Journal
MICROBES AND INFECTION
Volume 18, Issue 5, Pages 302-309Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2016.02.001
Keywords
Salmonella; Pathogenicity island; Excision; Virulence
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Funding
- Fondo Nacional de Ciencia y Tecnologia de Chile (FONDECYT) [11075060, 1131012, 1140010, 1150862]
- Millennium Institute on Immunology and Immunotherapy from Iniciativa Cientifica Milenio, Ministry of Economy of Chile
- Grant Nouvelles Equipes-nouvelles thematiques from la Region Pays de la Loire
- Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
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Pathogenicity islands (PAIs) are regions of the chromosome of pathogenic bacteria that harbor virulence genes, which were probably acquired by lateral gene transfer. Several PAIs can excise from the bacterial chromosome by site-specific recombination and in this review have been denominated excisable PAIs . Here, the characteristic of some of the excisable PAIs from Salmonella enterica and the possible role and impact of the excision process on bacterial virulence is discussed. Understanding the role of PAI excision could provide important insights relative to the emergence, evolution and virulence of pathogenic enterobacteria. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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