Article
Biochemistry & Molecular Biology
Alma Lucia Villela Zumaya, Silvie Rimpelova, Marketa Stejdirova, Pavel Ulbrich, Jarmila Vilcakova, Fatima Hassouna
Summary: In this study, anti-CD133 monoclonal antibody-conjugated PLGA nanocarriers were designed and synthesized for targeted delivery of oxaliplatin and superparamagnetic nanoparticles to colorectal cancer cells. The results showed that non-PEGylated PLGA nanoparticles were more convenient for controlled drug release, while PEGylated PLGA nanoparticles had faster release kinetics. Additionally, the nanoparticles exhibited superparamagnetic behavior without magnetic hysteresis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Multidisciplinary
Mona Ebadi, Kalaivani Buskaran, Saifullah Bullo, Mohd Zobir Hussein, Sharida Fakurazi, Giorgia Pastorin
Summary: The study systematically investigated the structural, physicochemical, morphological, and magnetic properties of magnetic drug nanoparticles and their potential in cancer treatment. The coated Fe3O4 magnetite nanoparticles were found to be more effective than sorafenib alone against liver cancer cells, while displaying no cytotoxicity against fibroblasts. These results suggest that the coated Fe3O4 nanoparticles could be a promising drug delivery carrier for biomedical applications.
ALEXANDRIA ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Adriana Zelenakova, Jaroslava Szucsova, Lubos Nagy, Vladimir Girman, Vladimir Zelenak, Veronika Huntosova
Summary: In this study, a drug delivery composite (DDC) consisting of ordered mesoporous silica, iron oxide magnetic nanoparticles (Fe2O3), and the drug naproxen (Napro) was prepared. The results reveal the suppression of the Brownian relaxation process and indicate the potential application of the composite as a drug nanocarrier for magnetic-targeted drug delivery.
Article
Materials Science, Biomaterials
Niping Deng, Jinghang Li, Hao Lyu, Ruochuan Huang, Haoran Liu, Chengchen Guo
Summary: This study fabricates protein-based soft actuators with magnetic responsiveness using naturally occurring silk proteins and synthesized Fe3O4 magnetic nanoparticles. The results show that the soft actuators have good stretchability, mechanical properties matching soft tissues, degradability, biocompatibility, and in vivo X-ray visibility. The soft actuators can be actuated and used for localized drug delivery by attaching a magnet. These degradable silk-based soft actuators provide significant opportunities for improving current therapeutic strategies in biomedicine.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Pharmacology & Pharmacy
Yiling Wang, Yan Yang, Xi Zheng, Jianyou Shi, Lei Zhong, Xingmei Duan, Yuxuan Zhu
Summary: Leukemia is a malignancy caused by uncontrolled proliferation of hematopoietic stem cells, leading to destruction of the hematopoietic system. Traditional leukemia treatments have severe side effects due to the lack of specificity of anti-leukemic drugs. Nanotechnology, specifically iron oxide nanoparticles, has shown great potential in the diagnosis and treatment of leukemia. This review discusses the current approaches of using iron oxide nanoparticles for leukemia detection and treatment, highlighting their advantages in magnetic resonance imaging (MRI) detection, magnetic biosensors, and targeted drug delivery. The application of iron oxide nanoparticles in combination therapy for leukemia is also briefly discussed. Finally, the limitations of current applications of iron-based nanoparticles in leukemia diagnosis and treatment are addressed.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Calina Ciont, Amalia Mesaros, Oana Lelia Pop, Dan Cristian Vodnar
Summary: This study aims to investigate the interaction between iron oxide nanoparticles (IONPs) and probiotic cells and their impact on iron absorption, bioavailability, and microbiota variation. Through literature research and synthesis, the authors utilized a rigorous search methodology and collected 122 relevant research articles. The results showed that probiotics carrying IONPs had better treatment efficacy compared to conventional methods.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Roxana Cristina Popescu, Diana Iulia Savu, Miriam Bierbaum, Adriana Grbenicek, Frank Schneider, Hiltraud Hosser, Bogdan Stefan Vasile, Ecaterina Andronescu, Frederik Wenz, Frank A. Giordano, Carsten Herskind, Marlon R. Veldwijk
Summary: The study demonstrated that polyethylene glycol-encapsulated iron oxide nanoparticles showed potential for enhancing the intracellular delivery of a chemotherapeutic drug to improve the cytotoxic effects of ionizing radiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Dandan Kou, Yun Gao, Cang Li, Dandan Zhou, Kuan Lu, Ning Wang, Ruru Zhang, Zhe Yang, Yi Zhou, Lei Chen, Jianxian Ge, Jianfeng Zeng, Mingyuan Gao
Summary: The delivery and elimination pathways of intranasally administered nanodrugs were investigated using a PEGylated Fe3O4 nanoparticle labeled with a fluorescent dye. The distribution and elimination of the nanoparticles in the brain were studied through magnetic resonance imaging and fluorescence imaging, providing important insights for therapeutic applications of CNS drugs.
Article
Chemistry, Multidisciplinary
Peng Guo, Sara Busatto, Jing Huang, Golnaz Morad, Marsha A. Moses
Summary: The developed magnetic extrusion method offers a facile and scaled-up approach for preparing exosome mimetics (EMs) with similar properties and functions as native exosomes, overcoming manufacturing challenges. Additionally, engineered EMs demonstrate efficient drug delivery capabilities and tumor growth inhibition, showing promise as a biological nanomedicine for cancer drug delivery.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Deevak Ramnandan, Seipati Mokhosi, Aliscia Daniels, Moganavelli Singh
Summary: Cancer-based magnetic theranostics using MgFe2O4 ferrite MNPs functionalized with polymers show promising potential for enhancing drug delivery and effective treatment of cancer. DOX-CHI-MNPs exhibit superior anticancer activity and pH-responsive drug release, indicating their potential in cancer therapy.
Article
Multidisciplinary Sciences
Zhi-Hao Wang, Mengyu Chu, Na Yin, Wanting Huang, Wei Liu, Zhenzhong Zhang, Junjie Liu, Jinjin Shi
Summary: This study presents a biological chemotaxis-guided self-thermophoretic nanoplatform that improves the efficacy of oral drug delivery systems for colorectal cancer treatment. The nanoplatform achieves precise intestinal positioning and autonomous mucus penetration by introducing platinum-sprayed mesoporous silica and camouflaging with Staphylococcus aureus membrane. The nanoplatform significantly enhances the oral bioavailability of cisplatin and exhibits a high tumor inhibition rate in CRC-bearing mice.
Article
Biochemistry & Molecular Biology
Seyedeh-Maryam Hasheminya, Jalal Dehghannya, Ali Ehsani
Summary: The effect of zinc oxide nanoparticles on basil seed mucilage-polyvinyl alcohol films was investigated. The concentration of nanoparticles influenced the moisture content, solubility, permeability, mechanical properties, color, light transmission, and antibacterial and antifungal activities of the films.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Jae-pil Jeong, Kyungho Kim, Jaeyul Kim, Yohan Kim, Seunho Jung
Summary: In this study, new hydrogels were fabricated using polyvinyl alcohol (PVA) and succinoglycan (SG) obtained from Sinorhizobium meliloti Rm 1021. The hydrogel composition and freeze-thaw cycles were optimized to enhance the swelling ratio. The optimized hydrogel exhibited pH-responsive drug release and was non-toxic and biocompatible, making it a potential candidate for chronic wound dressing applications.
Article
Biochemistry & Molecular Biology
R. Shiji, Manu M. Joseph, Anitha Sen, K. Raveendran Pillai, Bs Unnikrishnan, T. T. Sreelekha
Summary: This study modified superparamagnetic iron oxide nanoparticles (SPIONs) using an eco-friendly substance extracted from pomegranate fruit peel, which resulted in tumor-targeted accumulation and improved biocompatibility. By attaching an anticancer drug to the modified nanoparticles, the drug could be selectively released in tumor cells, leading to improved tumor reduction and survival benefits. The modified nanoparticles also exhibited remarkable contrast in magnetic resonance imaging (MRI) for targeted tumor therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Kheireddine El-Boubbou, Rizwan Ali, Sulaiman Al-Humaid, Alshaimaa Alhallaj, O. M. Lemine, Mohamed Boudjelal, Abdulmohsen AlKushi
Summary: This work focuses on the fabrication and characterization of iron oxide mesoporous magnetic nanostructures (IO-MMNs), which showed high surface areas, large pore volumes, small sizes, good crystallinity, and biocompatibility. The drug-loaded IO-MMNs demonstrated significant inhibition of breast and colon cancer cells with minimal toxicity towards normal cells. These results suggest the potential use of IO-MMNs as effective drug delivery agents in cancer theranostics.