HK-2 cell response to TGF-β highly depends on cell culture medium formulations

Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression

(2022) Gábor Kökény et al.   KIDNEY INTERNATIONAL

Comprehensive metabolomic study of the response of HK-2 cells to hyperglycemic hypoxic diabetic-like milieu

(2021) Alberto Valdés et al.   Scientific Reports

How Many Cell Types Are in the Kidney and What Do They Do?

(2021) Michael S. Balzer et al.   Annual Review of Physiology

Pathophysiology of AKI to CKD progression

(2020) Yuki Sato et al.   SEMINARS IN NEPHROLOGY

Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis

(2020) Milica Bozic et al.   Nature Communications

Fetal bovine serum enlarges the size of human pancreatic cancer spheres accompanied by an increase in the expression of cancer stem cell markers

(2019) Norihiko Sasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The PPARγ agonist pioglitazone prevents TGF-β induced renal fibrosis by repressing EGR-1 and STAT3

(2019) Ágnes Németh et al.   BMC Nephrology

Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies

(2019) Hyun Mi Kang et al.   Scientific Reports

PPARγ is a gatekeeper for extracellular matrix and vascular cell homeostasis

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Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing

(2017) Elisabeth H. Vollmann et al.   Molecular Therapy-Nucleic Acids

Egr-1 Mediates Chronic Hypoxia-Induced Renal Interstitial Fibrosis via the PKC/ERK Pathway

(2017) Shiren Sun et al.   AMERICAN JOURNAL OF NEPHROLOGY

In vitro systems to study nephropharmacology: 2D versus 3D models

(2016) Natalia Sánchez-Romero et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Egr-1 deficiency protects from renal inflammation and fibrosis

(2016) Li-Chun Ho et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Renal tubular epithelium-targeted peroxisome proliferator-activated receptor-γ maintains the epithelial phenotype and antagonizes renal fibrogenesis

(2016) Min Zhao et al.   Oncotarget

Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes

(2015) J. W. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Next-generation sequencing identifies TGF-β1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy

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Egr-1: new conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis)

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The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule

(2012) Sarah E. Jenkinson et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Glutamatergic Signaling Maintains the Epithelial Phenotype of Proximal Tubular Cells

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Early growth response transcription factors: Key mediators of fibrosis and novel targets for anti-fibrotic therapy

(2011) Swati Bhattacharyya et al.   MATRIX BIOLOGY

Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters

(2009) Martijn J. Wilmer et al.   CELL AND TISSUE RESEARCH