Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 69, Pages 13365-13368Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc05005g
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Funding
- MINECO [RYC-2012-09873]
- European Commission via the ITN ECHONET network [MCITN-2012-316379]
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The direct alpha-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process. This practical oxidative method allowed the efficient C2-alkylation of a variety of (benzo) azoles constituting straightforward access to heterocycles of utmost medicinal significance and highlighting the convenient use of feedstock substrates and iron catalysts. A preliminary mechanism supported by DFT calculations is discussed as well.
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