Pharmacokinetics, Mass Balance and Metabolism of [14C]HSK21542, a Novel Kappa Opioid Receptor Agonist, in Humans

Pharmacokinetics, Metabolism, and Excretion of Intravenous [14C]Difelikefalin in Healthy Subjects and Subjects on Hemodialysis

(2023) Jeffrey G. Stark et al.   CLINICAL PHARMACOKINETICS

Absorption, metabolism, and excretion of [14C]YY-20394, a highly selective PI3K-Delta inhibitor in humans

(2022) Jinghua Yu et al.   XENOBIOTICA

Pharmacokinetics, mass balance, and metabolism of [14C]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension

(2022) Yi-fei He et al.   ACTA PHARMACOLOGICA SINICA

Role of kappa‐opioid and mu‐opioid receptors in pruritus: Peripheral and central itch circuits

(2022) Brian S. Kim et al.   EXPERIMENTAL DERMATOLOGY

Mass balance, pharmacokinetics and pharmacodynamics of intravenous HSK3486, a novel anaesthetic, administered to healthy subjects

(2020) Yicong Bian et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetics, mass balance, and metabolism of [14C]vicagrel, a novel irreversible P2Y12 inhibitor in humans

(2020) Yuan-dong Zheng et al.   ACTA PHARMACOLOGICA SINICA

Human mass balance, pharmacokinetics and metabolism of rovatirelin and identification of its metabolic enzymes in vitro

(2019) Kaoru Kobayshi et al.   XENOBIOTICA

Evaluation of absorption, distribution, metabolism, and excretion of [14C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors

(2019) Mingxiang Liao et al.   INVESTIGATIONAL NEW DRUGS

Pharmacokinetics, Biotransformation, and Excretion of [14C]Etelcalcetide (AMG 416) Following a Single Microtracer Intravenous Dose in Patients with Chronic Kidney Disease on Hemodialysis

(2016) Raju Subramanian et al.   CLINICAL PHARMACOKINETICS

Regulatory aspects of human radiolabeled mass balance studies in oncology: concise review

(2016) C. M. Nijenhuis et al.   DRUG METABOLISM REVIEWS

Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?

(2012) Natalia Penner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mu, Delta, and Kappa opioid receptor agonists induce peripheral antinociception by activation of endogenous noradrenergic system

(2012) Thiago R.L. Romero et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effects of peripheral κ opioid receptor activation on inflammatory mechanical hyperalgesia in male and female rats

(2012) Q-Schick Auh et al.   NEUROSCIENCE LETTERS

Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance

(2010) Hongbin Yu et al.   Expert Opinion on Drug Metabolism & Toxicology

Human radiolabeled mass balance studies: objectives, utilities and limitations

(2009) Natalia Penner et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

kappa-Opioid receptor signaling and brain reward function

(2009) Adrie W. Bruijnzeel   BRAIN RESEARCH REVIEWS