Article
Polymer Science
Pieter-Jan Voorter, Manfred Wagner, Christine Rosenauer, Jinhuo Dai, Priya Subramanian, Alasdair Mckay, Neil R. Cameron, Jasper J. Michels, Tanja Junkers
Summary: Diffusion-ordered NMR spectroscopy (DOSY) is a solvent-independent method for molecular weight calibration with low lab variability. It has been used for data calibration in different solvents and confirmed the inter-laboratory and inter-polymer consistency. It can also determine the molecular weight of polymers with added complexity.
Review
Spectroscopy
Mikael Fabritius, Baoru Yang
Summary: Analysis of triacylglycerol (TG) and phospholipid sn-positional isomers can be done through direct separation or quantification of regioisomer ratios using mass spectrometry. Direct chromatography separation is being replaced by mass spectrometry due to limitations. However, challenges arise from the large number of isobaric and isomeric lipid species in natural samples and the lack of available regiopure standards. Optimization algorithms and fragmentation models are useful for analysis of TG regioisomers.
MASS SPECTROMETRY REVIEWS
(2023)
Article
Chemistry, Analytical
Amarande Murisier, Marie Andrie, Szabolcs Fekete, Matthew Lauber, Valentina D'Atri, Katharina Iwan, Davy Guillarme
Summary: This study describes the use of an innovative bioinert size exclusion chromatography column to characterize the size variance of complex monoclonal antibody products. The column, which includes a novel column hardware surface, successfully improves peak tailing, band broadening, and recovery of high molecular weight species compared to a reference stainless-steel column. The study also found that a 50 mM ammonium acetate solution is suitable for liquid chromatography performance and mass spectrometry sensitivity.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Engineering, Environmental
Le Min Chen, Stefan de Bruin, Mario Pronk, Diana Z. Sousa, Mark C. M. van Loosdrecht, Yuemei Lin
Summary: This study investigates the sialylation and sulfation of anionic glycoconjugates in anaerobic and aerobic granular sludge. The results showed that these two glycoconjugate modifications commonly occur in the extracellular polymericsubstances (EPS) of both types of sludge. Mass spectrometry analysis and gene identification provided insights into the distribution and synthesis of these modifications in the sludge communities.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Jun Dai, Chengjie Ji
Summary: Although reversed-phase liquid chromatography (RPLC) is commonly used, other separation modes such as size exclusion chromatography (SEC) and ion-exchange chromatography (IEX) are crucial for characterizing protein therapeutics. This study demonstrates the power of native mass spectrometry (MS) coupled with SEC and IEX for the characterization of bevacizumab and NISTmAb, providing valuable insights into the protein therapeutics at the native state.
ANALYTICA CHIMICA ACTA
(2023)
Article
Agriculture, Multidisciplinary
Michaela Maleckova, Tomas Vrzal, Jana Olsovska, Jana Sobotnikova
Summary: This study focuses on the identification and structural characterization of nitrite reaction products in beer, discovering 19 representatives of nitroso, nitro, oxime, and even cyano compounds. The presence of these compounds in non-treated beers was confirmed through screening in 16 authentic beer samples.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Chemistry, Analytical
Szabolcs Fekete, Megane K. Aebischer, Mateusz Imiolek, Tobias Graf, Raphael Ruppert, Matthew Lauber, Valentina D'Atri, Davy Guillarme
Summary: In recent years, there has been a significant increase in the biopharmaceutical industry's interest in gene therapy modalities. Fit-for-purpose analytical methods are crucial to ensure the quality of gene therapy products during manufacturing and upstream/downstream process. However, the characterization of these products remains challenging due to their large size, structural complexity, heterogeneity, potential instability, and limited sample availability. This review focuses on the use of liquid chromatography (LC) based methods for analyzing adeno-associated virus (AAV) vector-based gene therapy products, highlighting their advantages, drawbacks, and unique capabilities in the analysis of AAV gene transfer vehicles and their impurities.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Food Science & Technology
Kelly Peeters, Angelica Tamayo Tenorio
Summary: Rapeseed meal and pressed cake are protein-rich by-products from rapeseed after oil extraction, and their protein extraction requires attention to high erucic acid content. The Soxhlet procedure was found to yield the highest concentrations of erucic acid, with potential implications for safety and accurate analysis in rapeseed protein products.
Article
Chemistry, Analytical
Veronika Pilarova, Zuzana Hadysova, Frantisek Svec, Lucie Novakova
Summary: A fast, selective, and sensitive analysis method has been developed for the determination of various neutral and acidic phytocannabinoids with an emphasis on the separation of structurally related compounds. Through optimized chromatography, mass spectrometry, and extraction methods, the study successfully applied the technique to detect cannabinoids in different products.
ANALYTICA CHIMICA ACTA
(2022)
Review
Chemistry, Analytical
Bastiaan L. Duivelshof, Amarande Murisier, Julien Camperi, Szabolcs Fekete, Alain Beck, Davy Guillarme, Valentina D'Atri
Summary: Fc-fusion proteins are a successful class of biopharmaceutical products with diverse biological ligands, combining tailored pharmacological properties and multiple functions of immunoglobulins. Analyzing Fc-fusion proteins is more complex than monoclonal antibodies due to their highly diverse structures, requiring the development of specific methods for characterization.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Chemistry, Applied
Delia Castilla-Fernandez, David Moreno-Gonzalez, Juan F. Garcia-Reyes, Evaristo Ballesteros, Antonio Molina-Diaz
Summary: Datura species are known for their high concentration of tropane alkaloids, which can lead to poisoning when accidentally mixed with edible crops. Testing on frozen spinach and spinach-based infant food products found that some samples had levels close to the maximum limits set by the European Union. This highlights the global concern over the presence of these compounds in various commodities.
Article
Polymer Science
Tereza Jurczykova, Frantisek Kacik, Iveta Cabalova, Katerina Hajkova
Summary: This study evaluates the effect of using inorganic chemicals as the main components of waterborne wood preservative systems on the degradation of cellulose in wood. It shows that the polymeric properties of cellulose and the homogeneity of the degradation process reflect the degree of cellulose deterioration. The results suggest that borates, NaCl, and ZnSO4 center dot 7H(2)O have the lowest degradation rate, while sulphates containing NH4+, Cu2+, and Fe3+ cations cause significant depolymerization.
Article
Biochemistry & Molecular Biology
Nitika Nitika, Hemlata Chhabra, Anurag S. Rathore
Summary: In this study, chemometrics based analysis of Raman spectra was used for quantitative prediction of protein aggregation in lyophilized biotherapeutic products, demonstrating rapid and accurate assessment of protein aggregation level in samples. The proposed approach showed satisfactory performance with erythropoietin and human growth hormone.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Guusje van Schaick, Nadi el Hajjouti, Simone Nicolardi, Joost den Hartog, Romana Jansen, Rob van der Hoeven, Wim Bijleveld, Nicolas Abello, Manfred Wuhrer, Maurien M. A. Olsthoorn, Elena Dominguez-Vega
Summary: This study developed a workflow for the structural and functional characterization of endo-1,4-beta-xylanase (ENDO-I) and separated proteoforms using mass spectrometry and activity assays. It was found that the glycated species showed lower activity compared to the non-modified enzyme, providing guidance for product development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Alexandre Goyon, Brandon Scott, Christopher M. Crittenden, Kelly Zhang
Summary: A new comprehensive two-dimensional liquid chromatography method was developed to investigate oligomeric impurities in drugs. This method allowed for the separation of multiple oligomer species and identification of the root causes of oligomer impurities.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biophysics
Vincent Gauthier, Alice Lemarquand, Emmanuel Caplain, Nicolas Wilkie-Chancellier, Stephane Serfaty
Summary: In response to alternative non-animal testing, biosensors specifically designed for monitoring ex vivo skin explants present a challenge in studying physiological-like behavior and optimizing new topical products. The article introduces a proof-of-concept biosensor that couples a thickness shear-mode transducer with human skin explants, allowing for monitoring the viscoelastic properties of the skin. A mechanical model based on fractional calculus is used to extract complex shear modulus and microstructural evolutions. Preliminary results demonstrate the sensor's sensitivity in probing skin viscoelasticity in a life-like state and the effects of culture medium, as well as the identification of mechanical breaches in the skin barrier after the use of peeling products.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Electrical & Electronic
Vincent Gauthier, Emmanuel Caplain, Stephane Serfaty, Magalie Michiel, Pascal Griesmar, Nicolas Wilkie-Chancellier
Summary: This paper presents a multifrequency technique to investigate the evolution of soft matter at mesoscopic scale and its relationships with other scales. A TMS resonator is used as an ultrasonic microrheometer to measure mechanical impedance and monitor the effective viscosity and internal structure simultaneously. The technique is validated with different complex materials, and the extracted structural parameter can be linked to fractal dimension.
IEEE SENSORS JOURNAL
(2022)
Article
Anthropology
Jacopo La Nasa, Ilaria Degano, Francesca Modugno, Camilla Guerrini, Federica Facchetti, Valentina Turina, Andrea Carretta, Christian Greco, Enrico Ferraris, Maria Perla Colombini, Erika Ribechini
Summary: The burial assemblage of Kha and Merit discovered in 1906 and now preserved at the Museo Egizio constitutes the most abundant, complete, and well-preserved non-royal Egyptian burial assemblage ever found. A study shows that volatile compounds emitted by organic materials in vessels can be analyzed and detected directly in museums using a transportable mass spectrometer. This research proves the reliability of this method for archaeometric investigations in museums.
JOURNAL OF ARCHAEOLOGICAL SCIENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
Silvia Schoch, Dalila Iacopini, Maria Dalla Pozza, Sebastiano Di Pietro, Ilaria Degano, Gilles Gasser, Valeria Di Bussolo, Fabio Marchetti
Summary: In this study, glycoconjugated diiron complexes with mannose, glucose, and fructose moieties were synthesized and evaluated for their cytotoxicity against various cancer cell lines. The compounds showed significant stability in solution and cell culture medium, and did not exhibit appreciable selectivity towards cancer cells compared to non-tumor cells.
Article
Biochemical Research Methods
Camilla Guerrini, Federica Nardella, Annachiara Morganti, Jacopo La Nasa, Ilaria Degano, Erika Ribechini
Summary: The study uses nondestructive techniques to analyze resin types in archaeological artifacts using SIFT-MS. Through the establishment of a SIFT-MS mass spectra database and the use of PCA analysis, different classes of resins were successfully distinguished.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Engineering, Electrical & Electronic
Sylvain Castanet, Alexiane Pasquier, Thi-Hong Nhung Dinh, Hana Boukharouba, Stephane Serfaty, Pierre-Yves Joubert
Summary: The feasibility of using a high sensitivity radiofrequency (RF) passive resonator for non-contact assessment of fruit ripening by sensing fruit dielectric property changes was investigated. The results showed that the RF sensor could effectively monitor the ripening process of fruits, potentially leading to the development of a low-cost, non-destructive assessment method.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Biochemistry & Molecular Biology
Alice Lemarquand, Vincent Gauthier, Nicolas Wilkie-Chancellier, Stephane Serfaty
Summary: Investigating the mechanical properties of skin is important for monitoring changes in cutaneous barrier function. Skin is a complex tissue with viscoelastic properties. A biosensor with a thickness shear mode transducer (TSM) was used to characterize the mechanical properties of ex vivo skin. The biosensor was validated and a signature of the viscoelastic evolutions of different skin layers was identified. Monitoring was also conducted on stripped skin explants mimicking a weakened barrier function.
Article
Chemistry, Analytical
Francesca De Falco, Tommaso Nacci, Lee Durndell, Richard C. Thompson, Ilaria Degano, Francesca Modugno
Summary: Biodegradable polymers offer a potential solution to plastic pollution, but assessing their degradation process and chemical composition is crucial. This study used Py-GC-MS and EGA-MS techniques to analyze the thermal degradation profiles, main m/z ions, and pyrolysis markers of different biodegradable polymers and commercial products. The presence of additives and impurities was also identified. These findings contribute to a better understanding of the degradation process and chemical composition of biodegradable polymers in the environment.
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
(2023)
Article
Chemistry, Multidisciplinary
Andres Arciniegas, Loic Martinez, Stephane Serfaty, Nicolas Wilkie-Chancellier
Summary: Many museums have been producing reproductions to replace weakened artworks exhibited outdoors. French consortium Reunion des Musees Nationaux-Grand Palais works with composite materials to imitate the original aesthetic, however, these reproductions also age and deteriorate due to outdoor exposure. This study aims to analyze the resin/mineral powder composite materials used in cultural heritage reproduction and propose nondestructive evaluation techniques for monitoring the structural health of large-format artwork.
APPLIED SCIENCES-BASEL
(2023)
Article
Humanities, Multidisciplinary
Lucrezia Milillo, Marei Hacke, Sara Norrehed, Ilaria Degano, Francesca Gherardi, Ellinor Gunnarsson
Summary: This study is the first scientific research on khipu dyes and inorganic mordants and auxiliaries, providing a new approach to understanding the meaningful materiality, technology, and colours of khipus. Khipus are often described as Andean knotted records, but they are more than just complex knotted cords: a significant amount of encoded information resides in the incredible colours of khipus.
Editorial Material
Humanities, Multidisciplinary
Jo Kirby, Marei Hacke, Sara Norrehed, Joanne Dyer, Art Proano Gaibor, Ilaria Degano, Zvi Koren, Edith Sandstrom
Article
Humanities, Multidisciplinary
Francesca Sabatini, Jacopo La Nasa, Ilaria Degano, Beatrice Campanella, Stefano Legnaioli, Ilaria Saccani, Francesca Modugno, Marta Manso
Summary: In recent years, there has been a growing recognition of the social and cultural significance of street art murals, leading to a focus on preserving representative modern urban murals. The UBUNTU mural is an interesting case study, as it has undergone significant changes in appearance over a few years due to exposure to sunlight and environmental factors. Analysis of collected samples has revealed the painting materials used by the artist and the aging phenomena responsible for the fading colors of the mural.
Article
Polymer Science
Elisa Della Latta, Francesca Sabatini, Cosimo Micheletti, Marco Carlotti, Francesca Martini, Francesca Nardelli, Antonella Battisti, Ilaria Degano, Marco Geppi, Andrea Pucci, Svenja Pohl, Guido Kickelbick
Summary: In this study, flexible luminescent solar concentrators (LSCs) with a size of 5 x 5 cm(2) were prepared by integrating a reactive perylene bisimide fluorophore (FC546) into a polysiloxane network. The LSCs exhibited higher thermal and light stability, as well as superior device efficiency, compared to other similar-sized flexible LSC systems.
Article
Chemistry, Applied
Adele Ferretti, Ilaria Degano, Stefano Legnaioli, Beatrice Campanella, Aurora Sainati, Maria Perla Colombini
Summary: Throughout history, human beings have used writing as a means of communication and expression. This study focuses on the analysis of red inks produced in France during the late 19th to early 20th century. By utilizing various analytical techniques, the researchers were able to identify the dyes, pigments, binders, and additives used in these inks. The findings provide valuable insights into the early days of the synthetic dye industry.
Proceedings Paper
Engineering, Biomedical
Alexiane Pasquier, Yohan Le Diraison, Stephane Serfaty, Pierre-Yves Joubert
Summary: The dielectric properties of tissues play a significant role in detecting and monitoring pathologies. This paper proposes the use of TLR sensors to non-invasively sense changes in organic tissues and monitor their dielectric properties. Experimental results demonstrate the ability of TLR sensors to detect and discriminate between different soft matter samples. Multi-frequency investigation also enhances tissue characterization. TLR sensors are therefore promising for non-invasive, low-cost, and sensitive monitoring of pathologies.
2022 IEEE INTERNATIONAL SYMPOSIUM ON MEDICAL MEASUREMENTS AND APPLICATIONS (MEMEA 2022)
(2022)
Article
Chemistry, Analytical
Michel Rocha Baqueta, Augusto Cesar Costa-Santos, Ana Paula Rebellato, Gisele Marcondes Luz, Juliana Azevedo Lima Pallone, Federico Marini, Alexsandro Lara Teixeira, Douglas N. Rutledge, Patricia Valderrama
Summary: This study reports the essential element composition of new Brazilian Canephora coffees and applies chemometric tools for analysis. The results demonstrate the suitability of this method for origin and species discrimination based on the inorganic fraction of coffee.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mengjie Li, Jiapeng Wang, You Zhou, Yang Chen, Lingying Xia
Summary: A novel photoelectrochemical biosensor based on gold nanoparticles and specific structures was developed for highly sensitive detection of mercury ion. The multiple sandwich structures hindered electron supply and light harvesting, resulting in a weakened PEC signal, while the specific structures extinguished the PEC signal, enabling quantitative detection of Hg2+. The sensor exhibited high selectivity and stability, with potential applications in environmental detection, biological analysis, and medical research.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mohamed A. Korany, Rasha M. Youssef, Marwa A. A. Ragab, Mostafa A. Afify
Summary: A stability-indicating fit-for-purpose method was developed for the determination of HC, TL, and PS in syrup dosage form. The method successfully separated CL from THY and quantified the analytes using HPLC-DAD. The robustness of the method was assessed through statistical analysis and self-validation.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Lingling Lin, Minyu Li, Ping Li, Chenqing Ye, Huanglong Zhuang, Shaohuang Weng, Feng Chen
Summary: This study developed a highly sensitive and selective electrochemical sensor for simultaneous detection of dopamine and uric acid. The sensor exhibited excellent anti-interference and stability, and could accurately measure dopamine and uric acid in human urine samples.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma
Summary: In this study, a high-performance SERS-active aptasensor was successfully developed for the quantitative analysis of AFB1 in cereal grains, which is of great significance in the field of food safety.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
E. Abas, C. Marina-Montes, C. Perez-Marin, J. Puimedon, J. Anzano
Summary: This study conducted a comprehensive measurement of natural and anthropogenic radionuclides in soil, water, and air in different locations around Deception Island in Antarctica. The results revealed significant levels of 210Pb and anthropogenic 137Cs in soil samples near old human settlements and facilities, as well as detectable levels of 137Cs and 60Co in water samples from old hunting areas. The findings also suggested potential resuspension processes based on higher-than-expected air quality results.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Joao Franciso Allochio, Nayara A. dos Santos, Nathalia dos S. Conceicao, Clara S. D. Baptista, Keyller B. Borges, Valdemar Lacerda Jr, Wanderson Roma
Summary: This study developed a fiber spray ionization mass spectrometry (FSI-MS) method, which shows great potential in detecting illicit drugs. Compared with paper spray ionization mass spectrometry (PSI-MS), FSI-MS demonstrates higher sensitivity in COC detection.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Dina A. Ahmed, Ola G. Hussein, Mamdouh R. Rezk, Mohamed Abdelkawy, Yasmin Rostom
Summary: The main goal of this study was to develop two green chromatographic techniques, HPLC and TLC, for the determination of alcaftadine (ALF) in pharmaceutical formulation and biological samples. The developed HPLC technique showed high efficiency and minimal environmental impact, successfully identifying ALF in the presence of its degradate. The TLC method provided a stability indicating study for ALF and was determined to be safe, green, and eco-friendly.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Abdullah Taner Bisgin
Summary: A green, speedy, and handy method for separation and determination of four commonly used food colorants was established using vortex assisted sequential-simultaneous liquid phase micro-extraction (VA-SS-LPME). The method does not require any instrumental chromatographic techniques. The procedure includes sequential separation steps using different extractants and simultaneous UV-vis spectrophotometric determination steps. The method is environmentally friendly and applicable for determination of colorants in food and pharmaceuticals.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Yifan Zhang, Tong Zhang, Wenjing Ba, Li Liu, Yuan Rao, Xiaodan Zhang, Hanhan Zhang, Xiu Jin
Summary: This paper proposes a novel spectral transfer modelling method based on neural network architecture searching for the asymptomatic prediction of Akizuki pear cork spot disorder. The experiments show that the model by this method is more effective, achieving an accuracy of 82.61%.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: For the first time, a dispersive micro-solid phase extraction (D-mu SPE) based on graphene oxide was used for the ultrasensitive determination of Cd. With this method, Cd can be efficiently extracted from a mixture of alkali and alkaline earth metals without the need for an elution step. The combination of D-mu SPE and SAGD OES significantly reduces matrix effects and improves the tolerance of Cd to alkali metals. The method shows simplicity in the measurement system and the commercially available nanosorbent used.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
P. K. Fathima Anjila, G. R. Tharani, Anand Sundaramoorthy, Venkat Kumar Shanmugam, Karthikeyan Subramani, Shanmugavel Chinnathambi, Ganesh N. Pandian, Vimala Raghavan, Andrews Nirmala Grace, Singaravelu Ganesan, Mangaiyarkarasi Rajendiran
Summary: This work proposes a rapid and sensitive spectroscopic method for detecting melamine in food products using rare-earth Terbium-doped Graphene Quantum Dots (Tb-GQDs) synthesized by microwave and simple chemical conjugation methods. The synthesized Tb-GQDs show a spherical shape with a size of approximately 6 nm and a quantum yield of 52%. The maximum detection limit for melamine concentration in milk and milk products is found to be 0.31 μM. The dual emitting Tb-GQDs provide a sensitive and effective platform for real-time detection of melamine in food samples, particularly in milk, and show promising potential in the food industry.
MICROCHEMICAL JOURNAL
(2024)
Review
Chemistry, Analytical
Piyush Dey, Mandeep Kaur, Akhil Khajuria, Dilmeet Kaur, Manpreet Singh, Hema Kumari Alajangi, Neha Singla, Gurpal Singh, Ravi Pratap Barnwal
Summary: Environmental issues, such as the uncontrolled release of dangerous pollutants, have significant impacts on human health. Traditional methods for detecting pollutants require specialized personnel and equipment, but nanotechnology has improved the performance of biosensors. This article discusses the use of nanotechnology in pollutant detection and the associated techniques.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Sa Dong, Qiuyun Shi, Lingjun Guan, Yulong Wang, Pengyan Liu, Cunzheng Zhang, Jianguo Feng
Summary: In this study, a highly sensitive indirect competitive chemiluminescence enzyme immunoassay (icCLEIA) method was developed for the determination of sodium pentachlorophenolate (PCP-Na) and its metabolite pentachlorophenol (PCP). The method showed high specificity and affinity with a detection limit of 0.0032 ng/mL for PCP-Na and 0.0192 ng/mL for PCP. The method had no cross reaction with other chlorophenols compounds except for PCP. The average recoveries in chicken, pork and fish samples were 81.3-105.8% with low coefficient of variation (CV).
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Palaniappan Ilayaraja, Murugan Manivannan, Paramasivam Parthiban
Summary: Nirmatrelvir, an antiviral drug used for the treatment of COVID-19, has been recommended by the World Health Organization. We developed an optimized analytical method for the quantification of Nirmatrelvir and its products, with high sensitivity and a wide linear range. The method also meets the requirements for greenness evaluation.
MICROCHEMICAL JOURNAL
(2024)
