Synthesis, molecular docking, ADMET, and evaluation of the anxiolytic effect in adult zebrafish of synthetic chalcone (E)‐3‐(4‐(dimethylamino)phenyl)‐1‐(2‐hydroxyphenyl)prop‐2‐en‐1‐one: An in vivo and in silico approach

ADMET study, spectroscopic characterization and effect of synthetic nitro chalcone in combination with norfloxacin, ciprofloxacin, and ethidium bromide against Staphylococcus aureus efflux pumps

(2022) Janaína E. Rocha et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence

(2021) Gustavo R. Villas-Boas et al.   Pharmaceuticals

Chalcones reverse the anxiety and convulsive behavior of adult zebrafish

(2021) Maria Kueirislene Amâncio Ferreira et al.   EPILEPSY & BEHAVIOR

Diterpene Sonderianin isolated from Croton blanchetianus exhibits acetylcholinesterase inhibitory action and anxiolytic effect in adult zebrafish (Danio rerio) by 5-HT system

(2021) Joyce dos Reis Lima et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Design, synthesis, biological evaluation and molecular docking studies of new chalcone derivatives containing diaryl ether moiety as potential anticancer agents and tubulin polymerization inhibitors

(2020) Guangcheng Wang et al.   BIOORGANIC CHEMISTRY

Virtual screening based on molecular docking of possible inhibitors of Covid-19 main protease

(2020) Emanuelle Machado Marinho et al.   MICROBIAL PATHOGENESIS

Structural characterization, electronic properties, and anxiolytic-like effect in adult zebrafish (Danio rerio) of cinnamaldehyde chalcone

(2020) Jayze da Cunha Xavier et al.   JOURNAL OF MOLECULAR STRUCTURE

COVID-19 and mental health in Brazil: Psychiatric symptoms in the general population

(2020) Jeferson Ferraz Goularte et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Zebrafish as a preclinical in vivo screening model for nanomedicines

(2019) Sandro Sieber et al.   ADVANCED DRUG DELIVERY REVIEWS

Molecular Docking: Shifting Paradigms in Drug Discovery

(2019) Luca Pinzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Use of Zebrafish in Drug Discovery Toxicology

(2019) Steven Cassar et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Chalcone Derivatives: Promising Starting Points for Drug Design

(2017) Marcelo Gomes et al.   MOLECULES

Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays

(2017) Débora Cristina da Silva Lima et al.   PLoS One

Adult Zebrafish (Danio rerio): An Alternative Behavioral Model of Formalin-Induced Nociception

(2017) Francisco Ernani Alves Magalhães et al.   Zebrafish

Synthesis, spectral linearity, antimicrobial, antioxidant and insect antifeedant activities of some 2,5-dimethyl-3-thienyl chalcones

(2017) Ganesan Vanangamudi et al.   Arabian Journal of Chemistry

Synthesis and anticonvulsant activity of some 2-pyrazolines derived from chalcones

(2017) Nagihan Beyhan et al.   Arabian Journal of Chemistry

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery

(2016) Travis T. Wager et al.   ACS Chemical Neuroscience

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

(2016) Antoine Daina et al.   ChemMedChem

Synthesis, Biological Evaluation and Molecular Modelling of 2′-Hydroxychalcones as Acetylcholinesterase Inhibitors

(2016) Sri Sukumaran et al.   MOLECULES

Advancements in zebrafish applications for 21st century toxicology

(2016) Gloria R. Garcia et al.   PHARMACOLOGY & THERAPEUTICS

The role of serotonin 5-HT2A receptors in memory and cognition

(2015) Gongliang Zhang et al.   Frontiers in Pharmacology

Risperidone and the 5-HT2AReceptor Antagonist M100907 Improve Probabilistic Reversal Learning in BTBR T + tf/J Mice

(2014) Dionisio A. Amodeo et al.   Autism Research

Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals

(2014) Slobodan Rendic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Molecular Targeted Approaches to Cancer Therapy and Prevention Using Chalcones

(2014) Danielle Jandial et al.   CURRENT CANCER DRUG TARGETS

Serotonin antagonists induce anxiolytic and anxiogenic-like behavior in zebrafish in a receptor-subtype dependent manner

(2014) Magda Nowicki et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

(2014) Kathleen S. Tatem et al.   Jove-Journal of Visualized Experiments

Pharmacokinetics

(2013) Jianghong Fan et al.   BIOCHEMICAL PHARMACOLOGY

α-Glucosidase inhibition by luteolin: Kinetics, interaction and molecular docking

(2013) Jiakai Yan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Drug discovery in pharmaceutical industry: productivity challenges and trends

(2012) Ish Khanna   DRUG DISCOVERY TODAY

Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

(2011) Arup K. Ghose et al.   ACS Chemical Neuroscience

Effects of anxiolytics in zebrafish: Similarities and differences between benzodiazepines, buspirone and ethanol

(2011) Daiane L. Gebauer et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Pharmacological analysis of zebrafish (Danio rerio) scototaxis

(2011) Caio Maximino et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The graphical representation of ADME-related molecule properties for medicinal chemists

(2010) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice

(2010) A.S. Mohamad et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

An Alternative Method for the Evaluation of Docking Performance: RSR vs RMSD

(2008) Dilmurat Yusuf et al.   Journal of Chemical Information and Modeling