Journal
MICROCHIMICA ACTA
Volume 183, Issue 10, Pages 2723-2731Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-016-1917-1
Keywords
Theranostics; Platinum porphyrins; Dodecyltrimethoxysilane; Singlet oxygen; Intramitochondrial oxygen; Time-resolved fluorescence
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Funding
- National Basic Research Program of China (973 Program) [2014CC339900]
- Chinese Postdoctoral Science Foundation [2016 M591126]
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We report on a novel kind of mitochondria-targeted theranostic nanoparticles (NPs). The NPs are doped with the oxygen-sensitive probe Pt(II)-porphyrins (PtTFPP) which exerts a dual role in acting as a diagnostic tool that can sense oxygen via quenching of luminescence, but also acts as an agent in photodynamic therapy (PDT) of cancer. In addition, it allows therapeutic efficacy to be assessed in-situ. Upon appropriate high-energy photoirradiation, the NPs generate singlet oxygen by energy transfer from triplet PtTFPP to ground state oxygen, and cell death is induced via PDT. Under low-energy light irradiation, in contrast, the NPs can be utilized to detect oxygen consumption rate via time-resolved luminescence measurements in order to study the efficacy of PDT. This is the first report where a single nanoagent is used to stimulate PDT and also to assess the efficacy of PDT. In our perception, the method provides a promising platform for testing anti-cancer drugs.
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