Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 28, Pages 6161-6163Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc00356c
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Acid ceramidase is responsible for the ultimate step in the catabolism of (glyco)sphingolipids by hydrolysis of ceramide into sphingosine and free fatty acid. Deficiency in acid ceramidase is the molecular basis of Farber disease. Here we report the synthesis and characterization of an activity-based acid ceramidase probe.
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