Review
Chemistry, Organic
Indrapal Singh Aidhen, Sriranjani Srikanth, Heera Lal
Summary: This review provides a brief overview of important dietary phenolics and their biological properties, serving as a guide for ongoing research in therapeutics.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Food Science & Technology
Oluwatoyin Oluwole, W. M. A. D. Binosha Fernando, Jane Lumanlan, Oluwaseun Ademuyiwa, Vijay Jayasena
Summary: Phytonutrients such as phenolics have significant roles in health and well-being, including antioxidant, chemopreventive, neuroprotective, cardioprotective, and immunomodulatory properties. Citrus fruits, herbs, and cereals are examples of flavonoid sources with biological functions. Regular consumption of plant sources rich in phenolic compounds can reduce oxidative stress, cancer, cardiovascular disease, and slow down memory loss.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Plant Sciences
Raimund Nagel, Almuth Hammerbacher, Grit Kunert, Michael A. Phillips, Jonathan Gershenzon, Axel Schmidt
Summary: This study found that mature Norway spruce trees can induce higher levels of terpenes and phenolics after being attacked by the spruce bark beetle and its associated fungus. However, the history of previous attacks did not influence the magnitude of these inductions.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Nutrition & Dietetics
Renata A. Carnauba, Flavia M. Sarti, Neuza M. A. Hassimotto, Franco M. Lajolo
Summary: This study estimated the polyphenol intake and major food sources in the Brazilian population using data from the National Dietary Survey. The results showed an increase in polyphenol intake over the past decade in Brazil, but still lower compared to other populations. The main food sources of polyphenols also showed some variations.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Renata A. Carnauba, Neuza M. A. Hassimotto, Franco M. Lajolo
Summary: This study estimated total and individual polyphenol intakes in a representative sample of the Brazilian population and identified major dietary contributors. Results showed that non-alcoholic beverages and fruits were the main suppliers of polyphenols, with coffee and orange juice being the main contributors. The study also highlighted the need for improved dietary quality in the Brazilian population for better health outcomes.
BRITISH JOURNAL OF NUTRITION
(2021)
Review
Chemistry, Medicinal
Qi-zhuang Lv, Jin-tao Long, Zi-feng Gong, Ke-yi Nong, Xiao-mei Liang, Ting Qin, Wei Huang, Lei Yang
Summary: This paper analyzes the antioxidant activities of polyphenols and their corresponding mechanisms, providing a systematic review of their antioxidant effects. The findings offer a significant theoretical basis for the development of products containing polyphenols.
NATURAL PRODUCT COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Patrik Runeberg, Dmitry Ryabukhin, Lucas Lagerquist, Jani Rahkila, Patrik Eklund
Summary: Thermal transformations of polyphenols from the lignan and stilbene families were investigated at different temperatures and solvents. The polyphenols showed different degrees of thermal stabilities and intramolecular transformations. Moreover, these polyphenols exhibited antioxidative properties at elevated temperatures, with stilbenes showing the most efficient protection against thermo-oxidative degradation of polyunsaturated fatty acids.
Review
Biochemistry & Molecular Biology
Mohamed M. Radwan, Suman Chandra, Shahbaz Gul, Mahmoud A. ElSohly
Summary: Cannabis sativa, one of the oldest medicinal plants in the world, contains a complex mixture of secondary metabolites, with cannabinoids and non-cannabinoid constituents being the main components. This review focuses on the chemistry of cannabinoids and major non-cannabinoid constituents, discussing their chemical structures, methods of isolation, and identification.
Review
Biochemistry & Molecular Biology
Yan Cheng, Fumin Xue, Shuai Yu, Shichao Du, Yu Yang
Summary: Subcritical water extraction (SBWE) utilizes high-temperature and high-pressure water to extract natural products, offering advantages in eco-friendliness, safe disposal, and tunable properties for selective extractions. Temperature optimization is key to efficiency, and different co-solvents can be used to enhance extraction of certain compounds.
Review
Immunology
Xueling Liu, Zhiguo Wang, Hua Qian, Wenhua Tao, Ying Zhang, Chunyan Hu, Weiwei Mao, Qi Guo
Summary: Rheumatoid arthritis is an autoimmune disease affecting joints, and natural medicines have shown potential therapeutic effects on RA through mechanisms such as anti-inflammation, anti-oxidation, and immune regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ting Xiao, Xingyan Cheng, Jiaoyan Huang, Zhenghong Guo, Ling Tao, Xiangchun Shen
Summary: In this study, one new compound and twenty-four known compounds were isolated from the fibrous roots of Alangium chinense. The compounds were identified and their inhibitory effects on COX-2 enzyme and cancer cells were evaluated. It was found that nine compounds showed good inhibition against COX-2 enzyme and four compounds exhibited cytotoxicity against cancer cells.
Review
Clinical Neurology
Chandra Kanta Bhusal, Daniel Ejim Uti, Dattatreya Mukherjee, Taha Alqahtani, Saud Alqahtani, Arghya Bhattacharya, Shopnil Akash
Summary: Parkinson's disease is a common neurodegenerative disorder characterized by degeneration of dopaminergic neurons. Natural phytocompounds have shown potential in managing PD, with their neuroprotective properties and ability to counteract neurodegenerative processes.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Anna Stasilowicz, Anna Tomala, Irma Podolak, Judyta Cielecka-Piontek
Summary: Cannabis sativa L. is a valuable source of chemical compounds with pharmacological activity, primarily acting on receptors of the endocannabinoid system and other receptors to exhibit therapeutic effects. The synergistic actions of phytochemicals in Cannabis extracts enhance their bioavailability and penetration through the blood-brain barrier, contributing to their clinical use in treating various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Shi Wu, Yaobin Pang, Yingjie He, Xiaotong Zhang, Li Peng, Jing Guo, Jinhao Zeng
Summary: Atopic dermatitis (AD) presents a significant challenge for patients, and natural products such as puerarin, ferulic acid, and ginsenosides have shown promise in protecting against AD by inhibiting inflammatory cell activity. Future research should focus on developing natural products that address the clinical characteristics of AD for potential treatment options.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Reyhaneh Farghadani, Rakesh Naidu
Summary: Breast cancer, in particular triple-negative breast cancer (TNBC), is a major cause of cancer-related deaths in women worldwide, and lacks targeted therapies. Polyphenols, found in plants, have shown potential as therapeutic strategies for TNBC. This review provides an overview of the anticancer effects of various polyphenols in TNBC, including inhibition of cell proliferation, induction of cell cycle arrest and apoptosis, and suppression of migration and invasion. The molecular mechanisms involve modulation of several signaling pathways, such as PI3K/Akt, MAPK, STATT, and NF-KB pathways. Clinical trials exploring the use of polyphenols, individually or in combination therapy, against breast cancer are also highlighted. This review enhances our understanding of the mechanism of action of different polyphenols and offers valuable insights into their potential as therapeutic strategies for TNBC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Rinshana Fathima Abdul Azeez, Susi Zara, Alessia Ricci, Sanal Dev, Ajeesh Vengamthodi, Fathima Sahla Kavully, Raihan Arikkattel Abdu, Kadeeja Thottungal Kalathil, Mohamed A. Abdelgawad, Bijo Mathew, Simone Carradori
Summary: A series of innovative anticancer compounds with new structures were designed and synthesized. Among them, compound 3 showed significant anti-proliferative effect by causing cell cycle arrest and increasing the release of reactive oxygen species.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Oncology
Aditi Redij, Simone Carradori, Andrea Petreni, Claudiu T. Supuran, Mrunmayee P. Toraskar
Summary: This study synthesized a series of coumarin derivatives incorporating pyrazole-1-carboxamide moiety and evaluated their inhibitory activity against carbonic anhydrase. The results showed that these compounds did not inhibit the widespread CA I and II, but showed sub-micromolar inhibitory activity against CA IX and XII with high selectivity.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Editorial Material
Public, Environmental & Occupational Health
Francesca Menniti-Ippolito, Eugenio Aiello, Elena Arzenton, Alessandro Assisi, Urska Blaznik, Jacqueline J. M. Castenmiller, Marta Crevani, Dominique de Clock, Silvia Di Giacomo, Silvia Emendi, Laura Augusta Gonella, Ilaria Ippoliti, Marie Lindquist, Lara Magro, Gabriela Mazzanti, Nadia Mores, Ugo Moretti, Paola Angela Moro, Budimka Novakovic, Emanuel Raschi, Inese Siksna, Maria Rosa Valetto, Annabella Vitalone, Gwenn Vo Van Regnault
Article
Biochemistry & Molecular Biology
Mehdi Valipour, Silvia Di Giacomo, Antonella Di Sotto, Hamid Irannejad
Summary: Previous studies have shown that natural-based chalcones can effectively inhibit coronavirus enzymes and modulate antiviral targets. This study investigated the inhibitory effects of 757 chalcone-based compounds on the enzymes and selected host-based targets. The results identified CHA-12 as the most potent multi-target inhibitor, and specific fragments in certain compounds were found to be effective in inhibiting the enzymes. The discovery of CHA-12 as a potential treatment for both respiratory symptoms and COVID-19 infection is significant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Irene Vitale, Mattia Spano, Valentina Puca, Simone Carradori, Stefania Cesa, Beatrice Marinacci, Francesca Sisto, Stefan Roos, Gianfranco Grompone, Rossella Grande
Summary: This study evaluated the antibiofilm activity of cell-free supernatant (CFS) and its sub-fractions (SurE 10 K and SurE) produced by Limosilactobacillus reuteri DSM 17938 against biofilm-producing bacterial species. The results showed that CFS exhibited promising antibiofilm activity against biofilms formed by clinically relevant microorganisms. NMR metabolomic analysis identified and quantified several compounds, mainly organic acids and amino acids, with lactate being the most abundant metabolite in all samples. The storage stability of these postbiotics was evaluated using the CIEL*a*b parameters.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cosimo Taiti, Giovanni Stefano, Ester Percaccio, Silvia Di Giacomo, Matteo Iannone, Andrea Marianelli, Antonella Di Sotto, Stefania Garzoli
Article
Food Science & Technology
Caterina Fraschetti, Enkelejda Goci, Alexandru Nicolescu, Francesco Cairone, Simone Carradori, Antonello Filippi, Vincenzo Palmieri, Andrei Mocan, Stefania Cesa
Summary: The pomegranate is a functional food with a high content of antioxidant and anti-inflammatory compounds. However, the fruits are prone to splitting during ripening, leading to significant losses in production. Therefore, it is important to find a way to utilize these valuable fruits and reduce the environmental impact.
Article
Chemistry, Medicinal
Ilaria D'Agostino, Susi Zara, Simone Carradori, Viviana De Luca, Clemente Capasso, Clemens H. M. Kocken, Anne-Marie Zeeman, Andrea Angeli, Fabrizio Carta, Claudiu T. Supuran
Summary: The hybrid compounds synthesized in this study, which combine the Artesunate core with a sulfonamide moiety, showed high inhibition potency against the protozoan PfCA, while exhibiting low cytotoxic effects on human cells, indicating a wide therapeutic window.
Article
Nutrition & Dietetics
Ester Percaccio, Marta De Angelis, Alessandra Acquaviva, Giovanna Nicotra, Claudio Ferrante, Gabriela Mazzanti, Silvia Di Giacomo, Lucia Nencioni, Antonella Di Sotto
Summary: Respiratory viral infections are challenging for susceptible and immunocompromised individuals. The study developed a mixture of Echinacea purpurea and Humulus lupulus extracts with antioxidant, cytoprotective, immunomodulating, and antiviral activities. Nrf2 activation may play a role in these properties. Further research can increase interest in this product.
Review
Biochemistry & Molecular Biology
Antonella Di Sotto, Mehdi Valipour, Aala Azari, Silvia Di Giacomo, Hamid Irannejad
Summary: Tylophorine and lycorine, two potential antiviral agents derived from plants, show broad-spectrum antiviral properties and anti-inflammatory effects. They may help combat respiratory viral infections, mitigate the oncogenic effects of viruses, and contribute to cancer research. However, further research is needed to address pharmacologic development issues.
Article
Chemistry, Medicinal
Simone Carradori, Alessandra Ammazzalorso, Sofia Niccolai, Damiano Tanini, Ilaria D'Agostino, Francesco Melfi, Antonella Capperucci, Rossella Grande, Francesca Sisto
Summary: The antimicrobial activity of Eugenol (EU) can be enhanced by incorporating chalcogens. This study designed and synthesized three different series of EU derivatives, and evaluated their antibacterial activity against Helicobacter pylori.
Article
Chemistry, Medicinal
Emanuela Berrino, Laura Micheli, Simone Carradori, Lorenzo di Cesare Mannelli, Paolo Guglielmi, Alessandro De Luca, Fabrizio Carta, Carla Ghelardini, Daniela Secci, Claudiu T. Supuran
Summary: Pain control is crucial in rheumatoid arthritis (RA) patients, but current treatments have limited effectiveness and risk of side effects. In this study, we proposed a novel approach combining carbonic anhydrase inhibitors (CAIs) with CO releasing molecules (CORMs). The resulting CAI-CORM hybrids showed significant anti-inflammatory effects and pain relief in RA rat models. Our findings demonstrate the potential of CAI-CORM hybrids as anti-nociceptive agents against arthritis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Plant Sciences
Silvia Di Giacomo, Ester Percaccio, Annabella Vitalone, Cinzia Ingallina, Luisa Mannina, Alberto Macone, Antonella Di Sotto
Summary: Hemp bioproducts, with their diverse bioactive compounds and potential health benefits, show great promise for nutraceutical and pharmaceutical applications. This study investigated the chemically characterized hydroalcoholic and organic extracts obtained from locally cultivated hemp varieties and found that they possess antimutagenic, radical scavenging, and cytotoxic properties. These findings suggest that bioactive compounds in hemp inflorescences could be harnessed for genoprotective and chemopreventive purposes.
