Article
Nutrition & Dietetics
Li Li, Qi Huang, Linjian Yang, Rui Zhang, Leili Gao, Xueyao Han, Linong Ji, Xiantong Zou
Summary: There is an association between non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) with levels of vitamin B12 and associated metabolites, while MMA and HCY may be associated with an increased risk for advanced fibrosis.
Article
Nutrition & Dietetics
Haofeng Hong, Longting Chen, Yiming Zhong, Zihuan Yang, Weishi Li, Chunli Song, Huijie Leng
Summary: This study used a Mendelian randomization approach to investigate the potential causal effects of homocysteine, folate, and vitamin B12 on site- and gender-specific osteoarthritis (OA). The results showed that genetically predicted homocysteine had adverse effects on OA, while genetically predicted folate and vitamin B12 had protective effects on OA.
Article
Nutrition & Dietetics
Ziva Lavrisa, Hristo Hristov, Masa Hribar, Katja Zmitek, Anita Kusar, Barbara Korousic Seljak, Matej Gregoric, Urska Blaznik, Nadan Gregoric, Katja Zaletel, Adrijana Oblak, Josko Osredkar, Igor Pravst
Summary: Vitamin B12 deficiency is a common issue in the Slovenian population, especially among the elderly. Lower intake is observed in females, and meat and milk are the main contributors to vitamin B12 intake across all age groups. Serum vitamin B12 levels have a significant impact on the health of the elderly.
Review
Endocrinology & Metabolism
Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Ali Al-kassab-Cordova, Juan C. Cabrera-Guzman, Percy Herrera-Anazco, Vicente A. Benites-Zapata
Summary: This systematic review and meta-analysis assessed the association of vitamin B12, folic acid, and homocysteine (Hcy) levels with MetS. The results showed that higher vitamin B12 levels were inversely associated with MetS, whereas higher Hcy levels were positively associated with MetS. Folate levels were not associated with MetS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Patricia Lipari Pinto, Cristina Florindo, Patricia Janeiro, Rita Loureiro Santos, Sandra Mexia, Hugo Rocha, Isabel Tavares de Almeida, Laura Vilarinho, Ana Gaspar
Summary: Early diagnosis and intervention in vitamin B12 deficiency in exclusively breastfed infants by mothers with low vitamin B12 are crucial in preventing irreversible neurologic damage, megaloblastic anemia, and failure to thrive. Monitoring serum vitamin B12 levels during pregnancy is important. Acquired B12 deficiency should be ruled out before proceeding in a differential diagnosis of cobalamin metabolism deficits, methylmalonic acidemia, and homocystinuria.
Article
Nutrition & Dietetics
Winner Kucha, Daniel Seifu, Abenezer Tirsit, Mahlet Yigeremu, Markos Abebe, Dawit Hailu, Dareskedar Tsehay, Solomon Genet
Summary: The study found that deficiency in folate and vitamin B12 in the blood of pregnant women may be associated with neural tube defects. There is a correlation between the use of folate/multivitamins and neural tube defects.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Giulietta S. Monasso, Janine F. Felix, Sandra G. Heil, Yolanda B. de Rijke, Romy Gaillard, Vincent W. V. Jaddoe
Summary: The study found associations between circulating vitamin B12, folate, and homocysteine concentrations during fetal life and early signs of atherosclerosis in school-age children, but only certain biochemical markers showed impact.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Panpan Zhang, Xia Xie, Yurong Zhang
Summary: This study investigated the associations between plasma homocysteine (Hcy), vitamin B12, and folate levels and the risk of all-cause mortality in American adults with stroke. The results showed a significant positive association between plasma Hcy levels and all-cause mortality in stroke patients, while no significant associations were found between plasma folate and vitamin B12 levels and all-cause mortality.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Julia L. Finkelstein, Amy Fothergill, Jesse T. Krisher, Tinku Thomas, Anura Kurpad, Pratibha Dwarkanath
Summary: This study conducted in Bangalore, India found a high prevalence of vitamin B-12 deficiency during early pregnancy, which was associated with neonatal vitamin B-12 status. Higher maternal vitamin B-12 levels were linked to increased neonatal vitamin B-12 levels, reducing the risk of deficiency in newborns.
Article
Nutrition & Dietetics
Sigrun Henjum, Synne Groufh-Jacobsen, Allen Lindsay, Ellen Raael, Anna Maria Israelsson, Setareh Shahab-Ferdows, Daniela Hampel
Summary: Plant-based diets may lead to vitamin B12 deficiency, but folate intake is increased. A study on Norwegian vegans and vegetarians found that their B12 status was adequate, while folate levels were higher in vegetarians.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Jacob Selhub, Joshua W. Miller, Aron M. Troen, Joel B. Mason, Paul F. Jacques
Summary: This article proposes a hypothesis that excessive intake of folic acid depletes serum holotranscobalamin, decreasing active vitamin B-12 in the circulation and limiting its availability for tissues. The study provides evidence from observational and intervention studies, and suggests that further research is needed to elucidate the biochemical and physiological mechanisms underlying this interaction.
ADVANCES IN NUTRITION
(2022)
Review
Food Science & Technology
Linnea Barebring, Christel Lamberg-Allardt, Birna Thorisdottir, Alfons Ramel, Fredrik Soderlund, Erik Kristoffer Arnesen, Bright I. Nwaru, Jutta Dierkes, Agneta Akesson
Summary: This systematic review aimed to assess the evidence for whether habitual or different levels of experimental intake of vitamin B12 from diet and supplements is sufficient to ensure adequate B12 status in groups most susceptible to vitamin B12 deficiency. The search yielded 18 included studies, and the conclusion was that the evidence is currently insufficient to determine if or which level of B12 intake is sufficient to maintain adequate status for all included populations.
FOOD & NUTRITION RESEARCH
(2023)
Review
Medical Laboratory Technology
Agata Sobczynska-Malefora, Edgard Delvin, Andrew McCaddon, Kourosh R. Ahmadi, Dominic J. Harrington
Summary: Vitamin B-12 is an essential cofactor in two metabolic pathways and is primarily obtained from animal-based foods. Deficiency in B-12 can mimic various illnesses and requires attention from different medical specialists for accurate diagnosis and treatment. Current tests and treatment options for B-12 deficiency have limitations that need to be addressed for better assessment and management.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Madhulika Tripathi, Brijesh Kumar Singh, Jin Zhou, Keziah Tikno, Anissa Widjaja, Reddemma Sandireddy, Kabilesh Arul, Siti Aishah Binte Abdul Ghani, George Goh Boon Bee, Kiraely Adam Wong, Ho Jia Pei, Shamini Guna Shekeran, Rohit Anthony Sinha, Manvendra K. Singh, Stuart Alexander Cook, Ayako Suzuki, Teegan Reina Lim, Chang-Chuen Cheah, Jue Wang, Rui-Ping Xiao, Xiuqing Zhang, Pierce Kah Hoe Chow, Paul Michael Yen
Summary: The study reveals that hyperhomocysteinemia (HHcy) plays a key role in the pathogenesis of non-alcoholic steatohepatitis (NASH) through homocysteinylation of proteins, leading to autophagy blockage. Vitamin B-12 and folate may serve as a novel first-line therapy for NASH by reducing homocysteine levels and promoting autophagy, thus improving liver histology.
JOURNAL OF HEPATOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xiaoheng Xu, Yang Liu, Xiaoqin Xiong, Yanmei Yao, Huiting Hu, Xiao Jiang, Wenxia Meng
Summary: This study aimed to investigate the diagnostic value of a visible beefy red patch and accessible fingertip mean corpuscular volume (MCV) in the diagnosis of vitamin B12 deficiency. The results showed that in local clinics and hospitals without in-house clinical laboratories in China, the combination of beefy red patch and MCV could improve the diagnosis rate of VB12 deficiency, especially in the elderly, leading to early disease detection and treatment.