Quinolinic acid induces cell apoptosis in PC12 cells through HIF-1-dependent RTP801 activation

The endoplasmic reticulum stress and the HIF-1 signalling pathways are involved in the neuronal damage caused by chemical hypoxia

(2015) Beatriz López-Hernández et al.   BRITISH JOURNAL OF PHARMACOLOGY

RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death

(2015) Núria Martín-Flores et al.   MOLECULAR NEUROBIOLOGY

Biochemical, histopathological and behavioral alterations caused by intrastriatal administration of quinolic acid to young rats

(2014) Paula Pierozan et al.   FEBS Journal

Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons

(2014) Nady Braidy et al.   METABOLIC BRAIN DISEASE

O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway

(2014) Christina M. Ferrer et al.   MOLECULAR CELL

Rosiglitazone Synergizes the Neuroprotective Effects of Valproic Acid Against Quinolinic Acid-Induced Neurotoxicity in Rats: Targeting PPARγ and HDAC Pathways

(2014) Jitendriya Mishra et al.   NEUROTOXICITY RESEARCH

DDIT4/REDD1/RTP801 Is a Novel Negative Regulator of Schwann Cell Myelination

(2013) R. Noseda et al.   JOURNAL OF NEUROSCIENCE

Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke

(2013) Yi-Lin Cheng et al.   NEUROBIOLOGY OF DISEASE

Early modulation of the transcription factor Nrf2 in rodent striatal slices by quinolinic acid, a toxic metabolite of the kynurenine pathway

(2013) A.L. Colín-González et al.   NEUROSCIENCE

Quinolinic Acid: An Endogenous Neurotoxin with Multiple Targets

(2013) Rafael Lugo-Huitrón et al.   Oxidative Medicine and Cellular Longevity

Transcriptional regulation of specific protein 1 (SP1) by hypoxia-inducible factor 1 alpha (HIF-1α) leads to PRNP expression and neuroprotection from toxic prion peptide

(2012) Jae-Kyo Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism

(2012) M. Rahmani et al.   CANCER RESEARCH

Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy

(2012) T. W. H. Meijer et al.   CLINICAL CANCER RESEARCH

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chronic treadmill running protects hippocampal neurons from hypobaric hypoxia-induced apoptosis in rats

(2012) C. Lin et al.   NEUROSCIENCE

Heme oxygenase-1 (HO-1) upregulation delays morphological and oxidative damage induced in an excitotoxic/pro-oxidant model in the rat striatum

(2012) A.L. Colín-González et al.   NEUROSCIENCE

Excitotoxicity in the Pathogenesis of Autism

(2012) M. M. Essa et al.   NEUROTOXICITY RESEARCH

Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801

(2011) Xiao-mei Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Ischemic insult induced apoptotic changes in PC12 cells: Protection by trans resveratrol

(2011) Megha Agrawal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hyperthermia conditioned astrocyte-cultured medium protects neurons from ischemic injury by the up-regulation of HIF-1 alpha and the increased anti-apoptotic ability

(2011) Fang Du et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia

(2011) Guoxiang Yuan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia inducible factor-1α is involved in the neurodegeneration induced by isoflurane in the brain of neonatal rats

(2011) Hong Jiang et al.   JOURNAL OF NEUROCHEMISTRY

Calcium, ischemia and excitotoxicity

(2010) Kinga Szydlowska et al.   CELL CALCIUM

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

(2010) Toshinori Yoshida et al.   NATURE MEDICINE

Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

(2010) P. Horak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role and regulation of hypoxia-inducible factor-1α expression in brain development and neonatal hypoxic–ischemic brain injury

(2009) Xiyong Fan et al.   BRAIN RESEARCH REVIEWS

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Insulin Induces REDD1 Expression through Hypoxia-inducible Factor 1 Activation in Adipocytes

(2009) Claire Regazzetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia protects neuronal cells from human prion protein fragment-induced apoptosis

(2009) Jae-Suk Seo et al.   JOURNAL OF NEUROCHEMISTRY

Supplementation with a synthetic polyphenol limits oxidative stress and enhances neuronal cell viability in response to hypoxia–re-oxygenation injury

(2008) T.T. Hong Duong et al.   BRAIN RESEARCH

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT