Preclinical screen for protection efficacy of chlamydial antigens that are immunogenic in humans

Prophylactic and therapeutic vaccination protects sperm health from Chlamydia muridarum-induced abnormalities

(2023) Emily R Bryan et al.   BIOLOGY OF REPRODUCTION

Induction of Transmucosal Protection by Oral Vaccination with an Attenuated Chlamydia

(2023) Yihui Wang et al.   INFECTION AND IMMUNITY

Genital tract microbiome dynamics are associated with time of Chlamydia infection in mice

(2023) Lihong Zhao et al.   Scientific Reports

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters

(2023) Geraldine Nouailles et al.   Nature Microbiology

Chlamydia deficient in plasmid-encoded glycoprotein 3 (pGP3) as an attenuated live oral vaccine

(2022) Zengzi Zhou et al.   INFECTION AND IMMUNITY

Evidence for cGAS-STING Signaling in the Female Genital Tract Resistance to Chlamydia trachomatis Infection

(2022) Xin Su et al.   INFECTION AND IMMUNITY

Effectiveness of a serogroup B outer membrane vesicle meningococcal vaccine against gonorrhoea: a retrospective observational study

(2022) Winston E Abara et al.   LANCET INFECTIOUS DISEASES

Review of use of inactivated poliovirus vaccine in campaigns to control type 2 circulating vaccine derived poliovirus (cVDPV) outbreaks

(2022) Concepcion F. Estivariz et al.   VACCINE

Epitope-Based Vaccines against the Chlamydia trachomatis Major Outer Membrane Protein Variable Domain 4 Elicit Protection in Mice

(2022) Amanda L. Collar et al.   Vaccines

An Overview of Vaccine Adjuvants: Current Evidence and Future Perspectives

(2022) Alessio Facciolà et al.   Vaccines

Chlamydia trachomatis vaccine development – a view on the current challenges and how to move forward

(2022) Álvaro H. Borges et al.   Expert Review of Vaccines

The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine

(2021) Junli Li et al.   npj Vaccines

Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?

(2021) Luis M. de la Maza et al.   Expert Review of Vaccines

Licensed Bacille Calmette-Guérin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation

(2020) Asimenia Angelidou et al.   VACCINE

Incomplete Freund’s adjuvant reduces arginase and enhances Th1 dominance, TLR signaling and CD40 ligand expression in the vaccine site microenvironment

(2020) Karlyn E Pollack et al.   Journal for ImmunoTherapy of Cancer

The 1B vaccine strain of Chlamydia abortus produces placental pathology indistinguishable from a wild type infection

(2020) Sergio Gaston Caspe et al.   PLoS One

The plasmid-encoded pGP3 promotes Chlamydia evasion of acidic barriers in both stomach and vagina

(2019) Tianyuan Zhang et al.   INFECTION AND IMMUNITY

Distinct Roles of Chromosome- versus Plasmid-Encoded Genital Tract Virulence Factors in Promoting Chlamydia muridarum Colonization in the Gastrointestinal Tract

(2019) John J. Koprivsek et al.   INFECTION AND IMMUNITY

Safety and immunogenicity of the chlamydia vaccine candidate CTH522 adjuvanted with CAF01 liposomes or aluminium hydroxide: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial

(2019) Sonya Abraham et al.   LANCET INFECTIOUS DISEASES

Evasion of Innate Lymphoid Cell-Regulated Gamma Interferon Responses by Chlamydia muridarum To Achieve Long-Lasting Colonization in Mouse Colon

(2019) John J. Koprivsek et al.   INFECTION AND IMMUNITY

Oral Chlamydia vaccination induces transmucosal protection in the airway

(2018) Cuiming Zhu et al.   VACCINE

Genomic evidence that the live Chlamydia abortus vaccine strain 1B is not attenuated and has the potential to cause disease

(2018) David Longbottom et al.   VACCINE

Rectal administration of a chlamydial subunit vaccine protects against genital infection and upper reproductive tract pathology in mice

(2017) Roshan Pais et al.   PLoS One

Chlamydial Plasmid-Dependent Pathogenicity

(2017) Guangming Zhong   TRENDS IN MICROBIOLOGY

National Institute of Allergy and Infectious Diseases workshop report: “Chlamydia vaccines: The way forward”

(2017) Guangming Zhong et al.   VACCINE

The Chlamydia-Secreted Protease CPAF Promotes Chlamydial Survival in the Mouse Lower Genital Tract

(2016) Zhangsheng Yang et al.   INFECTION AND IMMUNITY

A working model for the type III secretion mechanism in Chlamydia

(2016) Joshua C. Ferrell et al.   MICROBES AND INFECTION

A re-evaluation of the role of B cells in protective immunity to Chlamydia infection

(2015) Lin-Xi Li et al.   IMMUNOLOGY LETTERS

The Chromosome-Encoded Hypothetical Protein TC0668 Is an Upper Genital Tract Pathogenicity Factor of Chlamydia muridarum

(2015) Turner Allen Conrad et al.   INFECTION AND IMMUNITY

Chlamydia muridarum Induction of Glandular Duct Dilation in Mice

(2015) Xin Sun et al.   INFECTION AND IMMUNITY

In VitroPassage Selects for Chlamydia muridarum with Enhanced Infectivity in Cultured Cells but Attenuated Pathogenicity in Mouse Upper Genital Tract

(2015) Chaoqun Chen et al.   INFECTION AND IMMUNITY

A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells

(2015) G. Stary et al.   SCIENCE

Vibrio cholerae ghosts (VCG) exert immunomodulatory effect on dendritic cells for enhanced antigen presentation and induction of protective immunity

(2014) Francis O Eko et al.   BMC IMMUNOLOGY

Plasmid-Encoded Pgp3 Is a Major Virulence Factor for Chlamydia muridarum To Induce Hydrosalpinx in Mice

(2014) Yuanjun Liu et al.   INFECTION AND IMMUNITY

Novel Chlamydia muridarum T Cell Antigens Induce Protective Immunity against Lung and Genital Tract Infection in Murine Models

(2014) H. Yu et al.   JOURNAL OF IMMUNOLOGY

Chlamydial Induction of Hydrosalpinx in 11 Strains of Mice Reveals Multiple Host Mechanisms for Preventing Upper Genital Tract Pathology

(2014) Jianlin Chen et al.   PLoS One

Structure of theChlamydia trachomatisImmunodominant Antigen Pgp3

(2013) Ahmad Galaleldeen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

(2013) J. R. Barker et al.   mBio

Chlamydia muridarum T Cell Antigens and Adjuvants That Induce Protective Immunity in Mice

(2012) Hong Yu et al.   INFECTION AND IMMUNITY

Chlamydia trachomatis Outer Membrane Complex Protein B (OmcB) Is Processed by the Protease CPAF

(2012) S. Hou et al.   JOURNAL OF BACTERIOLOGY

Chlamydia trachomatis Antigens Recognized in Women With Tubal Factor Infertility, Normal Fertility, and Acute Infection

(2012) Nicole M. Budrys et al.   OBSTETRICS AND GYNECOLOGY

Genome-wide identification of Chlamydia trachomatis antigens associated with tubal factor infertility

(2011) Allison K. Rodgers et al.   FERTILITY AND STERILITY

A Chlamydia trachomatis OmcB C-Terminal Fragment Is Released into the Host Cell Cytoplasm and Is Immunogenic in Humans

(2011) Manli Qi et al.   INFECTION AND IMMUNITY

Chlamydia trachomatis Secretion of an Immunodominant Hypothetical Protein (CT795) into Host Cell Cytoplasm

(2011) M. Qi et al.   JOURNAL OF BACTERIOLOGY

A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates

(2011) Laszlo Kari et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunization with Live and Dead Chlamydia muridarum Induces Different Levels of Protective Immunity in a Murine Genital Tract Model: Correlation with MHC Class II Peptide Presentation and Multifunctional Th1 Cells

(2011) H. Yu et al.   JOURNAL OF IMMUNOLOGY

Chlamydia trachomatis secretion of hypothetical protein CT622 into host cell cytoplasm via a secretion pathway that can be inhibited by the type III secretion system inhibitor compound 1

(2011) S. Gong et al.   MICROBIOLOGY-SGM

Vaccination with the defined chlamydial secreted protein CPAF induces robust protection against female infertility following repeated genital chlamydial challenge

(2011) Ashlesh K. Murthy et al.   VACCINE

Evaluation of a broadly protective Chlamydia–cholera combination vaccine candidate

(2011) F.O. Eko et al.   VACCINE

Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection

(2011) Tyler H.T. Brown et al.   VACCINE

Protective immunity against mouse upper genital tract pathology correlates with high IFNγ but low IL-17 T cell and anti-secretion protein antibody responses induced by replicating chlamydial organisms in the airway

(2011) Chunxue Lu et al.   VACCINE

Chlamydia Trachomatis Secretion of Proteases for Manipulating Host Signaling Pathways

(2011) Guangming Zhong   Frontiers in Microbiology

Chlamydia muridarum T-Cell Antigens Formulated with the Adjuvant DDA/TDB Induce Immunity against Infection That Correlates with a High Frequency of Gamma Interferon (IFN- )/Tumor Necrosis Factor Alpha and IFN- /Interleukin-17 Double-Positive CD4+ T Cells

(2010) H. Yu et al.   INFECTION AND IMMUNITY

Characterization of Pgp3, a Chlamydia trachomatis Plasmid-Encoded Immunodominant Antigen

(2010) D. Chen et al.   JOURNAL OF BACTERIOLOGY

Mice Deficient in MyD88 Develop a Th2-Dominant Response and Severe Pathology in the Upper Genital Tract following Chlamydia muridarum Infection

(2010) Lili Chen et al.   JOURNAL OF IMMUNOLOGY

A Genome-Wide Profiling of the Humoral Immune Response to Chlamydia trachomatis Infection Reveals Vaccine Candidate Antigens Expressed in Humans

(2010) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Protection against Chlamydia Promoted by a Subunit Vaccine (CTH1) Compared with a Primary Intranasal Infection in a Mouse Genital Challenge Model

(2010) Anja Weinreich Olsen et al.   PLoS One

Chlamydia vaccine candidates and tools for chlamydial antigen discovery

(2009) Daniel D Rockey et al.   Expert Review of Vaccines

Genomic Analysis of an Attenuated Chlamydia abortus Live Vaccine Strain Reveals Defects in Central Metabolism and Surface Proteins

(2009) L. S. Burall et al.   INFECTION AND IMMUNITY

Chlamydia trachomatis Native Major Outer Membrane Protein Induces Partial Protection in Nonhuman Primates: Implication for a Trachoma Transmission-Blocking Vaccine

(2009) L. Kari et al.   JOURNAL OF IMMUNOLOGY

Killing me softly: chlamydial use of proteolysis for evading host defenses

(2009) Guangming Zhong   TRENDS IN MICROBIOLOGY

Chlamydia effector proteins and new insights into chlamydial cellular microbiology

(2008) Raphael H Valdivia   CURRENT OPINION IN MICROBIOLOGY

AVibrio choleraeghost-based subunit vaccine induces cross-protective chlamydial immunity that is enhanced by CTA2B, the nontoxic derivative of cholera toxin

(2008) Eno E. Ekong et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The Chlamydial Plasmid-Encoded Protein pgp3 Is Secreted into the Cytosol of Chlamydia-Infected Cells

(2008) Z. Li et al.   INFECTION AND IMMUNITY