Harnessing the combined effect of antivirulence agent trans-chalcone with bactericidal curcumin against sortase A enzyme to tackle Gram-positive bacterial infections

Isoflavone glucoside genistin, an inhibitor targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria monocytogenes in vivo and in vitro

(2023) Minda Liu et al.   BIOCHEMICAL PHARMACOLOGY

Wogonin attenuates the pathogenicity of Streptococcus pneumoniae by double‐target inhibition of Pneumolysin and Sortase A

(2023) Kuan Gu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sortase A Inhibitor Protein Nanoparticle Formulations Demonstrate Antibacterial Synergy When Combined with Antimicrobial Peptides

(2023) Sitah Alharthi et al.   MOLECULES

Punicalagin, an Inhibitor of Sortase A, Is a Promising Therapeutic Drug to Combat Methicillin-Resistant Staphylococcus aureus Infections

(2022) Wu Song et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The protection effect of rhodionin against methicillin-resistant Staphylococcus aureus-induced pneumonia through sortase A inhibition

(2022) Xingye Wang et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Targeting Bacterial Sortases in Search of Anti-virulence Therapies with Low Risk of Resistance Development

(2021) Georgiana Nitulescu et al.   Pharmaceuticals

Tideglusib and Its Analogues As Inhibitors of Staphylococcus aureus SrtA

(2020) Teng Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rutin reduces the pathogenicity of Streptococcus agalactiae to tilapia by inhibiting the activity of sortase A

(2020) Jing Dong et al.   AQUACULTURE

Astilbin Inhibits the Activity of Sortase A from Streptococcus mutans

(2019) Junxian Wang et al.   MOLECULES

PSICA: a fast and accurate web service for protein model quality analysis

(2019) Wenbo Wang et al.   NUCLEIC ACIDS RESEARCH

Discovery of natural naphthoquinones as sortase A inhibitors and potential anti‐infective solutions against Staphylococcus aureus

(2019) Georgiana Nitulescu et al.   DRUG DEVELOPMENT RESEARCH

Effect of growth media on the MTT colorimetric assay in bacteria

(2019) Ludmil Benov   PLoS One

Discovery and development of substituted thiadiazoles as inhibitors of Staphylococcus aureus Sortase A

(2019) Patrick M. Wehrli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Oligopeptide Targeting Sortase A as Potential Anti-infective Therapy for Staphylococcus aureus

(2018) Jianfeng Wang et al.   Frontiers in Microbiology

Chalcone Attenuates Staphylococcus aureus Virulence by Targeting Sortase A and Alpha-Hemolysin

(2017) Bing Zhang et al.   Frontiers in Microbiology

A versatile assay to determine bacterial and host factors contributing to opsonophagocytotic killing in hirudin-anticoagulated whole blood

(2017) Erika van der Maten et al.   Scientific Reports

Chinese herb medicine against Sortase A catalyzed transformations, a key role in gram-positive bacterial infection progress

(2016) Lifang Si et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of a New Class of Sortase A Transpeptidase Inhibitors to Tackle Gram-Positive Pathogens: 2-(2-Phenylhydrazinylidene)alkanoic Acids and Related Derivatives

(2016) Benedetta Maggio et al.   MOLECULES

Host–Bacterial Crosstalk Determines Staphylococcus aureus Nasal Colonization

(2016) Michelle E. Mulcahy et al.   TRENDS IN MICROBIOLOGY

Staphylococcal manipulation of host immune responses

(2015) Vilasack Thammavongsa et al.   NATURE REVIEWS MICROBIOLOGY

The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition

(2015) Lin Wang et al.   Frontiers in Microbiology

Discovery and structure–activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase

(2014) Dmitrijs Zhulenkovs et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sortase A: An ideal target for anti-virulence drug development

(2014) Stella Cascioferro et al.   MICROBIAL PATHOGENESIS

Antiinfective therapy with a small molecule inhibitor ofStaphylococcus aureussortase

(2014) Jie Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcumin reduces Streptococcus mutans biofilm formation by inhibiting sortase A activity

(2013) Ping Hu et al.   ARCHIVES OF ORAL BIOLOGY

Sortase A inhibitory metabolites from the roots of Pulsatilla koreana

(2013) Sooryun Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of sortase A in the pathogenesis ofStaphylococcus aureus-induced mastitis in mice

(2013) Fuguang Chen et al.   FEMS MICROBIOLOGY LETTERS

Role of Protein A in the Evasion of Host Adaptive Immune Responses by Staphylococcus aureus

(2013) F. Falugi et al.   mBio

Beta-carboline alkaloids derived from the ascidian Synoicum sp.

(2012) Tae Hyung Won et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nasal Carriage as a Source of agr-Defective Staphylococcus aureus Bacteremia

(2012) Davida S. Smyth et al.   JOURNAL OF INFECTIOUS DISEASES

Brominated Aromatic Furanones and Related Esters from the Ascidian Synoicum sp.

(2012) Tae Hyung Won et al.   JOURNAL OF NATURAL PRODUCTS

In vitro sortase a inhibitory and antimicrobial activity of flavonoids isolated from the roots of Sophora flavescens

(2011) Ikhoon Oh et al.   ARCHIVES OF PHARMACAL RESEARCH

The Sbi Protein Is a Multifunctional Immune Evasion Factor of Staphylococcus aureus

(2011) Emma Jane Smith et al.   INFECTION AND IMMUNITY

Sesterterpenes from the Tropical SpongeCoscinodermasp.

(2011) Jaemin Bae et al.   JOURNAL OF NATURAL PRODUCTS

Microtiter Dish Biofilm Formation Assay

(2011) George A. O'Toole   Jove-Journal of Visualized Experiments

Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase

(2010) Yeon-Ju Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discorhabdins from the Korean Marine SpongeSceptrellasp.

(2010) Ju-eun Jeon et al.   JOURNAL OF NATURAL PRODUCTS

Discovery and structure–activity relationship analysis of Staphylococcus aureus sortase A inhibitors

(2009) Nuttee Suree et al.   BIOORGANIC & MEDICINAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Infections caused by Gram-positive bacteria: a review of the global challenge

(2009) Neil Woodford et al.   JOURNAL OF INFECTION

S. aureus IgG-binding proteins SpA and Sbi: Host specificity and mechanisms of immune complex formation

(2007) Karen L. Atkins et al.   MOLECULAR IMMUNOLOGY