Graves’ Orbitopathy Models: Valuable Tools for Exploring Pathogenesis and Treatment

Rapamycin improves Graves’ orbitopathy by suppressing CD4+ cytotoxic T lymphocytes

(2022) Meng Zhang et al.   JCI Insight

A novel CD4+ CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves’ orbitopathy

(2021) Yue Wang et al.   Cellular & Molecular Immunology

Predicting the Relapse of Hyperthyroidism in Treated Graves’ Disease with Orbitopathy by Serial Measurements of TSH-Receptor Autoantibodies

(2021) Mareile Stöhr et al.   HORMONE AND METABOLIC RESEARCH

Modulating gut microbiota in a mouse model of Graves’ orbitopathy and its impact on induced disease

(2021) Sajad Moshkelgosha et al.   Microbiome

Teprotumumab: interpreting the clinical trials in the context of thyroid eye disease pathogenesis and current therapies.

(2021) Bryan J. Winn et al.   OPHTHALMOLOGY

Mechanisms That Underly T Cell Immunity in Graves’ Orbitopathy

(2021) Sijie Fang et al.   Frontiers in Endocrinology

Predicting the Course of Graves’ Orbitopathy Using Serially Measured TSH-Receptor Autoantibodies by Automated Binding Immunoassays and the Functional Bioassay

(2021) Svenja Philipp et al.   HORMONE AND METABOLIC RESEARCH

A cyclic peptide significantly improves thyroid function, thyrotropin-receptor antibodies and orbital mucine /collagen content in a long-term Graves’ disease mouse model

(2021) Tanja Diana et al.   JOURNAL OF AUTOIMMUNITY

An Early Wave of Macrophage Infiltration Intertwined with Antigen-Specific Proinflammatory T Cells and Browning of Adipose Tissue Characterizes the Onset of Orbital Inflammation in a Mouse Model of Graves' Orbitopathy

(2021) Svenja Philipp et al.   THYROID

Teprotumumab for the Treatment of Active Thyroid Eye Disease

(2020) Raymond S. Douglas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparative assessment of gut microbial composition and function in patients with Graves’ disease and Graves’ orbitopathy

(2020) T.-T. Shi et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

A Promising Mouse Model of Graves’ Orbitopathy Induced by Adenovirus Expressing Thyrotropin Receptor A Subunit

(2020) Meng Zhang et al.   THYROID

Current and Emerging Treatment Strategies for Graves’ Orbitopathy

(2019) Natalia Genere et al.   DRUGS

Therapeutic effects of short cyclic and combined epitope peptides in a long-term model of Graves´ disease and orbitopathy

(2019) Julia Fassbender et al.   THYROID

Alterations in the intestinal microbiota of patients with severe and active Graves’ orbitopathy: a cross-sectional study

(2019) T.-T. Shi et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Fingolimod improves the outcome of experimental Graves’ disease and associated orbitopathy by modulating the autoimmune response to the thyroid stimulating hormone receptor

(2019) Svenja Plöhn et al.   THYROID

New insights into the pathogenesis and nonsurgical management of Graves orbitopathy

(2019) Peter N. Taylor et al.   Nature Reviews Endocrinology

Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 × 2 factorial, double-blind, randomised controlled trial

(2018) Rathie Rajendram et al.   Lancet Diabetes & Endocrinology

Gut microbiota in experimental murine model of Graves’ orbitopathy established in different environments may modulate clinical presentation of disease

(2018) Giulia Masetti et al.   Microbiome

Efficacy of Tocilizumab in Patients With Moderate-to-Severe Corticosteroid-Resistant Graves Orbitopathy: A Randomized Clinical Trial

(2018) Jose V. Perez-Moreiras et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Gut Microbiome in BALB/c and C57BL/6J Mice Undergoing Experimental Thyroid Autoimmunity Associate with Differences in Immunological Responses and Thyroid Function

(2018) Sajad Moshkelgosha et al.   HORMONE AND METABOLIC RESEARCH

Molecular Alteration Analysis of Human Gut Microbial Composition in Graves' disease Patients

(2018) Hafiz Muhammad Ishaq et al.   International Journal of Biological Sciences

Graves’ orbitopathy occurs sex-independently in an autoimmune hyperthyroid mouse model

(2018) Anke Schlüter et al.   Scientific Reports

The involvement of T cell pathogenesis in thyroid-associated ophthalmopathy

(2018) Yazhuo Huang et al.   EYE

Cyclic Peptides for Effective Treatment in a Long-Term Model of Graves Disease and Orbitopathy in Female Mice

(2017) Hans-Peter Holthoff et al.   ENDOCRINOLOGY

Regulation of Orbital Fibrosis and Adipogenesis by Pathogenic Th17 Cells in Graves Orbitopathy

(2017) Sijie Fang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Teprotumumab for Thyroid-Associated Ophthalmopathy

(2017) Terry J. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Advances in treatment of active, moderate-to-severe Graves' ophthalmopathy

(2017) Wilmar M Wiersinga   Lancet Diabetes & Endocrinology

Comparative Assessment of Female Mouse Model of Graves' Orbitopathy Under Different Environments, Accompanied by Proinflammatory Cytokine and T-Cell Responses to Thyrotropin Hormone Receptor Antigen

(2016) Utta Berchner-Pfannschmidt et al.   ENDOCRINOLOGY

Current perspectives on the role of orbital fibroblasts in the pathogenesis of Graves' ophthalmopathy

(2016) Willem A. Dik et al.   EXPERIMENTAL EYE RESEARCH

IL-17A Exacerbates Fibrosis by Promoting the Proinflammatory and Profibrotic Function of Orbital Fibroblasts in TAO

(2016) Sijie Fang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Thyroid hormones and cardiovascular disease

(2016) Avais Jabbar et al.   Nature Reviews Cardiology

Pathogenesis of thyroid eye disease: review and update on molecular mechanisms

(2015) Jwu Jin Khong et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Prolonged TSH Receptor A Subunit Immunization of Female Mice Leads to a Long-Term Model of Graves' Disease, Tachycardia, and Cardiac Hypertrophy

(2015) Hans-Peter Holthoff et al.   ENDOCRINOLOGY

Randomized Controlled Trial of Rituximab in Patients With Graves' Orbitopathy

(2015) Marius N. Stan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Efficacy of B-Cell Targeted Therapy With Rituximab in Patients With Active Moderate to Severe Graves' Orbitopathy: A Randomized Controlled Study

(2015) Mario Salvi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Crystal Structure of a TSH Receptor Monoclonal Antibody: Insight Into Graves' Disease Pathogenesis

(2015) Chun-Rong Chen et al.   MOLECULAR ENDOCRINOLOGY

TSH-receptor-expressing fibrocytes and thyroid-associated ophthalmopathy

(2015) Terry J. Smith   Nature Reviews Endocrinology

B Cells from Patients with Graves' Disease Aberrantly Express the IGF-1 Receptor: Implications for Disease Pathogenesis

(2014) R. S. Douglas et al.   JOURNAL OF IMMUNOLOGY

Extrathyroidal manifestations of Graves’ disease: a 2014 update

(2014) Luigi Bartalena et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Cutting Edge: Retrobulbar Inflammation, Adipogenesis, and Acute Orbital Congestion in a Preclinical Female Mouse Model of Graves' Orbitopathy Induced by Thyrotropin Receptor Plasmid-in Vivo Electroporation

(2013) Sajad Moshkelgosha et al.   ENDOCRINOLOGY

Examination of Orbital Tissues in Murine Models of Graves' Disease Reveals Expression of UCP-1 and the TSHR in Retrobulbar Adipose Tissues

(2013) K.T. Johnson et al.   HORMONE AND METABOLIC RESEARCH

Role of Self-Tolerance and Chronic Stimulation in the Long-Term Persistence of Adenovirus-Induced Thyrotropin Receptor Antibodies in Wild-Type and Transgenic Mice

(2012) Sandra M. McLachlan et al.   THYROID

Orbital fibrosis in a mouse model of Graves' disease induced by genetic immunization of thyrotropin receptor cDNA

(2011) Shuang-Xia Zhao et al.   JOURNAL OF ENDOCRINOLOGY

Thyroid-associated ophthalmopathy; quality of life follow-up of patients randomized to treatment with antithyroid drugs or radioiodine

(2010) Mirna Abraham-Nordling et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Graves' Ophthalmopathy

(2010) Rebecca S. Bahn   NEW ENGLAND JOURNAL OF MEDICINE

Euthyroid and primarily hypothyroid patients develop milder and significantly more asymmetrical Graves ophthalmopathy

(2009) A K Eckstein et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Toward Better Models of Hyperthyroid Graves' Disease

(2009) Selc¸uk Dağdelen et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA