an independent asthma phenotype? Possible role of anticholinergics

(2016) Gennaro Liccardi et al.   RESPIRATORY MEDICINE

Safety and tolerability of once-daily tiotropium Respimat ® as add-on to at least inhaled corticosteroids in adult patients with symptomatic asthma: A pooled safety analysis

(2016) Ronald Dahl et al.   RESPIRATORY MEDICINE

Tiotropium improves lung function, exacerbation rate, and asthma control, independent of baseline characteristics including age, degree of airway obstruction, and allergic status

(2016) Huib A.M. Kerstjens et al.   RESPIRATORY MEDICINE

Tiotropium in the add-on treatment of asthma in adults: clinical trial evidence and experience

(2016) Christian Vogelberg   Therapeutic Advances in Respiratory Disease

The Effect of Tiotropium in Symptomatic Asthma Despite Low- to Medium-Dose Inhaled Corticosteroids: A Randomized Controlled Trial

(2016) Pierluigi Paggiaro et al.   Journal of Allergy and Clinical Immunology-In Practice

Tiotropium in asthma: what is the evidence and how does it fit in?

(2016) David M. G. Halpin   World Allergy Organization Journal

Pharmacological interaction between LABAs and LAMAs in the airways: optimizing synergy

(2015) Luigino Calzetta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The effect of fluticasone furoate/umeclidinium in adult patients with asthma: A randomized, dose-ranging study

(2015) Laurie A. Lee et al.   RESPIRATORY MEDICINE

A randomized, three-period crossover study of umeclidinium as monotherapy in adult patients with asthma

(2015) Laurie A. Lee et al.   RESPIRATORY MEDICINE

Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling

(2015) Loes E.M. Kistemaker et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Safety of inhaled glycopyrronium in patients with COPD: a comprehensive analysis of clinical studies and post-marketing data

(2015) Tony D’Urzo et al.   International Journal of Chronic Obstructive Pulmonary Disease

Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trials

(2015) Huib A M Kerstjens et al.   Lancet Respiratory Medicine

Long-Term Once-Daily Tiotropium Respimat® Is Well Tolerated and Maintains Efficacy over 52 Weeks in Patients with Symptomatic Asthma in Japan: A Randomised, Placebo-Controlled Study

(2015) Ken Ohta et al.   PLoS One

Tiotropium may improve asthma symptoms and lung function in asthmatic patients with irreversible airway obstruction: the real-life data

(2014) Oznur Abadoglu et al.   Clinical Respiratory Journal

Pooled safety analysis of the fixed-dose combination of indacaterol and glycopyrronium (QVA149), its monocomponents, and tiotropium versus placebo in COPD patients

(2014) Jadwiga A. Wedzicha et al.   RESPIRATORY MEDICINE

Tiotropium in asthmatic adolescents symptomatic despite inhaled corticosteroids: A randomised dose-ranging study

(2014) Christian Vogelberg et al.   RESPIRATORY MEDICINE

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

(2013) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Tiotropium bromide inhibits relapsing allergic asthma in BALB/c mice

(2013) Berislav Bosnjak et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Effect of tiotropium bromide on airway remodeling in a chronic asthma model

(2012) Ji Young Kang et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma

(2012) KS Buels et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy

(2012) Huib A.M. Kerstjens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Severe asthma: Advances in current management and future therapy

(2011) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

“Divine Stramonium”: The Rise and Fall of Smoking for Asthma

(2011) Mark Jackson   MEDICAL HISTORY

A role for sensory nerves in the late asthmatic response

(2011) Kristof Raemdonck et al.   THORAX

Muscarinic receptor antagonists, from folklore to pharmacology; finding drugs that actually work in asthma and COPD

(2010) Bart C Moulton et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma

(2010) S. Ohta et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Aclidinium bromide abrogates allergen-induced hyperresponsiveness and reduces eosinophilia in murine model of airway inflammation

(2010) Gautam Damera et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tiotropium Bromide Step-Up Therapy for Adults with Uncontrolled Asthma

(2010) Stephen P. Peters et al.   NEW ENGLAND JOURNAL OF MEDICINE

Additive role of tiotropium in severe asthmatics and Arg16Gly inADRB2as a potential marker to predict response

(2009) H.-W. Park et al.   ALLERGY

Increased parasympathetic tone as the underlying cause of asthma: A hypothesis

(2009) Manish Goyal et al.   MEDICAL HYPOTHESES

Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype

(2008) H. Iwamoto et al.   EUROPEAN RESPIRATORY JOURNAL

Improvements with tiotropium in COPD patients with concomitant asthma

(2007) H. Magnussen et al.   RESPIRATORY MEDICINE