Journal
MICROBES AND INFECTION
Volume 18, Issue 9, Pages 529-535Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2016.04.001
Keywords
Osteoclastogenesis; Brucella abortus; B cells
Categories
Funding
- Agencia Nacional of Promocion Cientifica y Tecnologica (ANPCYT, Argentina) [PICT 2010-0023, PICT 2011-1501, PICT 2011-1200, PICT 2012-2252]
- Universidad de Buenos Aires [UBACYT 20020090200012, 20020120100128]
- CONICET
- ANPCyT
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Brucella abortus is an intracellular bacterium that establishes lifelong infections in livestock and humans although the mechanisms of its chronicity are poorly understood. Activated B cells have long lifespan and B. abortus infection activates B cells. Our results indicate that the direct infection of B cells with B. abortus induced matrix metalloproteinase-9 (MMP-9), receptor activator for NF kappa B ligand (RANKL), tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 secretion. In addition, supernatants from B. abortus-infected B cells induced bone marrow derived monocytes to undergo osteoclastogenesis. Using osteoprotegerin, RANKL's decoy receptor, we determined that RANKL is involved in osteoclastogenesis induced by supernatants from B. abortus-infected B cells. The results presented here shed light on how the interactions of B. abortus with B cells may have a role in the pathogenesis of brucellar osteoarticular disease. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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