4.7 Article

In cellulo protein labelling with Ru-conjugate for luminescence imaging and bioorthogonal photocatalysis

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 93, Pages 16664-16666

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc05405b

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Funding

  1. Swiss National Science Foundation
  2. NCCR chemical biology

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Labelling of proteins with a luminescent ruthenium complex enables the direct visualization and photocatalytic reduction of aryl azide in live cells. The confinement of catalysis to the labeled proteins was visualized using an azide-based immolative linker releasing a precipitating dye.

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