Article
Endocrinology & Metabolism
Sofia Ish-Shalom, Yoseph Caraco, Nariman Saba Khazen, Michal Gershinsky, Auryan Szalat, Phillip Schwartz, Ehud Arbit, Hillel Galitzer, Jonathan C. Y. Tang, Gregory Burshtein, Ariel Rothner, Arthur Raskin, Miriam Blum, William D. Fraser
Summary: Oral hPTH(1-34) treatment as an adjunct to standard therapy in adult patients with hypoparathyroidism was found to be safe and effective, allowing for a reduction in exogenous calcium supplementation while maintaining normocalcemia.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Guido Zavatta, Peter J. Tebben, Cynthia H. McCollough, Lifeng Yu, Thomas Vrieze, Bart L. Clarke
Summary: Basal ganglia calcification is more common in chronic hypoparathyroidism patients, especially in nonsurgical patients with lower serum calcium and calcium/phosphate ratio.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Liang Yao, Xu Hui, Meixuan Li, Jing Li, Muhammad Muneeb Ahmed, Clement Lin, Maryam Kandi, Ashwini Sreekanta, Nima Makhdami, Divya Tamilselvan, Dalal S. Ali, Karel Dandurand, Kehu Yang, John P. Bilezikian, Maria Luisa Brandi, Bart L. Clarke, Michael Mannstadt, Lars Rejnmark, Aliya A. Khan, Gordon Guyatt
Summary: This study aimed to identify symptoms and complications associated with chronic hypoparathyroidism and evaluate the predictive value of early postoperative measurements of PTH and calcium. The results revealed nine common complications and symptoms likely associated with chronic hypoparathyroidism. PTH values above 10 pg/mL 12-24 hours after surgery were strong predictors of no chronic hypoparathyroidism development, while patients with PTH values below the threshold required careful monitoring.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Guido Zavatta, Paola Altieri, Giulia Vandi, Valentina Vicennati, Uberto Pagotto, Fabio Vescini
Summary: New insights into phosphate metabolism present challenges for endocrinologists to rethink pathophysiology. Studying rare mineral metabolism diseases can provide valuable new information about phosphate and other minerals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Aliya A. Khan, Gordon Guyatt, Dalal S. Ali, John P. Bilezikian, Michael T. Collins, Karel Dandurand, Michael Mannstadt, Deborah Murphy, Iman M'Hiri, Mishaela R. Rubin, Robert Sanders, Muhammad Shrayyef, Heide Siggelkow, Gaia Tabacco, Yu-Kwang Donovan Tay, Stan Van Uum, Tamara Vokes, Karen K. Winer, Liang Yao, Lars Rejnmark
Summary: Hypoparathyroidism is a rare disorder characterized by low calcium levels due to decreased parathyroid hormone. Neck surgery is the most common cause. Conventional therapy includes calcium and vitamin D analogues, but it has limitations. Parathyroid hormone replacement therapy may be beneficial for unsatisfactory cases.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Lukas Ochsner Ridder, Torben Harslof, Tanja Sikjaer, Line Underbjerg, Lars Rejnmark
Summary: Hypercalciuria, impaired kidney function, and renal calcifications are common in hypoparathyroidism. Urinary calcium levels are influenced by various physiological factors, but in this study, high urinary calcium levels did not significantly explain renal impairment or kidney calcifications.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Pediatrics
Amish Chinoy, Mohammed Zulf Mughal, Raja Padidela
Summary: The study identified different emphasis placed by neonatologists and endocrinologists on various screening, diagnostic, and monitoring investigations for MBDP in the UK. Neonatologists focused more on serum phosphate and alkaline phosphatase levels, while endocrinologists placed greater importance on plasma parathyroid hormone levels.
Article
Surgery
Yuxuan Qiu, Yuan Fei, Zhichao Xing, Jingqiang Zhu, Yan Luo, Anping Su
Summary: Autotransplantation of parathyroid glands (PGs) is an effective strategy for preserving parathyroid function in the mid and long term. Although transient hypoparathyroidism is positively correlated with the number of autotransplanted PGs, there is no remarkable correlation with permanent hypoparathyroidism.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Endocrinology & Metabolism
Georgios Kontogeorgos, Zoi Mamasoula, Emily Krantz, Penelope Trimpou, Kerstin Landin-Wilhelmsen, Christine M. Laine
Summary: The study showed that patients with HypoPT had significantly lower physical and mental health-related quality of life compared to controls, with 23% of patients experiencing low HRQoL and low calcium levels simultaneously. Despite being on more medications and having poorer renal function, HypoPT patients did not have higher mortality rates than controls.
ENDOCRINE CONNECTIONS
(2022)
Article
Engineering, Multidisciplinary
Yi Wang, Zhuowen Hao, Yufeng Zhang, Yingkun Hu, Tianhong Chen, Feifei Yan, Minhao Wu, Chong Zhang, Renxin Chen, Beihai Li, Xinxin Wu, Hanke Li, Qixin Zheng, Xiaodong Guo, Guohui Liu, Zhenwei Zou, Jingfeng Li, Lin Cai
Summary: Bone regeneration requires the interaction of multiple factors, including osteogenesis, osteolysis, angiogenesis, and an appropriate immune microenvironment. Recombinant human parathyroid hormone (PTH1-34) has been proven effective for clinical treatment of osteoporosis. However, its use in local bone repair is limited due to net bone resorption. This study proposes a strategy using multifunctional calcium phosphate (CaP) ceramics to modulate the effects of M1 macrophages and promote bone regeneration. The functionalization of the CaP ceramic scaffold with parathyroid hormone related peptide-1 (PTHrP-1) improves the osteogenic microenvironment, retains osteogenic and angiogenic properties, and achieves slow release of PTHrP-1. The results show that PTHrP-1-TBC is more suitable for bone regeneration than the unmodified peptide or the TBC scaffold alone.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Endocrinology & Metabolism
Liang Yao, Gordon Guyatt, Zhikang Ye, John P. Bilezikian, Maria Luisa Brandi, Bart L. Clarke, Michael Mannstadt, Aliya A. Khan
Summary: This article describes the methodology and process of issuing GRADEd and non-GRADEd recommendations for patients with hypoparathyroidism or hyperparathyroidism.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Liang Yao, Jing Li, Meixuan Li, Clement Lin, Xu Hui, Divyalakshmi Tamilselvan, Maryam Kandi, Ashwini Sreekanta, Nima Makhdami, Dalal S. Ali, Karel Dandurand, Kehu Yang, John P. Bilezikian, Maria Luisa Brandi, Bart L. Clarke, Michael Mannstadt, Lars Rejnmark, Aliya A. Khan, Gordon Guyatt
Summary: The efficacy and safety of PTH therapy for managing long-term hypoparathyroidism is being evaluated, and this systematic review and meta-analysis found that PTH therapy may improve physical health-related quality of life and reduce the dose of active vitamin D and calcium in patients with chronic hypoparathyroidism, but it may increase the risk of hypercalcemia.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Urology & Nephrology
Charles Ginsberg, Lindsay M. Miller, Norma Ofsthun, Lorien S. Dalrymple, Joachim H. Ix
Summary: The study found that PTH and phosphate concentrations before dialysis session varied with the time of day in patients receiving maintenance hemodialysis, highlighting the potential impact on treatment decisions.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Patrick Hanna, Ashok Khatri, Shawn Choi, Severine Brabant, Matti L. Gild, Marie L. Piketty, Bruno Francou, Dominique Prie, John T. Potts Jr, Roderick J. Clifton-Bligh, Agnes Linglart, Thomas J. Gardella, Harald Juppner
Summary: This study found that a homozygous mutation in PTH leads to abnormal processing of its precursor sequence, resulting in the inability to activate cells. Commercial assays were unable to accurately detect the presence of this variant in patient plasma.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Physiology
R. Todd Alexander, Henrik Dimke
Summary: Central to the maintenance of calcium homeostasis is the regulated reabsorption of calcium along the nephron. Parathyroid hormone (PTH) acts through the PTH 1 receptor along the nephron to increase urinary phosphate excretion and decrease urinary calcium excretion. PTH inhibits phosphate reabsorption in the proximal tubule, decreases calcium reabsorption in the proximal tubule and increases calcium permeability in the thick ascending limb, and increases transcellular calcium reabsorption in the distal convolution.