β-glucan, a specific immuno-stimulant, produces rapid antidepressant effects by stimulating ERK1/2-dependent synthesis of BDNF in the hippocampus

A comprehensive review and meta-analysis of neurological side effects related to second-generation antidepressants in individuals with major depressive disorder

(2023) Qi Zhou et al.   BEHAVIOURAL BRAIN RESEARCH

β‐Glucan attenuates cognitive impairment of APP/PS1 mice via regulating intestinal flora and its metabolites

(2023) Qiwei Zhang et al.   CNS Neuroscience & Therapeutics

Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells

(2023) Yao Liu et al.   GLIA

Estimating the risk of irreversible post-SSRI sexual dysfunction (PSSD) due to serotonergic antidepressants

(2023) Joseph Ben-Sheetrit et al.   Annals of General Psychiatry

Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease

(2022) Joyce Keifer   JOURNAL OF NEUROSCIENCE RESEARCH

Adolescent microglia stimulation produces long-lasting protection against chronic stress-induced behavioral abnormalities in adult male mice

(2022) Yue Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

ERK1/2-dependent BDNF synthesis and signaling is required for the antidepressant effect of microglia stimulation

(2022) Xu Lu et al.   BRAIN BEHAVIOR AND IMMUNITY

Perspectives on the success rate of current antidepressant pharmacotherapy

(2022) Joseph F. Goldberg   EXPERT OPINION ON PHARMACOTHERAPY

Brain-Derived Neurotrophic Factor: A Novel Dynamically Regulated Therapeutic Modulator in Neurological Disorders

(2022) Veerta Sharma et al.   NEUROCHEMICAL RESEARCH

Systemic administration of β-glucan induces immune training in microglia

(2021) Yang Heng et al.   Journal of Neuroinflammation

β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis

(2021) Wei Pan et al.   Journal of Translational Medicine

BDNF signaling in depression and antidepressant action

(2021) Eero Castrén et al.   BIOLOGICAL PSYCHIATRY

PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression

(2021) Xin-Ya Qin et al.   ACTA NEUROPATHOLOGICA

Microglial depletion and abnormalities in gut microbiota composition and short-chain fatty acids in mice after repeated administration of colony stimulating factor 1 receptor inhibitor PLX5622

(2021) Yong Yang et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Inhibition of CSF1R, a receptor involved in microglia viability, alters behavioral and molecular changes induced by cocaine

(2021) Maria Carolina Machado da Silva et al.   Scientific Reports

Revisiting the Vital Drivers and Mechanisms of β-Glucan Masking in Human Fungal Pathogen, Candida albicans

(2021) Saif Hameed et al.   Pathogens

Stress-induced depressive-like behavior in male rats is associated with microglial activation and inflammation dysregulation in the hippocampus in adulthood

(2021) João Paulo Brás et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine

(2021) Wei Yao et al.   MOLECULAR PSYCHIATRY

Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders

(2021) Serena Camuso et al.   NEUROBIOLOGY OF DISEASE

Endocytic BDNF secretion regulated by Vamp3 in astrocytes

(2021) Jeongho Han et al.   Scientific Reports

The Role of BDNF on Neural Plasticity in Depression

(2020) Tao Yang et al.   Frontiers in Cellular Neuroscience

Astrocytic GABAB Receptors in Mouse Hippocampus Control Responses to Behavioral Challenges through Astrocytic BDNF

(2020) Ji-Hong Liu et al.   Neuroscience Bulletin

Minocycline prevents the depressive-like behavior through inhibiting the release of HMGB1 from microglia and neurons

(2020) Bo Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia modulate gliotransmission through the regulation of VAMP2 proteins in astrocytes

(2020) Fuyuko Takata‐Tsuji et al.   GLIA

Selective serotonin reuptake inhibitors in major depression disorder treatment: an umbrella review on systematic reviews

(2020) Mohsen Ghaffari Darab et al.   INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE

Antidepressive properties of macrophage-colony stimulating factor in a mouse model of depression induced by chronic unpredictable stress

(2020) Ting Ye et al.   NEUROPHARMACOLOGY

Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress

(2020) Zixuan Cai et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

To Kill a Microglia: A Case for CSF1R Inhibitors

(2020) Kim N. Green et al.   TRENDS IN IMMUNOLOGY

Yeast β-glucan alleviates cognitive deficit by regulating gut microbiota and metabolites in Aβ1–42-induced AD-like mice

(2020) Mengdai Xu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression- and anhedonia-like phenotypes in antibiotic-treated mice via the vagus nerve

(2020) Siming Wang et al.   Journal of Neuroinflammation

β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice

(2020) Hongli Shi et al.   Microbiome

Minocycline inhibits microglial activation and alleviates depressive-like behaviors in male adolescent mice subjected to maternal separation

(2019) Yue Han et al.   PSYCHONEUROENDOCRINOLOGY

The Brain-Derived Neurotrophic Factor: Missing Link Between Sleep Deprivation, Insomnia, and Depression

(2019) Maryam Rahmani et al.   NEUROCHEMICAL RESEARCH

Role of BDNF in the pathophysiology and treatment of depression: Activity‐dependent effects distinguish rapid‐acting antidepressants

(2019) Ronald S. Duman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis

(2019) Motoko Niida‐Kawaguchi et al.   NEUROPATHOLOGY

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

Cyclic β-glucans at the bacteria-host cells interphase: One sugar ring to rule them all

(2018) Leticia S. Guidolin et al.   CELLULAR MICROBIOLOGY

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

(2018) Marion J. F. Levy et al.   PSYCHOPHARMACOLOGY

Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex

(2018) Hyeonwi Son et al.   NEUROPHARMACOLOGY

Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses

(2017) Lijuan Tong et al.   NEUROCHEMICAL RESEARCH

Efficacy and Safety of Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake Inhibitors, and Placebo for Common Psychiatric Disorders Among Children and Adolescents

(2017) Cosima Locher et al.   JAMA Psychiatry

β-glucan attenuated scopolamine induced cognitive impairment via hippocampal acetylcholinesterase inhibition in rats

(2016) Ali Haider et al.   BRAIN RESEARCH

Neuroinflammation triggered by β-glucan/dectin-1 signaling enables CNS axon regeneration

(2015) Katherine T. Baldwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Glucan Activates Microglia without Inducing Cytokine Production in Dectin-1-Dependent Manner

(2014) V. B. Shah et al.   JOURNAL OF IMMUNOLOGY

Endotoxin-induced experimental systemic inflammation in humans: A model to disentangle immune-to-brain communication

(2013) Manfred Schedlowski et al.   BRAIN BEHAVIOR AND IMMUNITY

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4

(2012) Z. Chen et al.   JOURNAL OF NEUROSCIENCE

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline

(2011) Shiho Arakawa et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans

(2011) J. L. Warner-Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnetic Resonance Spectroscopy Studies of Glutamate-Related Abnormalities in Mood Disorders

(2010) Cagri Yüksel et al.   BIOLOGICAL PSYCHIATRY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Minimal penetration of lipopolysaccharide across the murine blood–brain barrier

(2009) William A. Banks et al.   BRAIN BEHAVIOR AND IMMUNITY