Article
Chemistry, Organic
Jonas Rickhoff, Niklas B. Arndt, Marcus Boeckmann, Nikos L. Doltsinis, Bart Jan Ravoo, Luuk Kortekaas
Summary: Azobenzenes are well-studied molecular photoswitches and are important in the search for red-shifted photoresponsive materials. The current approaches mostly rely on aromatic substitution patterns to achieve visible light application, sometimes combined with protonation to produce red-shifted azonium species. This study demonstrates that steady-state protonation of the azo-bridge is possible in simple azobenzenes, leading to the formation of both Z- and E-azonium species. Protonation of para-methoxyazobenzene specifically yields photoisomerizable azonium ions with reversed switching direction under visible light irradiation.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Wuyu Mao, Jie Tang, Liqun Dai, Xinyu He, Jie Li, Larry Cai, Ping Liao, Ruotian Jiang, Jingwei Zhou, Haoxing Wu
Summary: A novel strategy has been developed to create highly fluorescent Huaxi-Fluor probes that exhibit significantly increased fluorescence upon forming the bioorthogonal reaction product, pyridazine. These probes have large Stokes shifts and high quantum yields, with emission wavelengths fine-tunable from 556 to 728 nm by manipulating the fluorophore skeleton. Highly photo-stable and biocompatible, these probes are suitable for live cell organelle visualization without washing steps and imaging tumors in live small animals to depths of 500 μm by two-photon excitation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Hiromasa Takahashi, Hiroyuki Watanabe, Shunichiro Ito, Kazuo Tanaka, Yoshiki Chujo
Summary: We synthesized new binuclear boron complexes based on pyrazine with ortho and para substitution patterns. The para-linked complexes showed a narrow energy gap between highest occupied and lowest unoccupied molecular orbitals, resulting in far-red to near-infrared emission properties. Meanwhile, the ortho-substituted complex exhibited orange emission. The theoretical study suggested that the para-substitution did not significantly perturb the characteristic HOMO distribution originating from pyrazine, unlike the ortho-substituted one.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Zhiwei Zhang, Wenhui Wang, Michael O'Hagan, Jinghong Dai, Junji Zhang, He Tian
Summary: This review highlights recent progress in the development of red-shifted photoswitches that can be activated by visible and near-infrared light and exhibit different photochromic reaction mechanisms. These red-shifted photoswitches have great potential in biotechnology and materials chemistry applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Miroslav Medved, Mariangela Di Donato, Wybren Jan Buma, Adele D. Laurent, Lucien Lameijer, Tomas Hrivnak, Ivan Romanov, Susannah Tran, Ben L. Feringa, Wiktor Szymanski, G. Andrew Woolley
Summary: Azonium ions formed by the protonation of aminoazobenzenes can undergo photoisomerization with red light under physiological conditions. By combining transient absorption measurements and quantum chemical calculations, the researchers revealed the mechanistic details of the photon-induced isomerization process. This understanding can guide the design of improved azonium ion derivatives for better photocontrol applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Miroslav Medved, Mariangela Di Donato, Wybren Jan Buma, Adele D. Laurent, Lucien Lameijer, Tomas Hrivnak, Ivan Romanov, Susannah Tran, Ben L. Feringa, Wiktor Szymanski, G. Andrew Woolley
Summary: Azonium ions derived from aminoazobenzenes with ortho-methoxy substitutions isomerize under red light, which makes them useful for the photocontrol of physiological processes. This study provides a mechanistic understanding of the isomerization process and thermal relaxation, and suggests improvements for the design of derivatives. The study also reveals the impact of solution pH on the photoswitching behavior of azonium ions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Applied
Wei Zeng, Ling-Yun Zhu, Yong Chen, Mei-Jin Lin
Summary: A novel water-soluble conjugated macrocyclic tetramaleimide with FR/NIR fluorescence emission was designed and synthesized. The molecule possesses AIE and TICT characteristics, and fluorescence recovery in aqueous solution was achieved by introducing SLS. Bioimaging experiments on HeLa and HepG2 cells showed good performance.
Review
Biochemistry & Molecular Biology
Shang Jia, Ellen M. Sletten
Summary: The complex network of naturally occurring biological pathways has motivated the development of new synthetic molecules for interfering with and detecting these processes. Photochemical tools have emerged as a high-resolution approach to controlling the activity of drug or probe molecules. Recent advancements in far-red and near-infrared photocages and photoswitches have enabled deeper tissue penetration for studying biology in tissue and model animal settings.
ACS CHEMICAL BIOLOGY
(2021)
Article
Physics, Applied
Vageeswar Rajaram, Sungho Kang, Sila Deniz Calisgan, Antea Risso, Zhenyun Qian, Matteo Rinaldi
Summary: This paper presents a novel method for measuring infrared radiation using a micromechanical photoswitch, which enables zero-standby power IR detection and frequency-tunable AC waveform generation.
JOURNAL OF APPLIED PHYSICS
(2022)
Review
Chemistry, Applied
Zeba Khan, Nagaiyan Sekar
Summary: Xanthene dyes are widely used due to their unique photophysical properties, photostability, and ability to switch fluorescence based on the external environment. However, their emission range and stokes shifts impose limitations on their use in biological applications. This review focuses on the element substitution strategy and extending -conjugation in O-xanthene with carbon at the periphery to shift the emission of xanthene dyes towards the far-red to NIR range. The review also discusses the impact of substituents on photophysical properties and presents applications of far-red to NIR emitting xanthene dyes.
Article
Chemistry, Multidisciplinary
Xinyu Shen, Zhenyu Wang, Chengyuan Tang, Xiangtong Zhang, Bo Ram Lee, Xin Li, Daguang Li, Yu Zhang, Junhua Hu, Dan Zhao, Fujun Zhang, William W. Yu, Bin Dong, Xue Bai
Summary: This study demonstrates the achievement of electroactivated near-infrared light-emitting diodes (LEDs) based on Yb3+-doped CsPb(Cl1-xBrx)3 perovskite nanocrystals (PNCs), with emission peaks over 800 nm. These NIR LEDs exhibit extraordinary high near-infrared photoluminescence quantum yields over 170%. The main mechanism of electroluminescence (EL)-activated Yb3+ is revealed to be the ultrafast quantum cutting process from the PNC host.
Article
Chemistry, Multidisciplinary
Wuyu Mao, Weijie Chi, Xinyu He, Chao Wang, Xueyi Wang, Haojie Yang, Xiaogang Liu, Haoxing Wu
Summary: In this study, a generalizable molecular design strategy was reported to construct ultra-fluorogenic dyes by simple substitution at the meso-positions of various far-red and NIR fluorophores. The probes showed significant fluorescence turn-on ratios in the range of 586-806 nm. These results will greatly expand the applications of bioorthogonal chemistry in NIR bioimaging and biosensing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Shang Jia, Ellen M. Sletten
Summary: This Review highlights recent developments in synthetic far-red and near-infrared photocages and photoswitches and their current and potential applications at the interface of chemistry and biology.
ACS CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Organic
Supriya Bhunia, Anirban Dolai, Satyajit Bera, Subhas Samanta
Summary: This study discovered that arylazopyrazoles with para-dimethylamine and para-pyrrolidine substitutions display very high or near-quantitative bidirectional isomerization under different light sources, and exhibit reasonable thermal stability and impressive stability to reduction.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Natsuho Moriyama, Jiro Abe
Summary: Selective bidirectional photoconversion reactions between stable and metastable isomers of 3-phenylperylenyl-bridged imidazole dimer can be achieved with high conversion ratios by irradiation with different visible light wavelengths. The absorption bands of the two isomers are largely separated by more than 140 nm, allowing for selective reactions with 660 nm and 460 nm light. Also, complete forward reactions can be achieved with near-infrared light of 785 nm.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Immunology
Xiaolin Wang, Jin Sun, Luming Wan, Xiaopan Yang, Haotian Lin, Yanhong Zhang, Xiang He, Hui Zhong, Kai Guan, Min Min, Zhenxue Sun, Xiaoli Yang, Bin Wang, Mingxin Dong, Congwen Wei
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Chemistry, Medicinal
Zhuguo Liu, Zheng Yu, Shuo Yu, Cui Zhu, Mingxin Dong, Wenxiang Mao, Jie Hu, Mary Prorok, Ruibin Su, Qiuyun Dai
Summary: The study reported a selective NMDAR GluN2B antagonist con-T[M8Q] that potently inhibits morphine dependence in mice with low side effects. The compound effectively inhibits the transcription and expression levels of signaling molecules related to NMDAR NR2B subunit in the hippocampus.
Article
Chemistry, Applied
Fushuai Li, Zhihong Yang, Yanyan Yang, Qiuhong Huang, Xuling Chen, Pengfei Li, Mingxin Dong, Wenjun Li
Summary: A chiral phosphorus acid catalyzed enantioselective 1,4-conjugate addition of arylamines to in situ formed 7-methylene-7H-indoles from 7-indolylmethanols has been successfully developed for the first time without the use of additives. The catalytic protocol enables the formation of 1,4-adducts with a nitrogen-containing tertiary carbon stereocenter in moderate to high yields and good enantioselectivity under mild reaction conditions.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Applied
Xiao Lin, Keli Ge, Ningning He, Xuling Chen, Pengfei Li, Mingxin Dong, Wenjun Li
Summary: A chiral phosphoric acid-catalyzed enantioselective aza-addition reaction of arylamines with ketimines has been developed, resulting in the construction of chiral acyclic N,N-acetal motifs. The reaction proceeds smoothly under standard conditions, yielding a series of acyclic N,N-acetals in 82-99% yield with 80-96% ee.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Medical Laboratory Technology
Lusia Sepiashvili, Zaman Alli, Mary Kathryn Bohn, Alexandra Hall, Amir Karin, Kazunori Murata, Khosrow Adeli
Summary: Cytokine measurements in pediatric populations are common, but accurate reference intervals are lacking. This study established age- and sex-specific pediatric reference values for key inflammatory markers, highlighting the complexity and variability of cytokine profiles in children. Interpretation of test results should take into account age and sex-specific reference intervals for more accurate clinical decision making.
CLINICAL BIOCHEMISTRY
(2021)
Article
Microbiology
Jin Sun, Xiaolin Wang, Haotian Lin, Luming Wan, Ji Chen, Xiaopan Yang, Dongyu Li, Yanhong Zhang, Xiang He, Bin Wang, Mingxin Dong, Hui Zhong, Congwen Wei
Summary: The study revealed that the effector protein IpaH4.5 disrupts MPR trafficking and lysosomal function, counteracting host lysosomal degradation. IpaH4.5 harbors TBC-like dual-finger motifs and exhibits potent RabGAP activities towards Rab31. By targeting Rab31, IpaH4.5 disrupts the transport of CD-MPR, attenuating lysosomal function in S. flexneri infection.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jaewan Jang, G. Andrew Woolley
Summary: Photoswitchable proteins play a crucial role in optogenetics, allowing specific molecular events in complex biological settings to be probed. Recent advancements in this field, facilitated by directed evolution approaches in vitro, bacteria, or yeast, have paved the way for future developments.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Ryan M. Woloschuk, P. Maximilian M. Reed, Anna S. Jaikaran, Karl Z. Demmans, Jeffrey Youn, Voula Kanelis, Maruti Uppalapati, G. Andrew Woolley
Summary: The research focused on developing a photo-controlled affinity reagent Z-PYP to achieve controllable switching of target affinity in the dark and under light. Experimental results confirmed that mutants with decreased Z-domain folding energy could alter target affinity without affecting switching.
Article
Biochemistry & Molecular Biology
Jaewan Jang, P. Maximilian M. Reed, Sarah Rauscher, G. Andrew Woolley
Summary: This study identifies the molecular factors and predictable effects of point mutations on the thermal reversion rates of canonical red/green CBCR GAF domains. The presence of a glycine residue is found to affect the conformational dynamics of chromophore-interacting residues and enhance the thermal reversion rate from green-absorbing to red-absorbing state.
Article
Chemistry, Organic
Yan Xia, Meiwen Liu, Chenxiao Qian, Pengfei Li, Mingxin Dong, Wenjun Li
Summary: This study achieved the enantioselective construction of chiral spiro N,N-acetal carbon stereocenters and axially chiral 3-arylindoles through a chiral phosphoric acid catalyzed annulation reaction. The reaction between alpha-(3-isoindolinonyl) propargylic alcohols and 1-(3-indolyl)naphthalen-2-ols resulted in a wide range of pyrrolo[1,2-a]indoles with enantioenriched spiro isoindolinone-indoline and atropisomeric naphthalenol frameworks. A possible mechanism was proposed based on control experiments and previous work.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemical Research Methods
Jaewan Jang, Kun Tang, Jeffrey Youn, Sherin McDonald, Hannes M. Beyer, Matias D. Zurbriggen, Maruti Uppalapati, G. Andrew Woolley
Summary: By engineering synthetic light-dependent interactors, we developed bidirectional, cyanobacteriochrome-based light-inducible dimers (BICYCL) for optogenetic control of protein-protein interactions with green and red light. This systematic approach enables the future engineering of a broad chromatic palette of CBCRs for optogenetics use.
Article
Biochemical Research Methods
Ji Chen, Jinyu Wang, Hongyu Zhu, Yang Zhang, Jin Sun, Wei Wang, Congwen Wei, Hui Zhong, Mingxin Dong
Summary: Researchers report a novel method to construct recombinant influenza A virus regulated by small molecules. By inserting 4-hydroxytamoxifen (4-HT)-dependent intein into the polymerase acidic (PA) protein of IAV, a series of 4-HT-dependent recombinant viruses were generated and screened. The attenuated viruses showed excellent replication characteristics and elicited robust immunity against homologous viruses.
ACS SYNTHETIC BIOLOGY
(2023)
Article
Chemistry, Organic
Nobuo Yasuike, Chihiro Kachi-Terajima, Amir Karin, Takashi Mino, G. Andrew Woolley
Summary: Thiol-reactive reagents cannot be used for the modification of intracellular targets due to the presence of high concentrations of glutathione. This study proposes an equilibrium, entropic strategy using a cyanoacrylate-based thiol-reactive cross-linker to achieve target selectivity. The cross-linker shows high selectivity for reaction with target peptides and proteins containing paired thiols.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Medical Laboratory Technology
Amir Karin, Vathany Kulasingam, Lucas B. Chartier, Angela Ejumudo, Talya Wolff, Davor Brinc
Summary: This research compared the critical result notification policies of several North American laboratories, finding that most labs have restrictions on notifying recurrent critical results. In one institution, it was discovered that removing these restrictions would significantly increase the daily volume of calls, and the choice of critical thresholds also impacts the number of notification calls.
JOURNAL OF APPLIED LABORATORY MEDICINE
(2021)
Article
Medical Laboratory Technology
Amir Karin, Davor Brinc, Felix Leung, Benjamin P. Jung
Summary: In patients with severe hypernatremia, there is a clinically significant positive proportional bias in sodium results generated by a blood gas analyzer compared to the plasma results from a chemistry analyzer. Differences in sodium results provided by different methods can be misleading and dangerous, especially in patients with severe hypernatremia.
JOURNAL OF APPLIED LABORATORY MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
