Role of dihydrofolate reductase in tetrahydrobiopterin biosynthesis and lipid metabolism in the oleaginous fungus Mortierella alpina

Characterization of an fungal l-fucokinase involved inMortierella alpinaGDP-l-fucose salvage pathway

(2016) Hongchao Wang et al.   GLYCOBIOLOGY

Identification of a critical determinant that enables efficient fatty acid synthesis in oleaginous fungi

(2015) Haiqin Chen et al.   Scientific Reports

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

(2014) Roland Nilsson et al.   Nature Communications

Role of the Phenylalanine-Hydroxylating System in Aromatic Substance Degradation and Lipid Metabolism in the Oleaginous Fungus Mortierella alpina

(2013) Hongchao Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans

(2013) C. T. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of Candida albicans Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal the Flexibility of Active Site Loop Residues Critical for Ligand Potency and Selectivity

(2011) Janet L. Paulsen et al.   Chemical Biology & Drug Design

Biochemical characterization of the tetrahydrobiopterin synthesis pathway in the oleaginous fungus Mortierella alpina

(2011) H. Wang et al.   MICROBIOLOGY-SGM

Genome Characterization of the Oleaginous Fungus Mortierella alpina

(2011) Lei Wang et al.   PLoS One

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Improved production of various polyunsaturated fatty acids through filamentous fungus Mortierella alpina breeding

(2009) Eiji Sakuradani et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling

(2009) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Guided Development of Efficacious Antifungal Agents Targeting Candida glabrata Dihydrofolate Reductase

(2008) Jieying Liu et al.   CHEMISTRY & BIOLOGY

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS