Article
Endocrinology & Metabolism
Fangfang Di, Danfeng Gao, Lihua Yao, Runjie Zhang, Jin Qiu, Liwen Song
Summary: Polycystic ovary syndrome (PCOS) often coexists with a metabolic disorder, and dysfunction of adipose tissue, especially abdominal adipose tissue, can worsen reproductive and metabolic problems in PCOS patients. The study used LC-MS/MS to analyze adipose samples from PCOS patients, and identified PCOS biomarkers engaged in inflammatory diseases and mitochondrial beta-oxidation. In vitro experiments showed that isoleucine could ameliorate the effects of hyperandrogenism on granulosa cells and related metabolic disorders. GC-MS/MS analysis revealed significantly decreased levels of isoleucine in PCOS patients. The findings suggest that metabolome alterations could be a novel therapeutic target for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiaohua Li, Laifang Zhu, Yan Luo
Summary: This study suggests that the long non-coding RNA HLA-F antisense RNA 1 (HLA-F-AS1) interacts with premature MicroRNA-613 (miR-613) to promote granulosa cell proliferation and inhibit cell apoptosis in polycystic ovary syndrome (PCOS).
Article
Medicine, Research & Experimental
Tianjin Yang, Lie Wang, Yun Zhang, Jindan Zheng, Lili Liu
Summary: MiR-451a regulates the biological functions of ovarian granulosa cells in polycystic ovary syndrome by targeting ATF2, affecting cell proliferation and apoptosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, General & Internal
Li Li, Jianxun Wei, Jiangrong Hei, Yongbian Ren, Hongmei Li
Summary: The study found that lncRNA H19 is significantly upregulated in the ovaries and granulosa cells of PCOS patients, and its inhibition can lead to inhibited granulosa cell proliferation and apoptosis induction. Additionally, bioinformatic analysis revealed the presence of a STAT3 binding site in the promoter of lncRNA H19.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Xiaohui Lu, Haijie Gao, Bo Zhu, Guilan Lin
Summary: PCOS is a complex endocrine disorder affecting many women, and circRNAs such as circ_RANBP9 play a role in its development. In this study, increased levels of circ_RANBP9 were found in PCOS patients and ovarian granulosa cells, and its silencing inhibited cell proliferation and promoted apoptosis by mediating the miR-136-5p/XIAP pathway. These findings provide new insights into potential therapeutic targets for PCOS.
Article
Endocrinology & Metabolism
Xiao-lin Jiang, He Tai, Xuan-si Xiao, Shi-yu Zhang, Shi-chao Cui, Shu-bo Qi, Dan-dan Hu, Li-na Zhang, Jin-song Kuang, Xian-sheng Meng, Shun-min Li
Summary: This study found that CFDT can alleviate pathological damage and apoptosis in PCOS rat model. In addition, CFDT can improve ovarian function, reduce inflammatory response, inhibit apoptosis of granular cells, and inhibit the operation of ASK1/JNK pathway in PCOS rats.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Jie Deng, Chanyu Li, Jianbo Luo, Jiaqiong Xie, Cong Peng, Xiaoyang Deng
Summary: This study revealed the important role of miR-125b in the pathogenesis of PCOS, as it controls the proliferation rate of granulosa cells in polycystic ovaries. The inhibition of miR-125b decreased cell viability by regulating cyclin B1 expression, suggesting that miR-125b could be a potential therapeutic target for PCOS patients.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Obstetrics & Gynecology
Alexandra Dietz de Loos, Martin Hund, Katharina Buck, Cindy Meun, Johanna Sillman, Joop S. E. Laven
Summary: The study aimed to determine a cutoff for the Elecsys AMH Plus immunoassay to aid in PCOM diagnosis. The results showed that a cutoff of 3.2 ng/mL (23 pmol/L) demonstrated high sensitivity and specificity for PCOM diagnosis, with consistent performance across different ages and PCOS phenotypes.
FERTILITY AND STERILITY
(2021)
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Christos Damaskos, Nikolaos Garmpis, Kleio Vrettou, Anna Garmpi, Efstathios A. Antoniou, Athanasios Chionis, Konstantinos Nikolettos, Konstantinos Kontzoglou, Dimitrios Dimitroulis
Summary: Polycystic ovary syndrome (PCOS) is strongly associated with ovarian torsion, which is a significant risk in patients with enlarged ovaries. The most common symptom is acute lower abdominal pain, and diagnosis usually involves ultrasound and CT or MRI scans. Emergency laparoscopy with ovarian or adnexal detorsion is the standard treatment, while ovariopexy or ovariectomy/adnexectomy may be considered for recurrent torsions.
Article
Biochemistry & Molecular Biology
Dongqin Bao, Mingan Li, Dongxia Zhou, Chaohui Zhuang, Zhijuan Ge, Qian Wei, Limin Zhang
Summary: This study revealed that miR-130b-3p overexpression or SMAD4 silencing can promote KGN cell proliferation, induce S phase arrest, inhibit apoptosis and caspase-3 activity; conversely, miR-130b-3p inhibitors reduce proliferation, inhibit apoptosis and reverse the effect of si-SMAD4.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Brandao Bruna Brasil, Sakaguchi Masaji, Thiago Martins Batista, Hu Jiang, Nie Song, A. Schepmoes Athena, BonDurant Lucas, Moreau Francois, Qian Wei-Jun, Kulkarni N. Rohit, Kahn C. Ronald
Summary: Insulin and IGF-1 receptors are crucial for the survival of mature adipocytes. Deletion of these receptors results in loss of adipose tissue and the development of metabolic syndrome. The study suggests that APOC3 and other unidentified circulating growth factors are involved in preadipocyte proliferation and regulation of adipose mass.
MOLECULAR METABOLISM
(2022)
Article
Medicine, Research & Experimental
Gokul Sudhakaran, Sarvesh Ramesh Babu, Hridai Mahendra, Jesu Arockiaraj
Summary: Polycystic ovarian syndrome (PCOS) is caused by hormonal imbalance and hyperandrogenism. Animal models are commonly used to study PCOS due to their similarity to human PCOS, but the pathogenesis of PCOS is still unclear. Novel drugs from different sources are being screened as therapeutic strategies for PCOS and its symptoms. Simplified cell line in-vitro models can be used to preliminarily screen the bioactivity of various drugs. This review focuses on different cell line models for PCOS and its complications, allowing for preliminary drug screening before moving to higher animal models.
Article
Medicine, Research & Experimental
Yasmine F. Ibrahim, Mohammed Alorabi, Walaa Yehia Abdelzaher, Nisreen D. M. Toni, Khaled Thabet, AbdelRahman Hegazy, Haitham Ahmed Bahaa, Gaber El-Saber Batiha, Nermeen N. Welson, Mohamed A. Morsy, Katharigatta N. Venugopala, Asmaa Mohamed Abdel-Aziz
Summary: The current study found that diacerein (DIA) can ameliorate letrozole-induced PCOS through its antioxidant and anti-inflammatory properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Junzi Wei, Ping Cheng, Mei Kong, Ling Zhang, Shuang Liu, Bingxue Ning, Xinlin Huang
Summary: In this study, the downregulation of miR-23a-3p was found to be associated with the development of polycystic ovarian syndrome (PCOS). The results revealed that miR-23a-3p negatively targets HMGA2 in granular cells (GCs), leading to the inhibition of the Wnt/beta-catenin pathway and subsequent decrease in GC viability and increase in apoptosis.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Qingjie Peng, Xiaojiang Chen, Xiaoxia Liang, Jiahui Ouyang, Qiangqiang Wang, Shuai Ren, Haibo Xie, Chunhong Wang, Yaqun Sun, Xin Wu, Hetao Liu, Changchun Hei, Miao Sun, Qing Chang, Xinrui Liu, Guangyong Li, Rui He
Summary: The study investigated the effect of metformin on PCOS using a PCOS mouse model and explored the mechanism of metformin in regulating PCOS mice through the ferroptosis pathway. The results showed that metformin not only improved body weight and metabolic disorders but also improved ovarian dysfunction in PCOS mice.
FRONTIERS IN ENDOCRINOLOGY
(2023)