Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

Potent and selective HDAC6 inhibitory activity of N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A

(2013) Rob De Vreese et al.   CHEMICAL COMMUNICATIONS

Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects

(2013) Santosh Vishwakarma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Potent Histone Deacetylase Inhibitors Derived from 4-(Aminomethyl)-N-hydroxybenzamide with High Selectivity for the HDAC6 Isoform

(2013) Christopher Blackburn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif

(2013) Florence F. Wagner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quinazolin-4-one Derivatives as Selective Histone Deacetylase-6 Inhibitors for the Treatment of Alzheimer’s Disease

(2013) Chao-Wu Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a histone deacetylase 6 inhibitor and its biological effects

(2013) J.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Cinnamyl Hydroxyamides and 2-Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity

(2011) Sergio Valente et al.   ChemMedChem

Bromination of 3-substituted benzo[b]thiophenes: access to Raloxifen intermediate

(2011) François Liger et al.   TETRAHEDRON LETTERS

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

(2010) Kyle V. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Focal Nature of Neurological Disorders Necessitates Isotype-Selective Histone Deacetylase (HDAC) Inhibitors

(2009) Elizabeth A. Thomas   MOLECULAR NEUROBIOLOGY

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

(2008) David V. Smil et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY