Article
Agriculture, Dairy & Animal Science
Mahmoud M. Abouelfetouh, Eman Salah, Lingling Liu, Ahmed H. Khalil, Qiulin Zhang, Mingxing Ding, Yi Ding
Summary: Goats have been used as animal models in research, and the need for achieving safer anesthesia for research or surgical intervention is gaining much attention. This study aimed to evaluate the intraoperative effects and immediate postoperative pain control of a nalbuphine-ketamine regimen in goats. The results showed that the combination of nalbuphine and ketamine provided better induction of anesthesia and recovery compared to ketamine alone, and it also produced better postoperative pain control.
Article
Multidisciplinary Sciences
Zhiheng Zhang, Hui Bai, Bo Zhang, Meilun Shen, Li Gao
Summary: This study evaluated the cardiorespiratory and anesthetic effects of KMXS and TZX as general anesthetics in miniature pigs. In phase 1, both combinations provided similar anesthetic effects, with KMXS providing moderate anesthesia for 60-70 minutes and TZX providing anesthesia for 30-45 minutes. In phase 2, castration was completed smoothly in all pigs with little fluctuation in physiological variables.
Article
Veterinary Sciences
Katharine A. A. McIver, Shannon D. D. Boveland, Stuart C. C. Clark-Price, Erik H. H. Hofmeister
Summary: This study aims to investigate the effects of tiletamine-zolazepam and propofol on intraocular pressure (IOP) in dogs. The results showed that dogs receiving tiletamine-zolazepam had significantly less elevation in IOP at induction and intubation compared to those receiving propofol.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Li-en Chang, Jeff C. Ko, Ann B. Weil, Hsin-Yi Weng
Summary: The study evaluated and compared the anesthetic effects of different drug combinations in pigs and found that tolazoline administration significantly shortened the duration of anesthetic recovery without affecting the quality of recovery.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Oksana N. Khokhlova, Natalya A. Borozdina, Elena S. Sadovnikova, Irina A. Pakhomova, Pavel A. Rudenko, Yuliya V. Korolkova, Sergey A. Kozlov, Igor A. Dyachenko
Summary: CO2 inhalation is a commonly used method for euthanasia and blood sampling in laboratory rats and mice, but it has been criticized for animal welfare issues. This study compared the stability of biochemical parameters in serum collected after CO2 inhalation or the intramuscular injection of TZX. The results showed that TZX injection reduced the levels of various biochemical parameters and was a more feasible method for terminal blood sampling, reducing animal suffering.
Article
Veterinary Sciences
Maria E. Baier, Eduardo R. Monteiro, Jose R. Herrera Becerra, Luiz G. B. Martins, Mariana J. Souza
Summary: The study aimed to determine the effective dosage of the combination tiletamine-zolazepam-ketamine-xylazine (TKX) with or without methadone in dogs. The results provide guidance on the volumes of TKX and TKXM for dogs requiring restraint for minimally invasive procedures. Inclusion of methadone in the TKX combination did not influence the effective dose.
VETERINARY ANAESTHESIA AND ANALGESIA
(2022)
Article
Veterinary Sciences
Krista Mitchell, Michele Barletta, Steeve Giguere, Jane Quandt, David Osborn, Eryn Watson, Bradley Cohen, Karl Miller
Summary: The study compared oxygenation and ventilation in white-tailed deer under two anesthesia treatments with and without oxygen supplementation. It was found that both treatments resulted in hypoxemia without oxygen supplementation, which improved significantly with oxygen supplementation. Additionally, oxygen supplementation decreased lactate concentration and heart rate in both treatments. Overall, both XK and XTZ treatments were deemed suitable for immobilizing white-tailed deer under the study conditions.
VETERINARY ANAESTHESIA AND ANALGESIA
(2021)
Article
Biochemistry & Molecular Biology
Ivana Palucci, Alessandro Salustri, Flavio De Maio, Maria del Carmen Pereyra Boza, Francesco Paglione, Michela Sali, Luca Occhigrossi, Manuela D'Eletto, Federica Rossin, Delia Goletti, Maurizio Sanguinetti, Mauro Piacentini, Giovanni Delogu
Summary: This study aimed to test the potential activity of cysteamine and cystamine against Mycobacterium abscessus. The results showed that these drugs restricted the growth of M. abscessus in human macrophages and had enhanced activity when combined with amikacin. The treatment with these drugs was more effective against MAB-S infection and reduced the inflammatory response triggered by MAB-R infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Justyna M. Przystal, Hannes Becker, Denis Canjuga, Foteini Tsiami, Nicole Anderle, Anna-Lena Keller, Anja Pohl, Carola H. Ries, Martina Schmittnaegel, Nataliya Korinetska, Marilin Koch, Jens Schittenhelm, Marcos Tatagiba, Christian Schmees, Susanne C. Beck, Ghazaleh Tabatabai
Summary: This study investigated treatment strategies that target tumor-associated macrophages in the microenvironment by blocking CSF1R, alone or in combination with PD1 blockade. The results suggest that targeting CSF1R is a promising therapeutic approach for glioblastoma, potentially in conjunction with PD1 inhibition, as shown by increased survival in mouse models and enhanced attack of the immune system in ex vivo microtumor models.
Article
Oncology
Prachi Bhave, Tasnia Ahmed, Serigne N. Lo, Alexander Shoushtari, Anne Zaremba, Judith M. Versluis, Joanna Mangana, Michael Weichenthal, Lu Si, Thierry Lesimple, Caroline Robert, Claudia Trojanello, Alexandre Wicky, Richard Heywood, Lena Tran, Kathleen Batty, Florentia Dimitriou, Anna Stansfeld, Clara Allayous, Julia K. Schwarze, Meghan J. Mooradian, Oliver Klein, Inderjit Mehmi, Rachel Roberts-Thomson, Andrea Maurichi, Hui-Ling Yeoh, Adnan Khattak, Lisa Zimmer, Christian U. Blank, Egle Ramelyte, Katharina C. Kaehler, Severine Roy, Paolo A. Ascierto, Olivier Michielin, Paul C. Lorigan, Douglas B. Johnson, Ruth Plummer, Celeste Lebbe, Bart Neyns, Ryan Sullivan, Omid Hamid, Mario Santinami, Grant A. McArthur, Andrew M. Haydon, Georgina Long, Alexander M. Menzies, Matteo S. Carlino
Summary: Acral melanoma is a rare subtype with poor prognosis, and there is a lack of prospective clinical trial evidence on the efficacy of checkpoint inhibitors in this population. The study found that initial anti-PD-1/ipilimumab combination had a significantly higher ORR compared to anti-PD-1 alone, but this benefit did not translate to improved OS in this retrospective cohort. Primary site did not impact treatment outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Pharmacology & Pharmacy
Danmei Yu, Zhou Lu, Ruyu Wang, Yusen Xiang, Hongtao Li, Jiani Lu, Lijun Zhang, Hongzhuan Chen, Weihua Li, Xin Luan, Lili Chen
Summary: Farnesoid X receptor (FXR) is considered a tumor suppressor for colorectal and liver cancers. The interaction between FXR, bile acids, and gut microbiota is closely associated with an increased risk of these cancers. Combination therapy using FXR agonists is receiving attention as a potential treatment approach for improved efficacy and reduced side effects.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Immunology
Yi Que, Juan Wang, Jia Zhu, Na Li, Junting Huang, Suying Lu, Feifei Sun, Lian Zhang, Zijun Zhen, Li Zhang, Ruiqing Cai, Haixia Guo, Xiaofei Sun, Yizhuo Zhang
Summary: Limited experience of PD-1 antibody combined with other therapies in children was explored in a retrospective case study in Chinese expert centers. The study demonstrated antitumor activity of PD-1 antibody monotherapy in pediatric patients with Hodgkin lymphoma, while no objective response was observed in patients with melanoma or Burkitt lymphoma. The combination of PD-1 antibody with decitabine showed potential efficacy in pediatric patients with advanced embryonal rhabdomyosarcoma and lymphoepitheliomatoid-like carcinoma, with no severe treatment-related adverse events attributed to PD-1 antibody monotherapy in Asian pediatric patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Martin Gutierrez, Victor Moreno, Kimberley M. Heinhuis, Anthony J. Olszanski, Anna Spreafico, Michael Ong, Quincy Chu, Richard D. Carvajal, Jose Trigo, Maria Ochoa De Olza, Mariano Provencio, Filip Yves De Vos, Filippo De Braud, Stephen Leong, Deanne Lathers, Rui Wang, Palani Ravindran, Yan Feng, Praveen Aanur, Ignacio Melero
Summary: This study evaluated the safety and activity of BMS-986178 in combination with nivolumab and/or ipilimumab in patients with advanced solid tumors. The results showed a manageable safety profile, but no clear efficacy signal was observed above that expected for nivolumab and/or ipilimumab.
CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Subhash Dwivedi, Anuhya Gottipati, Raghu Ganugula, Meenakshi Arora, Richard Friend, Robert Osburne, Aline Rodrigues-Hoffman, Rita Basu, Hui-Lin Pan, M. N. V. Ravi Kumar
Summary: The study suggests that double-headed nanosystems containing curcumin (nCUR) can alleviate diabetic peripheral neuropathy (DPN) and show better outcomes when combined with long-acting subcutaneous insulin (INS). nCUR can protect nerve axons and fibers, reduce inflammation and cell death. Therefore, nCUR may be a potential treatment for DPN.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Bingjie Fu, Xiaojing Dou, Miao Zou, Hao Lu, Kaixuan Wang, Qingxia Liu, Yao Liu, Wei Wang, Meihua Jin, Dexin Kong
Summary: Amlodipine can suppress lung cancer cell proliferation by modulating multiple signaling pathways and protein expression, and it shows a good therapeutic effect when used alone or in combination with gefitinib.
FRONTIERS IN PHARMACOLOGY
(2022)
