Article
Immunology
Yimei Que, Huimin Li, Liman Lin, Xiaojian Zhu, Min Xiao, Ying Wang, Li Zhu, Dengju Li
Summary: DNMT3A mutation in AML leads to immune escape, inhibition of M1 macrophage polarization, resistance to its killing effect, increased tumor volume, and promotion of M2 macrophage proportion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Qiong Ning, Tianzi Jian, Siqi Cui, Longke Shi, Xiangdong Jian, Xiaopeng He, Xiangxing Zhang, Xiangxin Li
Summary: This study reveals the crucial role of Tim-3 and macrophage polarization in benzene-induced acute myeloid leukemia (AML). Benzene exposure upregulates Tim-3 expression and promotes the generation of M2-type macrophages, as well as alters cytokine secretion. These findings provide a new potential intervention site for immune checkpoint-based AML therapeutic strategy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Jiaqi Wu, Xiaoyu Ma, Yu Lu, Tao Zhang, Zuoqin Du, Jin Xu, Jingcan You, Ni Chen, Xin Deng, Jianbo Wu
Summary: Pueraria lobata exerts anti-inflammatory effects through the activation of exosomes and shifts in macrophage polarization.
Article
Environmental Sciences
Bo Ma, Jun Wang, Paheredini Yusufu
Summary: This study investigated the role of exosome ELFN1-AS1 in gastric cancer by examining its expression and interactions with miR-4644 and PKM. The results showed that ELFN1-AS1 was upregulated in GC tissue and cells, with high enrichment in exosomes. Exosomal ELFN1-AS1 enhanced the cell abilities and stemness of GC, modulated glycolysis via PKM, and promoted M2 polarization and macrophage recruitment. In vivo experiments further confirmed that exosomal ELFN1-AS1 enhanced GC cell growth, metastasis, and M2 polarization.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Yang Xiao, Jinghong Chen, Jia Wang, Wei Guan, Mengzhen Wang, Linlin Zhang, Zhiding Wang, Lixin Wang, Li Yu
Summary: In patients with AML, the expression of ICAM-1 is silenced, but the hypomethylating agent can upregulate its expression, facilitating NK cells to kill AML cells. High expression of ICAM-1 can reverse AML immune evasion and activate NK cell function, suggesting a new strategy for AML treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Lisa E. Emerson, Anna Gioseffi, Hailey Barker, Austin Sheppe, Julianne K. Morrill, Mariola J. Edelmann, Peter Epeh Kima
Summary: This study demonstrates that macrophages release extracellular vesicles (EVs) containing parasite-derived molecules during Leishmania infection and bacterial-derived molecules during Salmonella Typhimurium infection. These EVs can be distributed in infected tissues and taken up by liver cells. The EVs produced during Leishmania infection induce gene expression consistent with M2 polarization in macrophages, while the EVs produced during Salmonella Typhimurium infection stimulate gene expression associated with M1 polarization.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Yuncheng Tang, Sheng Hu, Tian Li, Xiaofeng Qiu
Summary: Colorectal cancer (CRC) is a common tumor with significant mortality worldwide. Tumor-associated macrophages (TAMs) play a critical role in promoting tumor incidence and progression. However, the mechanism of interaction between CRC cells and TAMs polarization is still being investigated.
Article
Gastroenterology & Hepatology
Yuting Zhang, Jiakun Guo, Liyin Zhang, Ying Li, Kangliang Sheng, Yawei Zhang, Liu Liu, Wenbin Gong, Kun Guo
Summary: This study found that circASPH is upregulated in colorectal cancer (CRC) and enhances M2 macrophage polarization through exosomal STING, thereby accelerating CRC progression. These findings support circASPH as a promising therapeutic target for CRC treatment.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Jiahui Gu, Shengrui Yang, Xueying Wang, Yining Wu, Jia Wei, Jian Xu
Summary: This study aimed to investigate the effects of hypoxic lung adenocarcinoma (LUAD)-derived exosomes on macrophage polarization and explore the underlying molecular mechanism. It was found that hypoxic LUAD cells released exosomes enriched with miR-1290, which could be transferred to macrophages. Overexpression of miR-1290 induced macrophage polarization into an M2 phenotype. Exosomal miR-1290 targeted the downstream gene SOCS3 to activate the STAT3 signaling pathway, promoting M2 macrophage polarization. Targeting exosomal miR-1290 may provide a potential immunotherapeutic strategy for LUAD.
Article
Multidisciplinary Sciences
Baisui Feng, Lingzhi Xu, Shuo Song, Huazhen Liu, Yan Li, Suqin Hu, Qing Shu, Jiangqi Liu, Zhiqiang Liu, Haiqiong Yu, Pingchang Yang
Summary: The impaired immune regulatory function of M4 cells obtained from UC patient colon lavage fluid (CLF) was characterized in this study. M4s were the most abundant cellular components in CLF (21.3 4.0%). The M2 M4s (M2 cells) from the ulcerative colitis (UC) group showed weaker immune suppressive function and lower abundance. High levels of endoplasmic reticulum (ER) stress associated molecules were detected in UC M2 cells. XBP1 promoted the expression of Rnf20 in M2 cells. Rnf20 reduced PD-L1 abundance in UC M2 cells and impaired the immune suppressive ability. Inhibition of Rnf20 restored the immune regulating capacity of M2 cells and suppressed experimental colitis.
Article
Pharmacology & Pharmacy
Chong Lu, Wei Shi, Wenjing Hu, Yu Zhao, Xiangwang Zhao, Fang Dong, Yue Xin, Tao Peng, Chunping Liu
Summary: This study found that circ_0001142 is highly expressed in breast cancer and plays an important role in regulating macrophage polarization. Additionally, the ER pathway promotes the entry of circ_0001142 into macrophages and interferes with its function.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Bahman Razi, Masoud Soleimani, Mina Soufi-Zomorrod, Ahmad Adeli, Noushin Davoudi
Summary: It has long been speculated that leukemic cells can influence resident cells in the tumor microenvironment to promote tumor development. Exosomes, specifically those derived from multiple myeloma cells, have been shown to affect the polarization of macrophages towards M2-like cells. This leads to changes in gene expression, immunophenotyping markers, cytokine secretion, and intracellular signaling in macrophages.
Article
Biochemistry & Molecular Biology
Juan Cai, Lin Huang, Hongri Tang, Hongling Xu, Lingjun Wang, Minghui Zheng, Hongsong Yu, Hui Liu
Summary: The MIF produced by Thelazia callipaeda can induce M2-like macrophage polarization through TLR4-mediated activation of the PI3K-Akt pathway, potentially aiding in disrupting the host immune system.
Article
Chemistry, Multidisciplinary
Xiaotu Ma, Meinan Yao, Yu Gao, Yale Yue, Yao Li, Tianjiao Zhang, Guangjun Nie, Xiao Zhao, Xiaolong Liang
Summary: Immune cell-derived exosomes have been engineered as radiotherapy sensitizers in order to enhance the efficacy of radiotherapy by modifying the immune microenvironment and increasing DNA damage repair inhibition.
Article
Immunology
De-sheng Tang, Feng Cao, Chang-sheng Yan, Ji-tao Cui, Xiao-yu Guo, Long Cheng, Le Li, Yi-long Li, Jia-min Ma, Kun Fang, Lei Gao, Nian-sheng Ren, Bei Sun, Gang Wang, Liang Ji
Summary: Acinar cell-derived extracellular vesicles (EVs), especially EV miR-183-5p, play an important role in the crosstalk between acinar cells and macrophages in the development of acute pancreatitis (AP). EV miR-183-5p induces M1 macrophage polarization and reduces macrophage phagocytosis by downregulating FoxO1. The elevated levels of EV miR-183-5p in clinical samples are positively correlated with the severity of AP.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)